-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 QOZJA11BO8o/loy9QEfFWPOwsK8ItfY5tgKPjmkM5YcBskgxxCXcRwE+L9d2bQ7M
 tUmQIUEqEA0Ijct2XybDsA==

<SEC-DOCUMENT>0001181431-05-017652.txt : 20050317
<SEC-HEADER>0001181431-05-017652.hdr.sgml : 20050317
<ACCEPTANCE-DATETIME>20050317175459
ACCESSION NUMBER:		0001181431-05-017652
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050310
FILED AS OF DATE:		20050317
DATE AS OF CHANGE:		20050317

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Powell Andrew Kenneth William
		CENTRAL INDEX KEY:			0001304113

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-28308
		FILM NUMBER:		05689969

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		215-579-7388

	MAIL ADDRESS:	
		STREET 1:		C/O COLLAGENEX PHARMACEUTICALS, INC.
		STREET 2:		41 UNIVERSITY DRIVE
		CITY:			NEWTOWN
		STATE:			PA
		ZIP:			18940

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			COLLAGENEX PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001012270
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521758016
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		41 UNIVERSITY DRIVE
		CITY:			NEWTON
		STATE:			PA
		ZIP:			18940
		BUSINESS PHONE:		2155797388

	MAIL ADDRESS:	
		STREET 1:		41 UNIVERSITY DRIVE
		CITY:			NEWTON
		STATE:			PA
		ZIP:			18940
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd72655.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-03-10</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001012270</issuerCik>
        <issuerName>COLLAGENEX PHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>CGPI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001304113</rptOwnerCik>
            <rptOwnerName>Powell Andrew Kenneth William</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>COLLAGENEX PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>41 UNIVERSITY DRIVE, SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>NEWTOWN</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>18940</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>VP, G. Counsel and Corp. Sec.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Options to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>5.67</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-03-10</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>5700</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2006-03-10</value>
            </exerciseDate>
            <expirationDate>
                <value>2010-03-09</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5700</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>75700</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents options granted by the Issuer pursuant to its 1996 Stock Option Plan on March 10, 2005. The options vest as follows: 1,140 shares subject to such options vest on March 10, 2006, 1,140 shares subject to such options vest on March 10, 2007, 1,140 shares subject to such options vest on March 10, 2008, 1,140 shares subject to such options vest on March 10, 2009 and 1,140 shares subject to such options vest on March 10, 2010.</footnote>
        <footnote id="F2">Includes multiple options grants with different prices and vesting dates.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Andrew K.W. Powell</signatureName>
        <signatureDate>2005-03-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----