The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 21,869 3,751,121 SH   SOLE   3,751,121 0 0
AGENUS INC COM NEW 00847G705 49,546 9,437,334 SH   SOLE   9,437,334 0 0
AGENUS INC COM NEW 00847G705 53 100,000 SH Call SOLE   100,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 4,276 838,403 SH   SOLE   838,403 0 0
ANTARES PHARMA INC COM 036642106 6,916 1,900,000 SH   SOLE   1,900,000 0 0
ASPIRA WOMENS HEALTH INC COM 04537Y109 28,103 8,647,094 SH   SOLE   8,647,094 0 0
ATEA PHARMACEUTICALS INC COM 04683R106 10,838 309,126 SH   SOLE   309,126 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 27,601 1,920,733 SH   SOLE   1,920,733 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 176 150,000 SH Call SOLE   150,000 0 0
BIODESIX INC COM 09075X108 1,486 180,833 SH   SOLE   180,833 0 0
BIOGEN INC COM 09062X103 683 2,412 SH   SOLE   2,412 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 295,053 2,124,055 SH   SOLE   2,124,055 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 2,168 80,000 SH Call SOLE   80,000 0 0
CODIAK BIOSCIENCES INC COM 192010106 11,431 700,000 SH   SOLE   700,000 0 0
CONTRAFECT CORP COM NEW 212326300 6,840 1,688,902 SH   SOLE   1,688,902 0 0
DERMTECH INC COM 24984K105 19,661 612,307 SH   SOLE   612,307 0 0
FORIAN INC COM 34630N106 12,384 1,199,960 SH   SOLE   1,199,960 0 0
GUARDANT HEALTH INC COM 40131M109 8,751 70,000 SH   SOLE   70,000 0 0
IMMUTEP LTD SPONSORED ADS 45257L108 3,870 1,000,000 SH   SOLE   1,000,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 895 300,000 SH Put SOLE   300,000 0 0
LILLY ELI & CO COM 532457108 680 100,000 SH Call SOLE   100,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 3,072 38,500 SH   SOLE   38,500 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 426 63,000 SH Call SOLE   63,000 0 0
MOTUS GI HLDGS INC COM 62014P108 2,032 2,947,551 SH   SOLE   2,947,551 0 0
OPKO HEALTH INC COM 68375N103 46,790 12,819,073 SH   SOLE   12,819,073 0 0
OPKO HEALTH INC COM 68375N103 145 473,800 SH Call SOLE   473,800 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 36,919 1,444,959 SH   SOLE   1,444,959 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 50 43,700 SH Call SOLE   43,700 0 0
PFIZER INC COM 717081103 98 750,000 SH Call SOLE   750,000 0 0
PROTAGENIC THERAPEUTICS INC COM 74365N103 935 500,000 SH   SOLE   500,000 0 0
QUIDEL CORP COM 74838J101 127,974 906,655 SH   SOLE   906,655 0 0
SELECT MED HLDGS CORP COM 81619Q105 5,414 149,678 SH   SOLE   149,678 0 0
SELECT MED HLDGS CORP COM 81619Q105 193 26,100 SH Call SOLE   26,100 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 1,971 2,132,000 SH   SOLE   2,132,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 1,556 250,000 SH Put SOLE   250,000 0 0
VERTEX ENERGY INC COM 92534K107 472 90,000 SH   SOLE   90,000 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 51,413 1,181,357 SH   SOLE   1,181,357 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 1,197 383,700 SH Call SOLE   383,700 0 0
XBIOTECH INC COM 98400H102 275 350,000 SH   SOLE   350,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 9,008 315,642 SH   SOLE   315,642 0 0