The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 18,936 3,627,549 SH   SOLE   3,627,549 0 0
AGENUS INC COM NEW 00847G705 29,322 9,106,132 SH   SOLE   9,106,132 0 0
AGENUS INC COM NEW 00847G705 22 298,300 SH Put SOLE   298,300 0 0
ANTARES PHARMA INC COM 036642106 6,140 1,720,000 SH   SOLE   1,720,000 0 0
ARK ETF TR GENOMIC REV ETF 00214Q302 1,076 350,000 SH Put SOLE   350,000 0 0
ASPIRA WOMENS HEALTH INC COM 04537Y109 9,818 5,547,094 SH   SOLE   5,547,094 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 23,140 1,670,733 SH   SOLE   1,670,733 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,383 700,000 SH Put SOLE   700,000 0 0
BIOGEN INC COM 09062X103 579 2,412 SH   SOLE   2,412 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 286,011 2,075,402 SH   SOLE   2,075,402 0 0
CENTENE CORP DEL COM 15135B101 531 416,300 SH Put SOLE   416,300 0 0
CODIAK BIOSCIENCES INC COM 192010106 7,343 659,191 SH   SOLE   659,191 0 0
CONTRAFECT CORP COM NEW 212326300 5,135 1,952,422 SH   SOLE   1,952,422 0 0
CROSS CTRY HEALTHCARE INC COM 227483104 1,971 71,000 SH   SOLE   71,000 0 0
DERMTECH INC COM 24984K105 9,526 602,907 SH   SOLE   602,907 0 0
DERMTECH INC COM 24984K105 425 250,000 SH Put SOLE   250,000 0 0
FORIAN INC COM 34630N106 11,001 1,219,661 SH   SOLE   1,219,661 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 3,202 976,156 SH   SOLE   976,156 0 0
MOTUS GI HLDGS INC COM 62014P108 49 105,885 SH   SOLE   105,885 0 0
OPKO HEALTH INC COM 68375N103 58,774 12,219,073 SH   SOLE   12,219,073 0 0
OPKO HEALTH INC COM 68375N103 685 757,300 SH Put SOLE   757,300 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 29,120 1,420,652 SH   SOLE   1,420,652 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 126 67,000 SH Put SOLE   67,000 0 0
PFIZER INC COM 717081103 28,049 475,000 SH   SOLE   475,000 0 0
PFIZER INC COM 717081103 15,041 1,400,000 SH Put SOLE   1,400,000 0 0
PROTAGENIC THERAPEUTICS INC COM 74365N103 416 300,267 SH   SOLE   300,267 0 0
QUIDEL CORP COM 74838J101 115,426 855,068 SH   SOLE   855,068 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 874 2,132,000 SH   SOLE   2,132,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 1,308 500,000 SH Put SOLE   500,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 36,050 861,008 SH   SOLE   861,008 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 1,577 287,600 SH Put SOLE   287,600 0 0
XBIOTECH INC COM 98400H102 674 500,000 SH Put SOLE   500,000 0 0