Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Cash flows from operating activities:
Net loss	$ (50,424)	$ (32,418)	$ (16,068)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Deferred income taxes	(9,635)	(247)	101
Bad debt expense	107	0	204
Depreciation and amortization	5,886	3,283	2,351
Stock-based compensation	9,255	7,867	7,922
Change in fair value of contingent consideration related to acquisition	100	(7,928)	8,500
Common stock issued for business development	0	258	752
Accretion of interest on convertible note	4,283	3,306	175
Accretion on marketable securities	59	260	0
Loss on disposal of assets	58	180	0
Amortization of deferred financing costs	559	413	21
Non-cash foreign exchange (gain) loss	(504)	5,740	(1,731)
Changes in operating assets and liabilities:
Accounts receivable and other receivables	(3,193)	(2,009)	(2,440)
Inventories	3,528	(12,489)	(1,046)
Prepaid expenses and other current assets	167	(632)	(769)
Accounts payable	8,342	2,727	(196)
Accrued payroll	(75)	1,988	3,546
Accrued expenses and other current liabilities	395	3,367	172
Net cash (used in) provided by operating activities	(31,092)	(26,334)	1,494
Cash flows from investing activities:
Purchases of marketable securities	(82,646)	(121,015)	(31,313)
Maturity on marketable securities	89,690	92,197	0
Purchases of property and equipment	(4,191)	(13,461)	(2,862)
Intuitrak Shonin	0	(1,000)	0
Net cash (used in) provided by investing activities	2,853	(43,279)	(34,175)
Cash flows from financing activities:
Deferred financing costs	(3,617)	0	(3,657)
Proceeds from sale of common stock under employee stock purchase plan	2,962	2,613	2,444
Proceeds from exercise of stock options	2,871	1,776	4,875
Proceeds from convertible debt	125,000	0	86,250
Funding of restricted cash account	0	0	5,395
Release of restricted cash account	0	0	(5,395)
Minimum tax withholding paid on behalf of employees for restricted stock units	(481)	(2,328)	0
Purchase of capped call	0	0	(7,418)
Net cash provided by financing activities	126,735	2,061	82,494
Effect of exchange rate changes on cash and cash equivalents	(741)	(802)	221
Net increase (decrease) in cash and cash equivalents	97,755	(68,354)	50,034
Cash and cash equivalents, beginning of year	26,798	95,152	45,118
Cash and cash equivalents, end of year	124,553	26,798	95,152
Supplemental disclosure of cash flow information:
Cash paid for interest	1,957	2,018	16
Cash paid for income taxes	124	258	171
Non-cash investing and financing activities:
Landlord funded leasehold improvements	46	5,265	1,485
Fair Value of OUS Milestone Shares (note 9)	0	38,372	0
Acquisition of property and equipment included in accounts payable	$ 155	$ 2,612	$ 0