Stock-Based Compensation (Details 7) (USD $)	12 Months Ended					0 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2012 Performance restricted stock units	Dec. 31, 2011 Performance restricted stock units	Jul. 20, 2012 Performance restricted stock units Kyprolis
Employee stock-based compensation
Compensation expense	$ 35,326,000	$ 26,390,000	$ 22,117,000	$ 3,200,000
Potential shares of restricted stock awards				218,825	205,500
Total unrecorded stock-based compensation expense for unvested stock options shares, net of expected forfeitures				$ 8,200,000
Summary of status of the Company's non-vested restricted stock awards
Restricted Stock Awards, Shares, Beginning Balance				205,500
Restricted Stock Awards, Shares, Granted				238,475	205,500
Restricted Stock Awards, Shares, Vested				(91,500)		(86,500)
Restricted Stock Awards, Shares, Cancelled				(133,650)
Restricted Stock Awards, Shares, Ending Balance				218,825	205,500
Weighted Average Grant Date Fair Value, Beginning Balance (in dollars per share)				$ 35.23
Weighted Average Grant Date Fair Value, Granted (in dollars per share)				$ 38.15	$ 35.23
Weighted Average Grant Date Fair Value, Vested (in dollars per share)				$ 35.23
Weighted Average Grant Date Fair Value, Cancelled (in dollars per share)				$ 35.52
Weighted Average Grant Date Fair Value, Ending Balance (in dollars per share)				$ 38.24	$ 35.23