Consolidated Statements of Income (Loss) - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product sales and services	$ 147,222,000	$ 172,288,000	$ 12,193,000
License and research revenue	3,024,000	721,000	2,782,000
Total	150,246,000	173,009,000	14,975,000
Operating expenses:
Cost of products and services sold	13,248,000	11,410,000	3,383,000
Research and development	34,611,000	25,608,000	17,298,000
Selling, general and administrative	44,179,000	21,712,000	15,698,000
Intangible asset amortization	13,888,000	12,564,000	11,749,000
Changes in fair value of related party contingent consideration	49,285,000	30,957,000	57,491,000
Loss on early repayment of related party acquisition-related note	0	0	3,013,000
Total	155,211,000	102,251,000	108,632,000
Operating income (loss)	(4,965,000)	70,758,000	(93,657,000)
Investment and other income	1,635,000	1,236,000	927,000
Interest expense	(963,000)	0	(5,747,000)
Other expense - changes in fair value of related party payable	(6,548,000)	(4,883,000)	(3,525,000)
Foreign exchange gain	1,123,000	10,594,000	11,871,000
Income (loss) before income taxes	(9,718,000)	77,705,000	(90,131,000)
Income tax provision (benefit)	31,558,000	35,907,000	(644,000)
Net income (loss) from continuing operations	(41,276,000)	41,798,000	(89,487,000)
Net income from discontinued operations	0	0	4,018,000
Net income (loss)	$ (41,276,000)	$ 41,798,000	$ (85,469,000)
Earnings (loss) per share - basic:
Continuing operations (in usd per share)	$ (1.00)	$ 1.03	$ (2.47)
Discontinued operations (in usd per share)	0.00	0.00	0.11
Net income (loss) (in usd per share)	(1.00)	1.03	(2.36)
Earnings (loss) per share - diluted:
Continuing operations (in usd per share)	(1.00)	0.96	(2.47)
Discontinued operations (in usd per share)	0.00	0.00	0.11
Net income (loss) (in usd per share)	$ (1.00)	$ 0.96	$ (2.36)
Earnings (loss) per share
Weighted average number of shares outstanding - basic (in shares)	41,248	40,580	36,214
Weighted average number of shares outstanding - diluted (in shares)	41,248	43,619	36,214