Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $) In Thousands	6 Months Ended
Jun. 30, 2011	Jun. 30, 2010
Cash flows from operating activities:
Net loss	$ (103,703)	$ (109,227)
Adjustments to reconcile net loss to net cash used in operating activities:
Realized gains on sales of current marketable securities	(1)	(55)
Depreciation and amortization	741	1,324
Stock-based compensation	14,152	10,948
Amortization of convertible senior notes discount and debt issuance costs	4,944	4,691
Changes in fair value of liability for contingent consideration	17,250	95,485
Property and equipment write-off	732
Impairment of equity investment	3,000
Changes in operating assets and liabilities:
Restricted cash		(14)
Receivable from collaboration partners	533	(876)
Prepaid expenses and other current assets	(2,350)	913
Other assets	14,573	(19,293)
Accounts payable	7	1,245
Accrued liabilities	(1,593)	(407)
Accrued clinical trials and related expenses	3,797	(1,618)
Accrued compensation	(1,052)	(6,320)
Escrow liability	(31,634)	14
Lease termination exit costs liability	13,087
Other liabilities	5,610	(431)
Net cash used in operating activities	(61,907)	(23,621)
Cash flows from investing activities:
Purchases of marketable securities	(260,094)	(236,612)
Sales of marketable securities	80,280	248,255
Maturities of marketable securities	149,750	245,010
Transfers from restricted cash	31,910	(4,000)
Payment for liability for contingent consideration, current		(36,000)
Capital expenditures	(9,221)	(267)
Net cash provided by investing activities	(7,375)	216,386
Cash flows from financing activities:
Repurchases of restricted stock awards	(180)	(45)
Net proceeds from issuances of common stock	11,865	3,735
Net cash provided by financing activities	11,685	3,690
Net increase (decrease) in cash and cash equivalents	(57,597)	196,455
Cash and cash equivalents at beginning of period	226,340	107,668
Cash and cash equivalents at end of period	168,743	304,123
Supplemental cash flow data
Cash paid during the period for income taxes
Cash paid during the period for interest	$ 4,600	$ 4,677

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