The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 18,504 104,174 SH   DFND   101,459 0 2,715
ABBOTT LABORATORIES COM 002824100 477 3,390 SH   DFND   3,189 0 201
ABBVIE INC COM COM 00287Y109 45,222 333,991 SH   DFND   328,512 0 5,478
ACCENTURE PLC COM g1151c101 23,834 57,493 SH   DFND   56,433 0 1,060
ACTIVISION BLIZZARD INC COM 00507v109 15,637 235,030 SH   DFND   232,643 0 2,387
ADVANCE AUTO PARTS INC COM 00751y106 15,895 66,260 SH   DFND   65,586 0 674
AEGLEA BIOTHERAPEUTICS INC COM 00773j103 503 105,800 SH   DFND   105,300 0 500
AEGON NV - AMER REG SHS COM 007924103 226 45,710 SH   DFND   45,710 0 0
AFLAC INC COM COM 001055102 2,710 46,413 SH   DFND   45,998 0 415
AGILENT TECH INC COM 00846u101 343 2,151 SH   DFND   2,151 0 0
ALPHABET INC CAP STK CL A COM 02079k305 4,937 1,704 SH   DFND   1,704 0 0
ALPHABET INC CAP STK CL C COM 02079k107 49,481 17,100 SH   DFND   16,895 0 205
ALTRIA GROUP INC COM 02209s103 916 19,319 SH   DFND   19,319 0 0
AMAZON.COM INC COM 023135106 48,508 14,548 SH   DFND   14,352 0 196
AMER ELEC PWR INC COM COM 025537101 659 7,407 SH   DFND   7,390 0 17
AMERICAN EXPRESS CO COM COM 025816109 22,804 139,387 SH   DFND   137,385 0 2,002
AMGEN INC COM COM 031162100 1,209 5,375 SH   DFND   5,375 0 0
APPLE INC COM COM 037833100 92,426 520,507 SH   DFND   512,027 0 8,479
APPLIED MATERIALS INC COM 038222105 610 3,875 SH   DFND   3,875 0 0
AT&T INC. COM 00206r102 1,795 72,956 SH   DFND   61,566 0 11,390
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   DFND   95,714 0 0
BANK OF AMERICA CORP COM 060505104 491 11,035 SH   DFND   11,035 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 7,056 23,600 SH   DFND   23,445 0 155
BIOCRYST PHARMACEUTICALS COM 09058v103 693 50,000 SH   DFND   50,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   DFND   130,000 0 0
BLACK STONE MINERALS LP COM 09225m101 289 28,000 SH   DFND   28,000 0 0
BLACKROCK INC COM COM 09247X101 41,462 45,286 SH   DFND   44,556 0 730
BOOKING HOLDINGS INC COM 09857l108 259 108 SH   DFND   108 0 0
BP PLC COM 055622104 643 24,139 SH   DFND   24,139 0 0
BRISTOLMYERS SQUIBB COM 110122108 600 9,631 SH   DFND   8,762 0 869
CALITHERA BIOSCIENCES, INC. COM 13089p101 89 133,700 SH   DFND   131,700 0 2,000
CAPITAL ONE FINANCIAL COM 14040h105 659 4,540 SH   DFND   4,540 0 0
CATERPILLAR INC COM 149123101 1,344 6,500 SH   DFND   6,500 0 0
CHEVRON CORPORATION COM 166764100 2,709 23,081 SH   DFND   22,831 0 250
CISCO SYS INC COM COM 17275R102 27,387 432,179 SH   DFND   424,957 0 7,222
CME GROUP INC COM COM 12572Q105 39,795 174,189 SH   DFND   171,230 0 2,959
COCA COLA COMPANY COM 191216100 20,349 343,677 SH   DFND   338,120 0 5,557
COLGATE-PALMOLIVE CO COM 194162103 208 2,442 SH   DFND   2,442 0 0
COMCAST CORP NEW CL A COM 20030n101 760 15,108 SH   DFND   15,108 0 0
COMMONWEALTH BANKSHARES INC (D COM 202736104 0 11,761 SH   DFND   11,761 0 0
CONSTELLATION BRANDS INC CL A COM 21036p108 204 812 SH   DFND   812 0 0
COSTCO WHOLESALE COM 22160k105 1,150 2,025 SH   DFND   2,025 0 0
CUMMINS INC COM 231021106 7,418 34,005 SH   DFND   32,980 0 1,025
CURIS, INC. COM 231269200 250 52,550 SH   DFND   52,550 0 0
DANAHER CORP COM COM 235851102 28,652 87,084 SH   DFND   86,137 0 947
DISNEY WALT CO COM 254687106 19,207 124,002 SH   DFND   122,293 0 1,709
DOLLAR GENERAL CORP COM 256677105 20,850 88,411 SH   DFND   87,724 0 687
DOLLAR TREE STORES INC COM 256746108 238 1,696 SH   DFND   1,696 0 0
DOMINION RES INC VA NEW COM 25746u109 4,956 63,092 SH   DFND   59,107 0 3,984
DOW INC COM 260557103 474 8,351 SH   DFND   8,351 0 0
DRAFTKINGS CL A COM 26142r104 275 10,000 SH   DFND   10,000 0 0
DUKE ENERGY CORPORATION NEW COM 26441c204 1,921 18,311 SH   DFND   17,888 0 423
DUPONT DE NEMOURS INC. COM 26614n102 492 6,085 SH   DFND   6,085 0 0
ECOLAB INC COM COM 278865100 19,556 83,363 SH   DFND   82,397 0 966
ENBRIDGE INC COM 29250n105 485 12,398 SH   DFND   12,364 0 34
EXELON CORPORATION COM 30161n101 234 4,055 SH   DFND   4,000 0 55
EXXON MOBIL CORP COM COM 30231G102 30,065 491,341 SH   DFND   483,861 0 7,480
FASTENAL CO COM 311900104 224 3,500 SH   DFND   3,500 0 0
FEDEXCORP COM 31428x106 280 1,083 SH   DFND   1,083 0 0
FIBROGEN INC COM 31572q808 296 21,000 SH   DFND   21,000 0 0
FIRST BANCORP NORTH CAROLINA COM 318910106 505 11,055 SH   DFND   11,055 0 0
FIRST HORIZON NATIONAL CORP COM 320517105 259 15,883 SH   DFND   15,883 0 0
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 698 6,533 SH   DFND   6,533 0 0
G1 THERAPEUTICS INC COM 3621lq109 236 23,160 SH   DFND   23,160 0 0
GENERAL DYNAMICS CRP COM 369550108 1,220 5,850 SH   DFND   5,850 0 0
GENERAL MILLS INC COM 370334104 2,869 42,575 SH   DFND   39,575 0 3,000
GENUINE PARTS COM 372460105 8,316 59,316 SH   DFND   57,893 0 1,423
GILEAD SCIENCES INC COM COM 375558103 589 8,113 SH   DFND   8,113 0 0
GOLDMAN SACHS BDC INC COM 38147u107 760 39,687 SH   DFND   39,687 0 0
GOLDMAN SACHS GROUP INC COM 38141g104 625 1,635 SH   DFND   1,635 0 0
HOME DEPOT INC COM COM 437076102 15,046 36,255 SH   DFND   35,836 0 419
HONEYWELL INTERNATIONAL INC CO COM 438516106 12,750 61,149 SH   DFND   60,599 0 550
IDEX CORPORATION COM 45167r104 5,701 24,125 SH   DFND   24,125 0 0
IDEXX LABORATORIES COM 45168d104 15,356 23,321 SH   DFND   23,007 0 314
ILLINOIS TOOL WORKS COM 452308109 1,041 4,220 SH   DFND   4,220 0 0
INFLARX NV COM n44821101 357 75,100 SH   DFND   75,100 0 0
INTEL CORP COM 458140100 882 17,119 SH   DFND   17,119 0 0
INTL BUSINESS MACHINES COM 459200101 1,125 8,414 SH   DFND   7,567 0 847
INTRA CELLULAR THERAPIES INC COM 46116x101 1,879 35,908 SH   DFND   35,808 0 100
INVESTORS TITLE COM 461804106 246 1,250 SH   DFND   1,250 0 0
ISHARES COMEX GOLD TR COM 464285204 212 6,090 SH   DFND   6,090 0 0
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,961 16,000 SH   DFND   16,000 0 0
JOHNSON & JOHNSON COM 478160104 12,723 74,373 SH   DFND   72,309 0 2,064
JPMORGAN CHASE & CO COM 46625h100 35,757 225,809 SH   DFND   222,589 0 3,220
KIMBERLY CLARK CORP COM 494368103 222 1,555 SH   DFND   1,555 0 0
KINDER MORGAN INC COM 49456b101 775 48,860 SH   DFND   48,860 0 0
KKR & CO INC COM 48251w104 1,294 17,375 SH   DFND   17,375 0 0
KROGER CO COM 501044101 402 8,875 SH   DFND   8,875 0 0
LABORATORY CRP OF AMER HLDGS COM 50540r409 22,481 71,547 SH   DFND   70,888 0 659
LAM RESEARCH CORP COM 512807108 241 335 SH   DFND   335 0 0
LAUDER ESTEE COS INC CL A COM 518439104 19,913 53,791 SH   DFND   53,193 0 598
LINCOLN NATIONAL CORP COM 534187109 209 3,067 SH   DFND   3,067 0 0
LINDE PLC COM COM g5494j103 23,886 68,948 SH   DFND   67,912 0 1,036
LOWE'S COS COM 548661107 18,264 70,660 SH   DFND   70,660 0 0
M & T BANK CORP COM 55261f104 226 1,470 SH   DFND   1,470 0 0
MACQUARIE GROUP LTD COM 032870945 254 1,700 SH   DFND   1,700 0 0
MARRIOTT INTL NEW COM 571903202 15,779 95,491 SH   DFND   94,533 0 958
MARTIN MARIETTA MATERIALS INC COM 573284106 590 1,340 SH   DFND   1,340 0 0
MASCO CORP COM 574599106 407 5,796 SH   DFND   5,796 0 0
MC DONALDS CORP COM 580135101 10,073 37,578 SH   DFND   36,307 0 1,271
MEDTRONIC, PLC COM g5960l103 350 3,383 SH   DFND   3,383 0 0
MERCK & CO INC NEW COM 58933y105 1,077 14,056 SH   DFND   14,056 0 0
META PLATFORMS INC. CL A COM 30303m102 29,975 89,118 SH   DFND   88,321 0 797
MICRONTECHNOLOGY COM 595112103 465 4,989 SH   DFND   4,989 0 0
MICROSOFT CORP COM 594918104 77,893 231,605 SH   DFND   228,318 0 3,287
MONDELEZ INTL INC COM COM 609207105 13,401 202,096 SH   DFND   199,814 0 2,282
NEKTAR THERAPEUTICS COM 640268108 209 15,500 SH   DFND   15,500 0 0
NESTLES A SPONSORED ADR REPSTG COM 641069406 321 2,287 SH   DFND   2,287 0 0
NEXTERA ENERGY INC COM 65339f101 1,598 17,119 SH   DFND   16,717 0 402
NIKE INC CL B COM 654106103 23,037 138,217 SH   DFND   136,916 0 1,301
NORFOLK SOUTHERN CORP COM 655844108 4,164 13,987 SH   DFND   13,987 0 0
NORTHERN TRUST CORP COM 665859104 203 1,694 SH   DFND   1,694 0 0
NORTHROP GRUMMAN CORP COM 666807102 263 680 SH   DFND   680 0 0
NOVELION THERAPEUT ESCROW COM 670esc029 0 26,000 SH   DFND   26,000 0 0
NVIDIA CORP COM 67066g104 38,499 130,901 SH   DFND   129,626 0 1,275
NXP SEMICONDUCTORS NV COM n6596x109 10,999 48,286 SH   DFND   47,799 0 487
ORACLE CORP COM COM 68389X105 2,592 29,721 SH   DFND   29,487 0 234
PACCAR INC COM 693718108 212 2,407 SH   DFND   2,407 0 0
PAYCHEX INC COM 704326107 15,363 112,549 SH   DFND   108,937 0 3,611
PAYPAL HOLDINGS INC COM 70450y103 36,267 192,314 SH   DFND   190,372 0 1,942
PEPSICO INCORPORATED COM 713448108 1,087 6,258 SH   DFND   6,258 0 0
PFIZER INC COM 717081103 6,812 115,363 SH   DFND   108,515 0 6,848
PHILIP MORRIS INTL INC COM 718172109 878 9,238 SH   DFND   9,238 0 0
PNC BK CORP COM COM 693475105 341 1,700 SH   DFND   1,700 0 0
PPG INDUSTRIES INC. COM 693506107 208 1,208 SH   DFND   1,208 0 0
PROCTER & GAMBLE COM 742718109 10,423 63,716 SH   DFND   62,197 0 1,519
PROQR THERAPEUTICS N.V. COM n71542109 881 110,000 SH   DFND   110,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 760 22,220 SH   DFND   22,000 0 220
QUALCOMM INC COM COM 747525103 1,038 5,674 SH   DFND   5,674 0 0
QUEST DIAGNOSTICS INC COM 74834L100 282 1,631 SH   DFND   1,631 0 0
RAYONIER INC COM COM 754907103 303 7,500 SH   DFND   7,500 0 0
RAYTHEON TECHNOLOGIES CORP COM COM 75513e101 2,173 25,250 SH   DFND   24,930 0 320
ROCKWELL INTERNATIONAL COM 773903109 846 2,424 SH   DFND   2,367 0 57
ROYAL BANK OF CANADA COM 780087102 1,317 12,409 SH   DFND   12,409 0 0
SABINE ROYALTY TRUST UBI COM 785688102 420 10,081 SH   DFND   10,081 0 0
SALESFORCE.COM INC COM 79466l302 22,176 87,261 SH   DFND   86,464 0 797
SANGAMO BIOSCIENCES INC COM 800677106 422 56,330 SH   DFND   55,500 0 830
SAVI MEDIA GROUP INC (NO VALUE COM 80517r207 0 294,999 SH   DFND   294,999 0 0
SCHWAB (CHARLES) CORP COM 808513105 1,621 19,277 SH   DFND   18,772 0 505
SCOTTS MIRACLE-GRO CO COM 810186106 407 2,528 SH   DFND   2,528 0 0
SHERWIN WILLIAMS CO COM 824348106 478 1,356 SH   DFND   1,356 0 0
SMITH & NEPHEW PLC SPONS ADR N COM 83175M205 242 7,004 SH   DFND   7,004 0 0
SONY CORP ADR NEW COM 835699307 370 2,924 SH   DFND   2,924 0 0
SOUTHERN CO COM 842587107 686 10,006 SH   DFND   9,955 0 51
STANDARD & POOR'S DEP RCPTS COM 78462f103 6,750 14,212 SH   DFND   14,212 0 0
STRYKER CORP COM 863667101 884 3,305 SH   DFND   3,305 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 617 21,145 SH   DFND   21,000 0 145
SYSCO CORP COM 871829107 1,202 15,302 SH   DFND   15,302 0 0
TARGET CORPORATION COM 87612e106 1,049 4,533 SH   DFND   4,533 0 0
TESLA MOTORS INC COM 88160r101 18,671 17,668 SH   DFND   17,528 0 140
TEXAS INSTRUMENTS COM 882508104 9,268 49,177 SH   DFND   47,726 0 1,451
THERMO FISHER CORP COM COM 883556102 20,067 30,074 SH   DFND   29,738 0 336
TRUIST FINANCIAL CORP COM 89832q109 1,134 19,371 SH   DFND   19,371 0 0
TYME TECHNOLOGIES INC NEW COM 90238j103 24 40,000 SH   DFND   40,000 0 0
UB BANCORP COM COM 903450104 5,889 333,677 SH   DFND   333,677 0 0
UNILEVER PLC-SPONSORED ADR COM 904767704 288 5,356 SH   DFND   5,356 0 0
UNIONPACIFIC CORP COM 907818108 255 1,014 SH   DFND   1,014 0 0
UNITED HEALTHCARE CORP COM 91324p102 1,234 2,458 SH   DFND   2,458 0 0
UNITED PARCEL SERVICE - CL B COM 911312106 20,974 97,853 SH   DFND   95,936 0 1,916
V F CORP COM 918204108 8,461 115,555 SH   DFND   112,302 0 3,253
VERIZON COMMUNICATIONS COM 92343v104 6,075 116,919 SH   DFND   115,879 0 1,040
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   DFND   11,000 0 0
WALMART INC. COM 931142103 9,858 68,130 SH   DFND   66,513 0 1,617
WASTE MANAGEMENT INC DEL COM 94106l109 13,165 78,877 SH   DFND   76,764 0 2,113
WELLS FARGO & CO NEW COM 949746101 2,039 42,505 SH   DFND   42,505 0 0
WOLFSPEED INC COM 977852102 201 1,800 SH   DFND   1,800 0 0
ZOETIS INC COM 98978v103 17,346 71,081 SH   DFND   70,302 0 779
INVESCO S&P 500 EQUAL WEIGHT E ADR 46137v357 271 1,667 SH   DFND   1,667 0 0
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 666 10,000 SH   DFND   10,000 0 0
CALL (FCX) FREEPORT-MCMORAN IN CALL 4354519mm 217 100 SH   DFND   100 0 0
CALL (NEU) NUCOR CORP JUL 15, CALL 5628179rn 365 100 SH   DFND   100 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 45,000 SH   DFND   45,000 0 0