X0202 4 2007-08-30 0 0001012140 ONYX PHARMACEUTICALS INC ONXX 0001197355 FUCHS HENRY J C/O ONYX PHARMACEUTICALS, INC. 2100 POWELL ST., 12TH FLOOR EMERYVILLE CA 94608 0 1 0 0 EVP & Chief Medical Officer Common Stock 2007-08-30 4 M 0 25000 21.01 A 42292 D Common Stock 2007-08-30 4 S 0 600 38.45 D 41692 D Common Stock 2007-08-30 4 S 0 100 38.43 D 41592 D Common Stock 2007-08-30 4 S 0 1100 38.41 D 40492 D Common Stock 2007-08-30 4 S 0 200 38.40 D 40292 D Common Stock 2007-08-30 4 S 0 300 38.39 D 39992 D Common Stock 2007-08-30 4 S 0 200 38.38 D 39792 D Common Stock 2007-08-30 4 S 0 494 38.37 D 39298 D Common Stock 2007-08-30 4 S 0 500 38.35 D 38798 D Common Stock 2007-08-30 4 S 0 200 38.33 D 38598 D Common Stock 2007-08-30 4 S 0 200 38.32 D 38398 D Common Stock 2007-08-30 4 S 0 1100 38.31 D 37298 D Common Stock 2007-08-30 4 S 0 306 38.30 D 36992 D Common Stock 2007-08-30 4 S 0 606 38.28 D 36386 D Common Stock 2007-08-30 4 S 0 2600 38.27 D 33786 D Common Stock 2007-08-30 4 S 0 1400 38.25 D 32386 D Common Stock 2007-08-30 4 S 0 1200 38.24 D 31186 D Common Stock 2007-08-30 4 S 0 2600 38.23 D 28586 D Common Stock 2007-08-30 4 S 0 500 38.21 D 28086 D Common Stock 2007-08-30 4 S 0 3891 38.20 D 24195 D Common Stock 2007-08-30 4 S 0 6903 38.19 D 17292 D Stock Option (Right to Buy) 21.01 2007-08-30 4 M 0 25000 0.00 D 2015-09-13 Common Stock 25000 250000 D Twenty-Five percent of the shares subject to the option vest one year from the date of grant and vest at a rate of 1/48th per month thereafter. /s/ Gregory Giotta, Attorney-in-fact 2007-08-30