-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 OpFFbegLgBA2Br9jiqnn3As2o0le/ct+6CtHzVZtZHcvaAr9RwXzj91MFbHAK+vI
 nHwkZCuI31js7yjj1lLlwA==

<SEC-DOCUMENT>0001209191-03-033346.txt : 20031203
<SEC-HEADER>0001209191-03-033346.hdr.sgml : 20031203
<ACCEPTANCE-DATETIME>20031203133340
ACCESSION NUMBER:		0001209191-03-033346
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031202
FILED AS OF DATE:		20031203

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			JEW JEANNE Y
		CENTRAL INDEX KEY:			0001235946

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-28298
		FILM NUMBER:		031034817

	BUSINESS ADDRESS:	
		STREET 1:		C/O ONYX PHARMECEUTICALS INC
		STREET 2:		3031 RESEARCH DR BLDG A
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94806
		BUSINESS PHONE:		5102229700

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ONYX PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0001012140
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				943154463
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3031 RESEARCH DR
		STREET 2:		BLDG A
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94806
		BUSINESS PHONE:		5102229700

	MAIL ADDRESS:	
		STREET 1:		3031 RESEARCH DRIVE
		CITY:			RICHMOND
		STATE:			CA
		ZIP:			94806
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
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volved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>400.0000</value></transactionShares><transactionPricePerShare><value>29.4600</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>6325.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-12-02</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionT
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PerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>300.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-12-02</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>200.0000</value></transactionShares><transactionPricePerShare><value>29.4000</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredD
isposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>100.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-12-02</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>100.0000</value></transactionShares><transactionPricePerShare><value>29.3200</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTr
ansaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction></nonDerivativeTable><derivativeTable><derivativeTransaction><securityTitle><value>Stock Option (Right to Buy)</value></securityTitle><conversionOrExercisePrice><value>6.4600</value></conversionOrExercisePrice><transactionDate><value>2003-12-02</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>15000.0000</value></transactionShares><transactionPricePerShare><value>0</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDat
e><value>2003-11-25</value><footnoteId id="F1" /></exerciseDate><expirationDate><value>2013-11-25</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>15000.0000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>85000.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">The option becomes exercisable as to 25% on the first anniversary of the date of grant and 1/48th monthly thereafter.</footnote></footnotes><remarks></remarks><ownerSignature><signatureName>/s/ Marilyn E. Wortzman, Attorney-in-fact</signatureName><signatureDate>2003-12-02</signatureDate></ownerSignature></ownershipDocument>

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</SEC-DOCUMENT>
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