X0202 4 2006-02-06 0 0001012140 ONYX PHARMACEUTICALS INC ONXX 0001187333 RENTON HOLLINGS C/O ONYX PHARMACEUTICALS, INC. 2100 POWELL ST., 12TH FLOOR EMERYVILLE CA 94608 1 1 0 0 President and CEO Common Stock 2006-02-06 4 M 0 2500 4.18 A 22748 I Family Trust Common Stock 2006-02-06 4 S 0 2500 27.91 D 20248 I Family Trust Stock Option (Right to Buy) 4.18 2006-02-06 4 M 0 2500 0.00 D 2012-08-12 Common Stock 2500 115000 D Reporting person is deemed to beneficially own an addtional (i) 1,200 shares held by his spouse and (ii) 10,737 shares held by him directly. The shares subject to the grant are immediately exercisable upon grant but are subject to the following vesting schedule: 12.5% of the shares subject to the option vest 6 months following the date of grant. The remaining shares vest in equal monthly installments over the following 42 months for a total vesting schedule of 48 months. /s/ Marilyn E. Wortzman, Attorney-in-fact 2006-02-06