The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101   298 2,836 SH   DFND   2,260 0 576
ABBOTT LABORATORIES COM 002824100   271 2,680 SH   DFND   2,479 0 201
ABBVIE INC COM COM 00287Y109   30,988 194,443 SH   DFND   190,295 0 4,147
ACCENTURE PLC COM g1151c101   17,563 61,451 SH   DFND   60,244 0 1,207
ACTIVISION BLIZZARD INC COM 00507v109   234 2,738 SH   DFND   2,523 0 215
AEGLEA BIOTHERAPEUTICS INC COM 00773j103   31 105,800 SH   DFND   105,300 0 500
AEGON NV - AMER REG SHS COM 007924103   197 45,710 SH   DFND   45,710 0 0
AFLAC INC COM COM 001055102   19,506 302,325 SH   DFND   296,360 0 5,965
ALPHABET INC CAP STK CL A COM 02079k305   3,375 32,537 SH   DFND   32,537 0 0
ALPHABET INC CAP STK CL C COM 02079k107   38,146 366,786 SH   DFND   362,921 0 3,865
ALTRIA GROUP INC COM 02209s103   852 19,089 SH   DFND   19,089 0 0
AMAZON.COM INC COM 023135106   25,609 247,929 SH   DFND   245,629 0 2,300
AMER ELEC PWR INC COM COM 025537101   672 7,390 SH   DFND   7,390 0 0
AMERICAN EXPRESS CO COM COM 025816109   31,951 193,702 SH   DFND   190,641 0 3,061
AMGEN INC COM COM 031162100   9,219 38,136 SH   DFND   36,666 0 1,470
APPLE INC COM COM 037833100   68,902 417,843 SH   DFND   410,274 0 7,568
APPLIED MATERIALS INC COM 038222105   397 3,230 SH   DFND   3,230 0 0
AT&T INC. COM 00206r102   9,031 469,166 SH   DFND   451,817 0 17,350
AVERY-DENNISON COM 053611109   233 1,300 SH   DFND   1,300 0 0
BANK OF AMERICA CORP COM 060505104   305 10,648 SH   DFND   10,648 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702   5,295 17,150 SH   DFND   17,069 0 81
BIOCRYST PHARMACEUTICALS COM 09058v103   417 50,000 SH   DFND   50,000 0 0
BIOSIGNIA INC COM 090998345   0 130,000 SH   DFND   130,000 0 0
BLACK STONE MINERALS LP COM 09225m101   314 20,000 SH   DFND   20,000 0 0
BLACKROCK INC COM COM 09247X101   23,350 34,897 SH   DFND   34,257 0 640
BOOKING HOLDINGS INC COM 09857l108   369 139 SH   DFND   139 0 0
BRISTOLMYERS SQUIBB COM 110122108   720 10,391 SH   DFND   9,522 0 869
CAPITAL ONE FINANCIAL COM 14040h105   416 4,324 SH   DFND   4,324 0 0
CATERPILLAR INC COM 149123101   1,602 7,000 SH   DFND   7,000 0 0
CDW CORP COM USD0.01 COM 12514g108   258 1,326 SH   DFND   1,326 0 0
CHEVRON CORPORATION COM 166764100   15,267 93,571 SH   DFND   92,146 0 1,425
CISCO SYS INC COM COM 17275R102   13,028 249,230 SH   DFND   241,729 0 7,501
CLEVELAND-CLIFFS INC COM 185899101   367 20,000 SH   DFND   20,000 0 0
CME GROUP INC COM COM 12572Q105   33,822 176,595 SH   DFND   173,584 0 3,011
COCA COLA COMPANY COM 191216100   17,970 289,702 SH   DFND   284,098 0 5,604
COMCAST CORP NEW CL A COM 20030n101   264 6,954 SH   DFND   6,954 0 0
COMMONWEALTH BANKSHARES INC (D COM 202736104   0 11,761 SH   DFND   11,761 0 0
COSTCO WHOLESALE COM 22160k105   994 2,000 SH   DFND   2,000 0 0
CUMMINS INC COM 231021106   9,024 37,777 SH   DFND   36,511 0 1,266
CURIS, INC. COM 231269200   61 102,550 SH   DFND   102,550 0 0
DANAHER CORP COM COM 235851102   17,657 70,054 SH   DFND   69,344 0 710
DISNEY WALT CO COM 254687106   29,255 292,166 SH   DFND   287,113 0 5,053
DOLLAR GENERAL CORP COM 256677105   13,516 64,220 SH   DFND   63,670 0 550
DOLLAR TREE STORES INC COM 256746108   220 1,533 SH   DFND   1,533 0 0
DOMINION RES INC VA NEW COM 25746u109   393 7,036 SH   DFND   6,285 0 750
DOW INC COM 260557103   474 8,651 SH   DFND   8,651 0 0
DRAFTKINGS, NEW CL A COM 26142v105   387 20,000 SH   DFND   20,000 0 0
DUKE ENERGY CORPORATION NEW COM 26441c204   1,880 19,493 SH   DFND   19,108 0 385
DUPONT DE NEMOURS INC. COM 26614n102   437 6,085 SH   DFND   6,085 0 0
ENBRIDGE INC COM 29250n105   285 7,465 SH   DFND   7,465 0 0
EXXON MOBIL CORP COM COM 30231G102   41,834 381,493 SH   DFND   374,982 0 6,511
FERGUSON PLC COM g3421j106   284 2,125 SH   DFND   2,125 0 0
FIBROGEN INC COM 31572q808   187 10,000 SH   DFND   10,000 0 0
FIRST HORIZON NATIONAL CORP COM 320517105   282 15,883 SH   DFND   15,883 0 0
FIVE BELOW COM 33829m101   893 4,336 SH   DFND   4,336 0 0
FNB CORP PA COM 302520101   6,216 535,900 SH   DFND   535,900 0 0
FORTUNE BRANDS INNOVATIONS INC COM 34964c106   319 5,433 SH   DFND   5,433 0 0
G1 THERAPEUTICS INC COM 3621lq109   89 33,160 SH   DFND   33,160 0 0
GENERAL DYNAMICS CRP COM 369550108   1,335 5,850 SH   DFND   5,850 0 0
GENERAL MILLS INC COM 370334104   4,818 56,372 SH   DFND   53,227 0 3,145
GILEAD SCIENCES INC COM COM 375558103   628 7,573 SH   DFND   7,573 0 0
GOLDMAN SACHS GROUP INC COM 38141g104   314 960 SH   DFND   960 0 0
HERSHEY FOODS COM 427866108   924 3,630 SH   DFND   3,630 0 0
HOME DEPOT INC COM COM 437076102   589 1,997 SH   DFND   1,997 0 0
HONEYWELL INTERNATIONAL INC CO COM 438516106   1,716 8,979 SH   DFND   8,979 0 0
IDEX CORPORATION COM 45167r104   5,574 24,125 SH   DFND   24,125 0 0
IDEXX LABORATORIES COM 45168d104   21,673 43,339 SH   DFND   42,999 0 340
ILLINOIS TOOL WORKS COM 452308109   1,027 4,220 SH   DFND   4,220 0 0
INFLARX NV COM n44821101   146 75,100 SH   DFND   75,100 0 0
INTEL CORP COM 458140100   524 16,026 SH   DFND   16,026 0 0
INTL BUSINESS MACHINES COM 459200101   9,494 72,422 SH   DFND   68,787 0 3,635
INTRA CELLULAR THERAPIES INC COM 46116x101   750 13,858 SH   DFND   13,833 0 25
ISHARES COMEX GOLD TR COM 464285204   228 6,090 SH   DFND   6,090 0 0
ISHARES TR DOW JONES SEL DIVID COM 464287168   1,875 16,000 SH   DFND   16,000 0 0
JOHNSON & JOHNSON COM 478160104   12,341 79,617 SH   DFND   77,292 0 2,325
JPMORGAN CHASE & CO COM 46625h100   21,557 165,428 SH   DFND   162,401 0 3,027
KIMBERLY CLARK CORP COM 494368103   201 1,500 SH   DFND   1,500 0 0
KKR & CO INC COM 48251w104   913 17,375 SH   DFND   17,375 0 0
KROGER CO COM 501044101   365 7,400 SH   DFND   7,400 0 0
LABORATORY CRP OF AMER HLDGS COM 50540r409   904 3,939 SH   DFND   3,939 0 0
LAUDER ESTEE COS INC CL A COM 518439104   19,238 78,057 SH   DFND   77,388 0 669
LILLY ELI & CO COM 532457108   310 902 SH   DFND   700 0 202
LINDE PLC NEW COM g54950103   21,865 61,515 SH   DFND   60,353 0 1,162
LOCKHEED MARTIN CORP COM 539830109   15,189 32,131 SH   DFND   31,536 0 595
LOWE'S COS COM 548661107   10,535 52,681 SH   DFND   27,546 0 25,135
MACQUARIE GROUP LTD COM 032870945   200 1,700 SH   DFND   1,700 0 0
MARRIOTT INTL NEW COM 571903202   12,825 77,241 SH   DFND   76,511 0 730
MARTIN MARIETTA MATERIALS INC COM 573284106   238 670 SH   DFND   670 0 0
MASCO CORP COM 574599106   232 4,669 SH   DFND   4,669 0 0
MC DONALDS CORP COM 580135101   11,557 41,332 SH   DFND   39,755 0 1,577
MEDTRONIC, PLC COM g5960l103   3,429 42,537 SH   DFND   40,247 0 2,290
MERCK & CO INC NEW COM 58933y105   1,428 13,425 SH   DFND   13,425 0 0
META PLATFORMS INC. CL A COM 30303m102   21,233 100,183 SH   DFND   99,358 0 825
MICRONTECHNOLOGY COM 595112103   333 5,522 SH   DFND   5,522 0 0
MICROSOFT CORP COM 594918104   64,162 222,553 SH   DFND   219,222 0 3,331
MONDELEZ INTL INC COM COM 609207105   15,816 226,857 SH   DFND   224,500 0 2,357
NEKTAR THERAPEUTICS COM 640268108   11 15,500 SH   DFND   15,500 0 0
NEXTERA ENERGY INC COM 65339f101   895 11,611 SH   DFND   11,209 0 402
NIKE INC CL B COM 654106103   15,744 128,372 SH   DFND   127,142 0 1,230
NORFOLK SOUTHERN CORP COM 655844108   2,928 13,810 SH   DFND   13,810 0 0
NORTHERN TRUST CORP COM 665859104   218 2,475 SH   DFND   2,475 0 0
NORTHROP GRUMMAN CORP COM 666807102   360 780 SH   DFND   780 0 0
NVIDIA CORP COM 67066g104   36,926 132,939 SH   DFND   131,737 0 1,202
NXP SEMICONDUCTORS NV COM n6596x109   10,452 56,051 SH   DFND   55,581 0 470
OMNICOM CORP. COM 681919106   219 2,320 SH   DFND   2,320 0 0
ORACLE CORP COM COM 68389X105   3,457 37,201 SH   DFND   36,902 0 299
PACCAR INC COM 693718108   202 2,763 SH   DFND   2,763 0 0
PAYCHEX INC COM 704326107   1,133 9,884 SH   DFND   9,316 0 568
PAYPAL HOLDINGS INC COM 70450y103   19,900 262,053 SH   DFND   259,909 0 2,144
PEPSICO INCORPORATED COM 713448108   1,033 5,669 SH   DFND   5,669 0 0
PFIZER INC COM 717081103   1,335 32,724 SH   DFND   29,981 0 2,743
PHILIP MORRIS INTL INC COM 718172109   810 8,330 SH   DFND   8,330 0 0
PNC BK CORP COM COM 693475105   216 1,700 SH   DFND   1,700 0 0
PROCTER & GAMBLE COM 742718109   9,513 63,976 SH   DFND   62,457 0 1,519
PROQR THERAPEUTICS N.V. COM n71542109   320 150,000 SH   DFND   150,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   281 12,220 SH   DFND   12,000 0 220
QUALCOMM INC COM COM 747525103   608 4,764 SH   DFND   4,764 0 0
RAYONIER INC COM COM 754907103   249 7,500 SH   DFND   7,500 0 0
RAYTHEON TECHNOLOGIES CORP COM COM 75513e101   26,833 274,005 SH   DFND   269,499 0 4,506
ROCKWELL INTERNATIONAL COM 773903109   13,508 46,032 SH   DFND   45,588 0 444
ROYAL BANK OF CANADA COM 780087102   1,186 12,409 SH   DFND   12,409 0 0
SABINE ROYALTY TRUST UBI COM 785688102   724 10,081 SH   DFND   10,081 0 0
SALESFORCE INC COM 79466l302   21,965 109,946 SH   DFND   109,031 0 915
SAPAG SPON ADR COM 803054204   241 1,901 SH   DFND   1,901 0 0
SAVI MEDIA GROUP INC (NO VALUE COM 80517r207   0 294,999 SH   DFND   294,999 0 0
SCHWAB (CHARLES) CORP COM 808513105   1,018 19,432 SH   DFND   18,927 0 505
SELECT SECTOR SPDR AMEX UTILIT COM 81369y886   6,687 98,794 SH   DFND   95,549 0 3,245
SHERWIN WILLIAMS CO COM 824348106   305 1,356 SH   DFND   1,356 0 0
SONY GROUP CORP COM 835699307   327 3,612 SH   DFND   3,612 0 0
SOUTHERN CO COM 842587107   686 9,863 SH   DFND   9,863 0 0
STARBUCKS CORP COM 855244109   26,481 254,311 SH   DFND   249,731 0 4,580
STRYKER CORP COM 863667101   908 3,180 SH   DFND   3,180 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108   725 20,000 SH   DFND   20,000 0 0
TARGET CORPORATION COM 87612e106   708 4,272 SH   DFND   4,272 0 0
TEXAS INSTRUMENTS COM 882508104   9,093 48,883 SH   DFND   47,139 0 1,744
THERMO FISHER CORP COM COM 883556102   25,042 43,448 SH   DFND   43,111 0 337
TJX COMPANIES COM 872540109   22,836 291,430 SH   DFND   285,720 0 5,710
TRUIST FINANCIAL CORP COM 89832q109   681 19,969 SH   DFND   19,969 0 0
UNILEVER PLC-SPONSORED ADR COM 904767704   203 3,901 SH   DFND   3,901 0 0
UNITED HEALTHCARE CORP COM 91324p102   862 1,824 SH   DFND   1,824 0 0
UNITED PARCEL SERVICE - CL B COM 911312106   17,215 88,742 SH   DFND   86,602 0 2,140
VERIZON COMMUNICATIONS COM 92343v104   1,292 33,223 SH   DFND   33,223 0 0
VIBE RECORDS INC NEW COM (DELI COM 925563108   0 11,000 SH   DFND   11,000 0 0
VISA INC CL A COM 92826c839   368 1,634 SH   DFND   1,634 0 0
WALMART INC. COM 931142103   9,093 61,670 SH   DFND   59,632 0 2,039
WASTE MANAGEMENT INC DEL COM 94106l109   3,172 19,443 SH   DFND   19,403 0 40
WELLS FARGO & CO NEW COM 949746101   1,584 42,383 SH   DFND   42,383 0 0
ZOETIS INC COM 98978v103   15,920 95,650 SH   DFND   94,842 0 808
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772   453 10,000 SH   DFND   10,000 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907   0 45,000 SH   DFND   45,000 0 0