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Fair Value Measurements (Details 3) (USD $)
3 Months Ended
Mar. 31, 2013
Mar. 31, 2012
Summary of the changes in the fair value of the non-current liability for contingent consideration:    
Change in valuation $ (2,930,000) $ (3,178,000)
Convertible senior notes due 2016
   
Summary of the changes in the fair value of the non-current liability for contingent consideration:    
Estimated fair value of senior notes 537,000,000  
Proteolix
   
Liability for contingent consideration    
Milestone payment based on the accelerated marketing approval of related parties, high end 365,000,000  
Milestone payment based on the accelerated marketing approval of related parties, low end 0  
Change in contingent considerations liability by 1% percentage increase or decrease in probability of occurrence of each milestone 2,400,000  
Percent change to evaluate change in the contingent considerations liability 1.00%  
Summary of the changes in the fair value of the non-current liability for contingent consideration:    
Fair value at beginning of period 149,163,000 159,990,000
Change in valuation 2,930,000 3,178,000
Fair value at end of period $ 152,093,000 $ 163,168,000