Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2012

Stock-Based Compensation

Employee stock-based compensation

	Year Ended December 31,
	2012		2011		2010
	(In thousands except per share data)
Cost of goods sold	$	6	$	-	$	-
Research and development		9,296		6,269		4,252
Selling, general and administrative		26,024		20,121		17,865
Total share-based compensation expense	$	35,326	$	26,390	$	22,117
Impact on net income (loss) per share amounts:
Decrease in basic net income (loss) per share	$	0.54	$	0.42	$	0.35
Decrease in diluted net income (loss) per share	$	0.54	$	0.41	$	0.35
Weighted Average Shares (Basic)		65,148		63,422		62,618
Weighted Average Shares (Diluted)		65,148		64,010		62,618

Summary of stock option activity under all option plans

	Year Ended December 31,
	2012	2011	2010
Stock Option Plans:
Risk-free interest rate	0.78%	1.92%	2.06%
Expected life	4.5 years	4.4 years	4.4 years
Expected volatility	50%	53%	55%
Expected dividends	None	None	None
Weighted average option fair value	$20.32	$15.77	$13.12
Restricted stock awards and units:
Expected life	3 years	3 years	3 years
Expected dividends	None	None	None
Weighted average fair value per share	$42.91	$32.75	$29.92
ESPP:
Risk-free interest rate	0.10%	0.14%	0.18%
Expected life	6 months	6 months	6 months
Expected volatility	51%	42%	46%
Expected dividends	None	None	None
Weighted average fair value per share	$15.89	$9.76	$6.25

Stock option and award activity under employee stock options plans

Employee stock options:	Number of Shares Outstanding			Weighted Average Exercise Price
Balance at December 31, 2009		5,068,110			$29.48
Granted		2,013,989			$28.57
Exercised		(323,436	)		$21.22
Expired		(98,172	)		$34.69
Forfeited		(386,020	)		$30.36
Balance at December 31, 2010		6,274,471
Granted		1,966,456			$35.34
Exercised		(819,370	)		$26.99
Expired		(51,011	)		$46.07
Forfeited		(436,749	)		$30.02
Balance at December 31, 2011		6,933,797
Granted		2,436,630			$49.73
Exercised		(2,490,484	)		$30.65
Expired		(70,945	)		$32.58
Forfeited		(400,483	)		$34.82
Balance at December 31, 2012		6,408,515

Options outstanding and exercisable for stock-based payment awards

Options Outstanding							Options Exercisable
Range of Exercise Prices	Number Outstanding		Weighted Average Contractual Life Remaining (In years)		Weighted Average Exercise Price		Number Exercisable		Weighted Average Exercise Price
$11.85 - $29.03		1,394,052		5.5		$26.05		1,108,933		$26.03
$29.12 - $34.48		1,335,042		6.9		$31.39		796,788		$31.37
$34.51 - $37.68		1,953,665		8.4		$36.47		551,483		$36.01
$37.85 - $67.24		1,294,457		8.6		$48.53		223,893		$45.64
$67.38 - $91.38		431,299		9.7		$76.94		2,223		$68.11
Total		6,408,515		7.6		$38.30		2,683,320		$31.34

Summary of stock award activity under option plans

Restricted stock awards and units:	Shares			Weighted Average Grant Date Fair Value
Balance at December 31, 2009		368,641			$29.12
Granted		250,464			$29.68
Vested		(172,870	)		$28.74
Cancelled		(54,713	)		$28.94
Balance at December 31, 2010		391,522			$28.91
Granted		232,383			$35.03
Vested		(191,012	)		$29.66
Cancelled		(42,125	)		$30.80
Balance at December 31, 2011		390,768			$32.75
Granted		282,167			$42.91
Vested		(191,856	)		$32.09
Cancelled		(51,711	)		$34.60
Balance at December 31, 2012		429,368			$39.50

Summary of non-vested restricted stock awards

Performance restricted stock units:	Shares			Weighted Average Grant Date Fair Value
Balance at December 31, 2010		-			-
Granted		205,500			$35.23
Vested		-			-
Cancelled		-			-
Balance at December 31, 2011		205,500			$35.23
Granted		238,475			$38.15
Vested		(91,500	)		$35.23
Cancelled		(133,650	)		$35.52
Balance at December 31, 2012		218,825			$38.24