The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 4,524 186,789 SH   SOLE   186,789 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 1,058 459,300 SH Put SOLE   459,300 0 0
ACCELERATE DIAGNOSTICS INC COM 00430H102 3,934 2,731,856 SH   SOLE   2,731,856 0 0
AGENUS INC COM NEW 00847G705 21,417 8,706,132 SH   SOLE   8,706,132 0 0
ANTARES PHARMA INC COM 036642106 7,052 1,720,000 SH   SOLE   1,720,000 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 149 50,000 SH   SOLE   50,000 0 0
ARK ETF TR INNOVATION ETF 00214Q104 16,573 250,000 SH   SOLE   250,000 0 0
ASPIRA WOMENS HEALTH INC COM 04537Y109 2,202 2,116,839 SH   SOLE   2,116,839 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 27,979 1,720,733 SH   SOLE   1,720,733 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,263 550,000 SH Put SOLE   550,000 0 0
BIOGEN INC COM 09062X103 508 2,412 SH   SOLE   2,412 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 244,420 2,061,402 SH   SOLE   2,061,402 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 212 20,000 SH Put SOLE   20,000 0 0
CENTENE CORP DEL COM 15135B101 1,485 300,000 SH Put SOLE   300,000 0 0
CODIAK BIOSCIENCES INC COM 192010106 3,164 504,602 SH   SOLE   504,602 0 0
CONTRAFECT CORP COM NEW 212326300 7,133 1,954,222 SH   SOLE   1,954,222 0 0
DERMTECH INC COM 24984K105 9,585 652,907 SH   SOLE   652,907 0 0
DERMTECH INC COM 24984K105 921 193,800 SH Put SOLE   193,800 0 0
DIREXION SHS ETF TR SP BIOTCH BL NEW 25490K323 1,775 1,000,000 SH Put SOLE   1,000,000 0 0
FORIAN INC COM 34630N106 8,784 1,262,040 SH   SOLE   1,262,040 0 0
IMMUNITYBIO INC COM 45256X103 2,244 400,013 SH   SOLE   400,013 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 2,675 976,156 SH   SOLE   976,156 0 0
OPKO HEALTH INC COM 68375N103 30,911 8,985,756 SH   SOLE   8,985,756 0 0
OPKO HEALTH INC COM 68375N103 292 749,900 SH Put SOLE   749,900 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 11,151 1,225,395 SH   SOLE   1,225,395 0 0
PFIZER INC COM 717081103 1,265 550,000 SH Put SOLE   550,000 0 0
PROTAGENIC THERAPEUTICS INC COM 74365N103 16 20,000 SH   SOLE   20,000 0 0
QUIDEL CORP COM 74838J101 79,693 708,631 SH   SOLE   708,631 0 0
QUIDEL CORP COM 74838J101 200 26,500 SH Put SOLE   26,500 0 0
SEMA4 HOLDINGS CORP COM CL A 81663L101 12,111 3,944,832 SH   SOLE   3,944,832 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 475 2,132,000 SH   SOLE   2,132,000 0 0
VERTEX ENERGY INC COM 92534K107 547 55,000 SH   SOLE   55,000 0 0