Contingently Issuable Common Stock (Details) - USD ($) $ / shares in Units, $ in Thousands, shares in Millions			3 Months Ended		9 Months Ended
	Jun. 17, 2014	Dec. 10, 2010	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Fair Value of Contingently Issuable Common Stock
Beginning balance					$ 14,700
Fair Value Adjustment of Contingent Payment for the nine months ended September 30, 2016			$ 0	$ 0	100	$ 200
Ending balance			$ 14,800		14,800
Nelix Milestones
Business Acquisition [Line Items]
Number of shares contingently issuable (in shares)		10.2
Estimated fair value of contingent payment		$ 28,200
OUS Milestone
Business Acquisition [Line Items]
Purchase price common shares (in shares)	2.7
OUS Milestone | Common Stock
Business Acquisition [Line Items]
Contingent consideration, liability, value, low					10,000
Contingent consideration, liability, value, high					$ 24,000
Contingent consideration, liability, shares, high (in shares)					6.9
Contingent consideration, liability, shares, low (in shares)					1.3
OUS Milestone | Common Stock | Minimum
Business Acquisition [Line Items]
Share price (in dollars per share)			$ 3.50		$ 3.50
OUS Milestone | Common Stock | Maximum
Business Acquisition [Line Items]
Share price (in dollars per share)			$ 7.50		$ 7.50
PMA Milestone
Business Acquisition [Line Items]
Common shares value			$ 15,000		$ 15,000
Number of shares contingently issuable (in shares)					1.2
Closing stock price (in dollars per share)			$ 12.80		$ 12.80
Contingent consideration, at fair value hypothetical value			$ 15,700		$ 15,700
PMA Milestone | Minimum
Business Acquisition [Line Items]
Share price (in dollars per share)			$ 4.5		$ 4.5
Nellix
Business Acquisition [Line Items]
Purchase price common shares (in shares)		3.2
Common shares value		$ 19,400