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Fair Value Measurements (Details 3) (USD $)
3 Months Ended 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Jun. 30, 2013
Jun. 30, 2012
Summary of the changes in the fair value of the non-current liability for contingent consideration:        
Change in valuation $ (3,022,000) $ (53,214,000) $ (5,952,000) $ (56,392,000)
Convertible senior notes due 2016
       
Summary of the changes in the fair value of the non-current liability for contingent consideration:        
Estimated fair value of senior notes 520,500,000   520,500,000  
Proteolix
       
Liability for contingent consideration        
Milestone payment based on the accelerated marketing approval of related parties, low end 0   0  
Milestone payment based on the accelerated marketing approval of related parties, high end 365,000,000   365,000,000  
Change in contingent considerations liability by 1% percentage increase or decrease in probability of occurrence of each milestone     2,500,000  
Percent change to evaluate change in the contingent considerations liability     1.00%  
Summary of the changes in the fair value of the non-current liability for contingent consideration:        
Fair value at beginning of period 152,093,000 163,168,000 149,163,000 159,990,000
Change in valuation 3,022,000 53,214,000 5,952,000 56,392,000
Fair value at end of period $ 155,115,000 $ 216,382,000 $ 155,115,000 $ 216,382,000