Consolidated Statements of Shareholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	Ordinary Shares	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive Loss
Beginning balance at Dec. 31, 2013	$ (8,819)	$ 3,746	$ 211,473	$ (234,853)	$ 10,815
Balance (in shares) at Dec. 31, 2013		25,613
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(85,469)			(85,469)
Other comprehensive loss	(18,238)				(18,238)
Subscription of warrants	351		351
Exercise of stock options or warrants	6,025	$ 164	5,861
Exercise of stock options or warrants (in shares)		1,001
Vesting of free shares	0	$ 24	(24)
Vesting of free shares (in shares)		151
Stock-based compensation expense	2,894		2,894
Public offering	115,232	$ 2,099	113,133
Public offering (in shares)		12,400
Shares granted to Recipharm AB	13,049	$ 155	12,894
Shares granted to Recipharm AB (in shares)		1,026
Ending balance at Dec. 31, 2014	25,025	$ 6,188	346,582	(320,322)	(7,423)
Balance (in shares) at Dec. 31, 2014		40,191
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	41,798			41,798
Other comprehensive loss	(15,234)				(15,234)
Subscription of warrants	601		601
Exercise of stock options or warrants	6,389	$ 123	6,266
Exercise of stock options or warrants (in shares)		899
Vesting of free shares	0	$ 20	(20)
Vesting of free shares (in shares)		151
Stock-based compensation expense	7,741		7,741
Excess tax benefit from stock-based compensation	2,814		2,814
Ending balance at Dec. 31, 2015	69,134	$ 6,331	363,984	(278,524)	(22,657)
Balance (in shares) at Dec. 31, 2015		41,241
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(41,276)			(41,276)
Other comprehensive loss	(908)				(908)
Subscription of warrants	326		326
Exercise of stock options or warrants	114	$ 2	112
Exercise of stock options or warrants (in shares)		15
Vesting of free shares	0	$ 18	(18)
Vesting of free shares (in shares)		115
Stock-based compensation expense	14,679		14,679
Cross-border merger nominal value adjustment	0	$ (5,937)	5,937
Ending balance at Dec. 31, 2016	$ 42,069	$ 414	$ 385,020	$ (319,800)	$ (23,565)
Balance (in shares) at Dec. 31, 2016		41,371