Discontinued Operations (Details Textual) - USD ($)	1 Months Ended	3 Months Ended	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2014	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Discontinued Operations [Line Items]
Gain on disposal			$ 0	$ 0	$ 5,007,000
Stock issued, value, acquisition					13,049,000
Initial noncancellable term of master agreement	5 years
Percentage of margin on costs incurred on services	20.00%
Minimum amount on supply and services of products	$ 22,500,000		22,500,000
Research and development expense			34,611,000	25,608,000	$ 17,298,000
Recipharm AB | Equity securities
Discontinued Operations [Line Items]
Stock issued, value, acquisition	13,000,000
MSA
Discontinued Operations [Line Items]
Research and development expense			4,541,000	4,089,000
Services delivered and commitments satisfied			$ 939,000	$ 5,679,000
Discontinued Operations, Held-for-sale or Disposed of by Sale | Pessac Business
Discontinued Operations [Line Items]
Proceeds from divestiture of businesses	13,200,000
Contribution for potential employee obligations	$ 700,000
Gain on disposal		$ 5,007,000