Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Cash flows from operating activities:
Net loss	$ (32,418)us-gaap_NetIncomeLoss	$ (16,068)us-gaap_NetIncomeLoss	$ (35,774)us-gaap_NetIncomeLoss
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Bad debt expense	0us-gaap_ProvisionForDoubtfulAccounts	204us-gaap_ProvisionForDoubtfulAccounts	325us-gaap_ProvisionForDoubtfulAccounts
Depreciation and amortization	3,283	2,351	2,183
Stock-based compensation	7,867us-gaap_ShareBasedCompensation	7,922us-gaap_ShareBasedCompensation	6,471us-gaap_ShareBasedCompensation
Change in fair value of contingent consideration related to acquisition	(7,928)	8,500	13,700
Common stock issued for business development	258us-gaap_BusinessDevelopment	752us-gaap_BusinessDevelopment	0us-gaap_BusinessDevelopment
Accretion of interest on convertible note	3,306us-gaap_AccretionExpense	175us-gaap_AccretionExpense	0us-gaap_AccretionExpense
Loss (Gain) on disposal of assets	180	0	0
Amortization of deferred financing costs	413	21	0
Non-cash foreign exchange gain (loss)	5,740	(1,731)	0
Changes in operating assets and liabilities:
Accounts receivable and other receivables	(2,009)	(2,440)	(8,319)
Accretion on marketable securities	260	0	0
Inventories	(12,489)us-gaap_IncreaseDecreaseInInventories	(1,046)us-gaap_IncreaseDecreaseInInventories	12us-gaap_IncreaseDecreaseInInventories
Prepaid expenses and other current assets	(632)	(769)	(408)
Accounts payable	2,727	(196)	199
Accrued payroll	1,988	3,546	1,255
Accrued expenses and other current liabilities	3,120	273	1,827
Net cash (used in) provided by operating activities	(26,334)	1,494	(18,529)
Cash flows from investing activities:
Purchases of marketable securities	(121,015)	(31,313)	0
Maturity on marketable securities	92,197	0	0
Purchases of property and equipment	(13,461)	(2,862)	(2,238)
Purchases of patent license	0us-gaap_LicenseCosts	0us-gaap_LicenseCosts	(100)us-gaap_LicenseCosts
Intuitrak Shonin	(1,000)	0	0
Business acquisition	0	0	(1,156)
Net cash used in investing activities	(43,279)	(34,175)	(3,494)
Cash flows from financing activities:
Deferred financing costs	0us-gaap_AmortizationOfFinancingCosts	(3,657)us-gaap_AmortizationOfFinancingCosts	0us-gaap_AmortizationOfFinancingCosts
Proceeds from sale of common stock under secondary offering, net of expenses	0	0	40,069
Proceeds from sale of common stock under employee stock purchase plan	2,613	2,444	2,369
Proceeds from exercise of stock options	1,776	4,875	4,992
Funding of restricted cash account	0us-gaap_IncreaseInRestrictedCash	5,395us-gaap_IncreaseInRestrictedCash	0us-gaap_IncreaseInRestrictedCash
Release of restricted cash account	0us-gaap_DecreaseInRestrictedCash	(5,395)us-gaap_DecreaseInRestrictedCash	0us-gaap_DecreaseInRestrictedCash
Proceeds from convertible debt	0us-gaap_ProceedsFromConvertibleDebt	86,250us-gaap_ProceedsFromConvertibleDebt	0us-gaap_ProceedsFromConvertibleDebt
Purchase of treasury shares	(2,328)	0	0
Purchase of capped call	0	(7,418)	0
Net cash provided by financing activities	2,061	82,494	47,430
Effect of exchange rate changes on cash and cash equivalents	(802)	221	(324)
Net increase (decrease) in cash and cash equivalents	(68,354)	50,034	25,083
Cash and cash equivalents, beginning of period	95,152	45,118	20,035
Cash and cash equivalents, end of period	26,798	95,152	45,118
Supplemental disclosure of cash flow information:
Cash paid for interest	2,018us-gaap_InterestPaid	16us-gaap_InterestPaid	10us-gaap_InterestPaid
Cash paid for income taxes	258us-gaap_IncomeTaxesPaid	171us-gaap_IncomeTaxesPaid	16us-gaap_IncomeTaxesPaid
Supplemental disclosure of cash flow information:
Landlord funded leasehold improvements	5,265us-gaap_OtherRealEstateImprovements	1,485us-gaap_OtherRealEstateImprovements	0us-gaap_OtherRealEstateImprovements
Fair Value of OUS Milestone Shares (note 9)	38,372	0	0
Acquisition of property and equipment included in accounts payable	$ 2,612	$ 0	$ 0

The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method.

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Improvements to other real estate not separately disclosed, including, but not limited to, real estate investments, real estate loans that qualify as investments in real estate, and premises that are no longer used in operations may also be included in real estate owned. This excludes real estate assets taken in settlement of troubled loans through surrender or foreclosure.

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Cash outflow for purchase of trading, available-for-sale securities and held-to-maturity securities.

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Amount of cash inflow (outflow) from other long-term debt.

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Equity impact of the cost of common and preferred stock that were repurchased during the period. Recorded using the cost method.

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