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Contingently Issuable Common Stock (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
12 Months Ended
Jun. 17, 2014
Dec. 10, 2010
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Jun. 16, 2014
Fair Value of Contingently Issuable Common Stock [Roll Forward]            
Fair value of contingent payment     $ 14,600      
Change in fair value of contingent consideration related to acquisition     100 $ (7,928) $ 8,500  
Fair value of contingent payment     $ 14,700 $ 14,600    
Nelix Milestones            
Business Acquisition [Line Items]            
Purchase price of common shares     1.5      
Contingently issuable shares   10.2        
Fair value of contingent payment   $ 28,200        
OUS Milestone            
Business Acquisition [Line Items]            
Purchase price of common shares 2.7          
Contingent consideration liability, lower estimate   10,000        
Contingent consideration liability, upper estimate   $ 24,000        
OUS Milestone | Common Stock            
Business Acquisition [Line Items]            
Business Combination, Contingent Consideration Arrangements, Change in Range of Outcomes, Contingent Consideration, Liability, Shares, Low   1.3        
Business Combination, Contingent Consideration Arrangements, Change in Range of Outcomes, Contingent Consideration, Liability, Shares, High   6.9        
OUS Milestone | Common Stock | Maximum            
Business Acquisition [Line Items]            
Share price           $ 7.50
OUS Milestone | Common Stock | Minimum            
Business Acquisition [Line Items]            
Share price           $ 3.50
PMA Milestone            
Business Acquisition [Line Items]            
Value of common shares   $ 15,000        
Closing stock price     $ 9.90      
Fair Value Hypothetical Value     $ 15,100      
PMA Milestone | Maximum            
Business Acquisition [Line Items]            
Closing stock price   $ 4.50        
Nellix            
Business Acquisition [Line Items]            
Purchase price of common shares   3.2        
Value of common shares   $ 19,400