Quarterly Financial Data (Unaudited) (Tables)

12 Months Ended

Dec. 31, 2012

Quarterly Financial Data (Unaudited)

Quarterly financial data

	2012 Quarter Ended
	December 31			September 30			June 30			March 31
	(In thousands, except per share data)
Revenue:
Revenue from collaboration agreement	$	72,936		$	70,744		$	72,704		$	72,031
Product revenue		45,319			18,636			-			-
Royalty revenue		8,163			131			-			-
Contract revenue from collaborations		1,500			-			-			-
Total revenue		127,918			89,511			72,704			72,031
Operating expenses:
Cost of goods sold (excludes amortization of certain intangible assets)		832			496			-			-
Research and development		82,572			85,667			76,356			80,660
Selling, general and administrative		74,566			61,747			48,907			38,944
Contingent consideration expense (benefit)		2,937			9,843			53,214			3,178
Intangible asset amortization		5,221			4,110			-			-
Total operating expenses		166,128			161,863			178,477			122,782
Income (loss) from operations		(38,210	)		(72,352	)		(105,773	)		(50,751	)
Investment income, net		675			625			619			758
Interest expense		(5,659	)		(5,456	)		(5,374	)		(5,296	)
Other income (expense)		(728	)		(1,194	)		4,464			(905	)
Provision (benefit) for income taxes		(1,000	)		(95,773	)		(15	)		18
Net income (loss)		(42,922	)		17,396			(106,049	)		(56,212	)
Basic net income (loss) per share	$	(0.64	)	$	0.26		$	(1.65	)	$	(0.88	)
Diluted net income (loss) per share	$	(0.64	)	$	0.25		$	(1.65	)	$	(0.88	)

	2011 Quarter Ended
	December 31			September 30			June 30			March 31
	(In thousands, except per share data)
Revenue:
Revenue from collaboration agreement	$	76,821		$	75,041		$	67,956		$	67,145
Contract revenue from collaborations		160,211			-			-			-
Total revenue		237,032			75,041			67,956			67,145
Operating expenses:
Research and development		83,990			58,532			63,045			62,494
Selling, general and administrative		52,611			42,642			38,236			34,471
Contingent consideration expense (benefit)		(116,663	)		5,945			5,755			11,495
Lease termination exit costs		(4,540	)		130			10,727			-
Total operating expenses		15,398			107,249			117,763			108,460
Income (loss) from operations		221,634			(32,208	)		(49,807	)		(41,315	)
Investment income, net		678			435			645			649
Interest expense		(5,069	)		(5,112	)		(5,041	)		(5,002	)
Other income (expense)		(326	)		25			(340	)		(3,462	)
Provision (benefit) for income taxes		242			-			-			32
Net income (loss)	$	216,675		$	(36,860	)	$	(54,543	)	$	(49,162	)
Basic net income (loss) per share	$	3.40		$	(0.58	)	$	(0.86	)	$	(0.78	)
Diluted net income (loss) per share	$	3.16		$	(0.58	)	$	(0.86	)	$	(0.78	)