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Stock-Based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense $ 3,886 $ 2,408 $ 6,768 $ 4,619
Cost of goods sold        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense 259 226 532 474
Research and development        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense 434 258 797 486
Clinical and regulatory affairs        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense 593 243 493 428
Marketing and sales        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense 1,261 839 2,391 1,587
General and administrative        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense 1,339 842 2,555 1,644
Total operating expenses        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated stock-based compensation expense $ 3,627 $ 2,182 $ 6,236 $ 4,145