The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 707 3,357 SH   SOLE   3,357 0 0
ABBOTT LABORATORIES COM 002824100 339 4,622 SH   SOLE   4,622 0 0
ABBVIE INC COM COM 00287Y109 16,522 174,683 SH   SOLE   168,058 0 6,625
ABEONA THERAPEUTICS INC COM 00289y107 141 11,000 SH   SOLE   11,000 0 0
ACCENTURE PLC COM g1151c101 235 1,379 SH   SOLE   329 0 1,050
ACTIVISION BLIZZARD INC COM 00507v109 7,290 87,633 SH   SOLE   86,196 0 1,437
ADVAXIS INC COM 007624208 179 190,800 SH   SOLE   100,800 0 90,000
AFLAC INC COM COM 001055102 3,784 80,394 SH   SOLE   74,639 0 5,755
ALPHABET INC CAP STK CL A COM 02079k305 1,624 1,345 SH   SOLE   1,145 0 200
ALPHABET INC CAP STK CL C COM 02079k107 20,488 17,167 SH   SOLE   16,571 0 596
ALTRIA GROUP INC COM 02209s103 266 4,410 SH   SOLE   4,410 0 0
AMAZON.COM INC COM 023135106 21,202 10,585 SH   SOLE   10,245 0 340
AMER ELEC PWR INC COM COM 025537101 374 5,271 SH   SOLE   5,271 0 0
AMERICAN EXPRESS CO COM COM 025816109 8,626 81,002 SH   SOLE   80,157 0 845
AMGEN INC COM COM 031162100 560 2,701 SH   SOLE   1,701 0 1,000
APPLE INC COM COM 037833100 35,629 157,832 SH   SOLE   150,890 0 6,942
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,083 32,244 SH   SOLE   32,244 0 0
AUTOMATIC DATA PROCESSING COM 053015103 233 1,544 SH   SOLE   1,544 0 0
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 676 22,958 SH   SOLE   22,958 0 0
BB & T COM 054937107 1,213 24,985 SH   SOLE   23,883 0 1,102
BELLLICUM PHARMACEUTICALS INC COM 079481107 309 50,115 SH   SOLE   5,115 0 45,000
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 12,879 60,151 SH   SOLE   55,988 0 4,163
BIOCRYST PHARMACEUTICALS COM 09058v103 328 43,000 SH   SOLE   43,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BLACK STONE MINERALS LP COM 09225m101 510 28,000 SH   SOLE   28,000 0 0
BLACKROCK INC COM COM 09247X101 10,604 22,498 SH   SOLE   21,595 0 903
BOEING CO COM 097023105 2,336 6,282 SH   SOLE   6,282 0 0
BRISTOLMYERS SQUIBB COM 110122108 16,723 269,377 SH   SOLE   261,342 0 8,035
CALITHERA BIOSCIENCES, INC. COM 13089p101 428 81,580 SH   SOLE   11,580 0 70,000
CAPITAL ONE FINANCIAL COM 14040h105 395 4,165 SH   SOLE   4,165 0 0
CATERPILLAR INC COM 149123101 11,780 77,248 SH   SOLE   74,503 0 2,745
CHEVRON CORPORATION COM 166764100 10,103 82,623 SH   SOLE   78,123 0 4,500
CISCO SYS INC COM COM 17275R102 21,563 443,229 SH   SOLE   431,674 0 11,555
CME GROUP INC COM COM 12572Q105 28,435 167,057 SH   SOLE   161,222 0 5,835
COCA COLA COMPANY COM 191216100 9,582 207,440 SH   SOLE   196,155 0 11,285
COMCASTCORP NEW CL A COM 20030n101 304 8,581 SH   SOLE   2,681 0 5,900
COMMONWEALTH BANKSHARES INC (D COM 202736104 0 11,761 SH   SOLE   11,761 0 0
CONOCOPHILLIPS COM 20825c104 500 6,455 SH   SOLE   6,455 0 0
CORE LABS COM N22717107 9,075 78,347 SH   SOLE   77,387 0 960
COSTCO WHOLESALE COM 22160k105 541 2,305 SH   SOLE   2,305 0 0
CVS CAREMARK CORP COM 126650100 9,094 115,520 SH   SOLE   109,890 0 5,630
DANAHER CORP COM COM 235851102 16,832 154,905 SH   SOLE   152,655 0 2,250
DISNEY WALT CO COM 254687106 11,505 98,381 SH   SOLE   94,076 0 4,305
DOLLAR GENERAL CORP COM 256677105 10,831 99,091 SH   SOLE   95,456 0 3,635
DOMINION RES INC VA NEW COM 25746u109 8,451 120,249 SH   SOLE   115,289 0 4,960
DOWDUPONT INC COM 26078j100 11,451 178,063 SH   SOLE   172,208 0 5,855
DUKE ENERGY CORPORATION NEW COM 26441c204 1,166 14,566 SH   SOLE   13,533 0 1,033
EBAY INC COM COM 278642103 230 6,965 SH   SOLE   2,015 0 4,950
ECOLAB INC COM COM 278865100 209 1,332 SH   SOLE   1,332 0 0
ENBRIDGE INC COM 29250n105 548 16,977 SH   SOLE   12,240 0 4,737
ENDOCYTE INC COM 29269A102 398 22,425 SH   SOLE   2,425 0 20,000
EOG RESOURCES INC COM 26875p101 12,972 101,684 SH   SOLE   100,189 0 1,495
EPIGENOMICS AG BERLIN COM d2552q171 26 10,000 SH   SOLE   10,000 0 0
EXXON MOBIL CORP COM COM 30231G102 4,133 48,617 SH   SOLE   44,879 0 3,738
FACEBOOK COM 30303m102 14,600 88,778 SH   SOLE   87,233 0 1,545
FEDEXCORP COM 31428x106 415 1,725 SH   SOLE   225 0 1,500
FIBROGEN INC COM 31572q808 608 10,000 SH   SOLE   0 0 10,000
FIRST BANCORP NORTH CAROLINA COM 318910106 411 10,144 SH   SOLE   10,144 0 0
FIVE PRIME THERAPEUTICS, INC. COM 33830x104 139 10,000 SH   SOLE   0 0 10,000
FORTIVE CORP COM COM 34959j108 7,298 86,670 SH   SOLE   85,139 0 1,531
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 3,831 73,166 SH   SOLE   73,021 0 145
GENERAL DYNAMICS CRP COM 369550108 1,250 6,107 SH   SOLE   4,367 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 765 67,743 SH   SOLE   59,043 0 8,700
GENERAL MOTORS COM 37045v100 468 13,887 SH   SOLE   13,887 0 0
GILEAD SCIENCES INC COM COM 375558103 9,034 117,008 SH   SOLE   113,803 0 3,205
GOLDMAN SACHS GROUP INC COM 38141g104 4,375 19,510 SH   SOLE   18,020 0 1,490
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HERSHEY FOODS COM 427866108 5,010 49,120 SH   SOLE   48,310 0 810
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 233 14,314 SH   SOLE   14,314 0 0
HOME DEPOT INC COM COM 437076102 7,842 37,856 SH   SOLE   37,226 0 630
HONEYWELL INTERNATIONAL INC CO COM 438516106 13,477 80,989 SH   SOLE   78,659 0 2,330
HP, INC. COM 40434l105 363 14,076 SH   SOLE   14,076 0 0
IDEXX LABORATORIES COM 45168d104 11,144 44,638 SH   SOLE   43,944 0 694
ILLINOIS TOOL WORKS COM 452308109 564 4,000 SH   SOLE   4,000 0 0
INCYTE GENOMICS INC COM 45337c102 276 4,000 SH   SOLE   4,000 0 0
INSMED INC COM 457669307 324 16,000 SH   SOLE   16,000 0 0
INTEL CORP COM 458140100 1,016 21,479 SH   SOLE   21,479 0 0
INTL BUSINESS MACHINES COM 459200101 7,024 46,455 SH   SOLE   44,515 0 1,940
INTRA CELLULAR THERAPIES INC COM 46116x101 1,173 54,060 SH   SOLE   4,060 0 50,000
IQVIA HLDGS INC COM 46266C105 259 2,000 SH   SOLE   200 0 1,800
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,787 17,915 SH   SOLE   17,915 0 0
JOHNSON & JOHNSON COM 478160104 11,200 81,063 SH   SOLE   76,508 0 4,555
JPMORGAN CHASE & CO COM 46625h100 18,510 164,034 SH   SOLE   156,057 0 7,977
KINDER MORGAN INC COM 49456b101 1,408 79,391 SH   SOLE   68,826 0 10,565
KKR & CO INC COM 48251w104 474 17,375 SH   SOLE   17,375 0 0
KRAFT HEINZ CO. COM 500754106 338 6,137 SH   SOLE   5,987 0 150
LABORATORY CRP OF AMER HLDGS COM 50540r409 13,801 79,465 SH   SOLE   78,469 0 996
LAUDER ESTEE COS INC CL A COM 518439104 1,175 8,085 SH   SOLE   7,995 0 90
LINCOLN NATIONAL CORP COM 534187109 408 6,026 SH   SOLE   6,026 0 0
LOCKHEED MARTIN CORP COM 539830109 8,551 24,718 SH   SOLE   23,838 0 880
LOWE'S COS COM 548661107 580 5,050 SH   SOLE   5,050 0 0
MARRIOTT INTL NEW COM 571903202 8,402 63,637 SH   SOLE   62,732 0 905
MATTEL INC COM 577081102 236 15,000 SH   SOLE   15,000 0 0
MC DONALDS CORP COM 580135101 8,438 50,438 SH   SOLE   48,428 0 2,010
MELINTA THERAPEUTICS INC COM 58549G100 255 64,650 SH   SOLE   4,650 0 60,000
MERCK & CO INC NEW COM 58933y105 1,338 18,860 SH   SOLE   15,770 0 3,090
METLIFE INC COM 59156r108 7,000 149,822 SH   SOLE   144,347 0 5,475
MICROSOFT CORP COM 594918104 28,882 252,535 SH   SOLE   240,570 0 11,965
MONDELEZ INTL INC COM COM 609207105 10,824 251,945 SH   SOLE   248,500 0 3,445
NEKTAR THERAPEUTICS COM 640268108 3,536 58,000 SH   SOLE   58,000 0 0
NEXTERA ENERGY INC COM 65339f101 563 3,357 SH   SOLE   3,357 0 0
NIKE INC CL B COM 654106103 12,363 145,923 SH   SOLE   144,103 0 1,820
NORFOLK SOUTHERN CORP COM 655844108 2,615 14,485 SH   SOLE   14,485 0 0
NORTHROP GRUMMAN CORP COM 666807102 248 780 SH   SOLE   780 0 0
NOVELION THERAPEUTICS INC NEW COM 67001k202 77 26,000 SH   SOLE   20,000 0 6,000
ORACLE CORP COM COM 68389X105 2,646 51,325 SH   SOLE   42,545 0 8,780
PAYCHEX INC COM 704326107 8,299 112,682 SH   SOLE   105,617 0 7,065
PAYPAL HOLDINGS INC COM 70450y103 18,147 206,586 SH   SOLE   200,846 0 5,740
PDL BIOPHARMA INC COM 69329y104 53 20,000 SH   SOLE   20,000 0 0
PEPSICO INCORPORATED COM 713448108 1,081 9,669 SH   SOLE   5,934 0 3,735
PFIZER INC COM 717081103 1,572 35,676 SH   SOLE   35,676 0 0
PHILIP MORRIS INTL INC COM 718172109 520 6,376 SH   SOLE   6,376 0 0
PHILLIPS 66 COM 718546104 381 3,377 SH   SOLE   3,377 0 0
PINNACLE FINANCIAL PARTNERS IN COM 72346q104 1,107 18,409 SH   SOLE   18,409 0 0
PNC BK CORP COM COM 693475105 252 1,848 SH   SOLE   248 0 1,600
PROCTER & GAMBLE COM 742718109 1,709 20,536 SH   SOLE   17,616 0 2,920
PROQR THERAPEUTICS N.V. COM n71542109 1,161 60,000 SH   SOLE   0 0 60,000
PROTAGONIST THERAPEUTICS INC COM 74366E102 278 27,000 SH   SOLE   7,000 0 20,000
PUMA BIOTECHNOLOGY INC COM 74587v107 459 10,000 SH   SOLE   0 0 10,000
QUALCOMM INC COM COM 747525103 585 8,115 SH   SOLE   8,115 0 0
RAYONIER INC COM COM 754907103 254 7,500 SH   SOLE   7,500 0 0
REPLIGEN CORP COM 759916109 555 10,000 SH   SOLE   10,000 0 0
RIGEL PHARMACEUTICALS COM 766559603 66 20,500 SH   SOLE   20,500 0 0
ROYAL BANK OF CANADA COM 780087102 5,557 69,292 SH   SOLE   65,502 0 3,790
ROYAL DUTCH SHELL PLC SPON ADR COM 780259206 224 3,285 SH   SOLE   1,285 0 2,000
S&P GLOBAL INC COM 78409v104 286 1,466 SH   SOLE   1,466 0 0
SABINE ROYALTY TRUST UBI COM 785688102 844 20,000 SH   SOLE   20,000 0 0
SALESFORCE.COM INC COM 79466l302 259 1,627 SH   SOLE   1,627 0 0
SANGAMO BIOSCIENCES INC COM 800677106 693 40,900 SH   SOLE   10,900 0 30,000
SCANA CORP COM 80589m102 310 7,980 SH   SOLE   7,980 0 0
SCHLUMBERGER LTD COM COM 806857108 7,689 126,209 SH   SOLE   119,504 0 6,705
SCHWAB (CHARLES) CORP COM 808513105 341 6,945 SH   SOLE   6,945 0 0
SELECT BANCORP INC NEW COM 81617l108 593 47,830 SH   SOLE   47,830 0 0
SOUTHERN CO COM 842587107 543 12,444 SH   SOLE   12,044 0 400
SQUARE INC COM COM 852234103 9,017 91,071 SH   SOLE   89,686 0 1,385
STANDARD & POOR'S DEP RCPTS COM 78462f103 3,926 13,504 SH   SOLE   12,504 0 1,000
STRYKER CORP COM 863667101 498 2,800 SH   SOLE   800 0 2,000
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,470 29,200 SH   SOLE   29,200 0 0
TAPESTRY INC COM 876030107 8,903 177,101 SH   SOLE   166,661 0 10,440
TARGET CORPORATION COM 87612e106 537 6,090 SH   SOLE   6,090 0 0
TEXTRON INC COM 883203101 256 3,585 SH   SOLE   3,585 0 0
THERMO FISHER CORP COM COM 883556102 5,523 22,629 SH   SOLE   22,004 0 625
TJX COMPANIES COM 872540109 215 1,920 SH   SOLE   0 0 1,920
TWENTY FIRST CENTURY FOX INC C COM 90130a200 208 4,550 SH   SOLE   0 0 4,550
TYME TECHNOLOGIES INC NEW COM 90238j103 114 41,000 SH   SOLE   1,000 0 40,000
ULTA SALON, COS & FRAG INC COM 90384s303 2,174 7,705 SH   SOLE   7,385 0 320
UNDER ARMOUR INC CL C COM 904311206 4,892 251,399 SH   SOLE   246,664 0 4,735
UNION BANK COM 90520v103 5,187 323,164 SH   SOLE   323,164 0 0
UNITED HEALTHCARE CORP COM 91324p102 297 1,117 SH   SOLE   237 0 880
UNITED INSURANCE HOLDINGS CORP COM 910710102 1,427 63,750 SH   SOLE   63,750 0 0
UNITED PARCEL SERVICE - CL B COM 911312106 246 2,110 SH   SOLE   310 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 11,551 82,621 SH   SOLE   81,546 0 1,075
V F CORP COM 918204108 8,317 88,996 SH   SOLE   84,946 0 4,050
VERIZON COMMUNICATIONS COM 92343v104 9,444 176,890 SH   SOLE   170,272 0 6,618
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   SOLE   11,000 0 0
WALMART INC. COM 931142103 7,899 84,115 SH   SOLE   77,270 0 6,845
WASTE MANAGEMENT INC DEL COM 94106l109 9,163 101,403 SH   SOLE   96,818 0 4,585
WELLS FARGO & CO NEW COM 949746101 1,255 23,878 SH   SOLE   23,878 0 0
WILLIAMS CO INC COM 969457100 353 12,990 SH   SOLE   9,990 0 3,000
YUM BRANDS INC COM 988498101 8,195 90,149 SH   SOLE   88,949 0 1,200
ZOETIS INC COM 98978v103 369 4,026 SH   SOLE   4,026 0 0
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 377 10,000 SH   SOLE   10,000 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0
QLT INC WTS WT 746992171 0 230,000 SH   SOLE   200,000 0 30,000
QLT INC WTS WT 746992189 0 230,000 SH   SOLE   200,000 0 30,000