X0306 4 2018-07-09 0 0001012477 AVADEL PHARMACEUTICALS PLC AVDL 0001207106 STAPLETON CRAIG R BLOCK 10-1, BLANCHARDSTOWN CORPORATE PARK, BALLYCOOLIN DUBLIN L2 15 IRELAND 1 0 0 0 ADSs 2018-07-09 4 A 0 57315 0 A 350328 D ADSs 210400 I By Spouse Warrants (right to buy) 21.67 2016-06-26 2019-06-26 ADSs 117449 117449 D Warrants (right to buy) 13.59 2017-08-10 2020-08-10 ADSs 117449 117449 D Stock Option (right to buy) 10.51 2018-06-28 2022-06-28 ADSs 35000 35000 D The issuer's "ADSs" are American Depositary Shares, with each ADS representing one ordinary share, nominal value $0.01 per share, of the issuer; ADSs may be represented by American Depositary Receipts. Represents 57,315 restricted ADSs granted under the issuer's Omnibus Incentive Compensation Plan on 07/09/2018; one-third (1/3) of the ADSs will vest on each of the first three anniversaries of the grant date. The filing of this statement shall not be construed as an admission that the reporting person is, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, the beneficial owner of these securities. Warrants were granted 06/26/2015 but were not exercisable until the first anniversary of the date of grant; on such first anniversary the warrants became exercisable for a 3-year period as to all 117,449 ADSs. The warrant exercise price per ADS may be paid in U.S. Dollars as shown in Item 2 of Table II or in Euros based on the exchange rate prevailing on the date of grant, or (euro)19.34 per ADS. Warrants were granted 08/10/2016 but were not exercisable until the first anniversary of the date of grant; on such first anniversary the warrants became exercisable for a 3-year period as to all 117,449 ADSs. The warrant exercise price per ADS may be paid in U.S. Dollars as shown in Item 2 of Table II or in Euros based on the exchange rate prevailing on the date of grant, or (euro) 12.16 per ADS. Options became exercisable as to all 35,000 ADSs on the first anniversary of the 06/28/2017 grant date. /s/ Phillandas T. Thompson, as attorney-in-fact for Craig R. Stapleton 2018-07-11