Stock-Based Compensation (Details) (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Employee stock-based compensation
Share-based compensation expense	$ 35,326	$ 26,390	$ 22,117
Impact on net income (loss) per share amounts:
Decrease in basic net income (loss) per share (in dollars per share)	$ 0.54	$ 0.42	$ 0.35
Decrease in diluted net income (loss) per share (in dollars per share)	$ 0.54	$ 0.41	$ 0.35
Weighted Average Number of Shares (Basic)	65,148	63,422	62,618
Weighted Average Shares (Diluted)	65,148	64,010	62,618
Non-employee Directors
Employee stock-based compensation
Share-based compensation expense	2,600	600	700
Cost of goods sold \| Employees
Employee stock-based compensation
Share-based compensation expense	6
Research and development \| Employees
Employee stock-based compensation
Share-based compensation expense	9,296	6,269	4,252
Selling, general and administrative \| Employees
Employee stock-based compensation
Share-based compensation expense	$ 26,024	$ 20,121	$ 17,865

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period.

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- Definition

Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

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Reference 2: http://www.xbrl.org/2003/role/presentationRef

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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 5: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Emerging Issues Task Force (EITF)

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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 6: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 7: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

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+ Details