The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 533 2,707 SH   SOLE   2,707 0 0
ABBOTT LABORATORIES COM 002824100 232 3,807 SH   SOLE   3,807 0 0
ABBVIE INC COM COM 00287Y109 16,690 180,142 SH   SOLE   174,027 0 6,115
ABEONA THERAPEUTICS INC COM 00289y107 176 11,000 SH   SOLE   11,000 0 0
ACCENTURE PLC COM g1151c101 221 1,349 SH   SOLE   299 0 1,050
ADVAXIS INC COM 007624208 190 130,800 SH   SOLE   100,800 0 30,000
AFLAC INC COM COM 001055102 3,620 84,144 SH   SOLE   79,189 0 4,955
AIMMUNE THERAPEUTICS INC COM 00900t107 454 16,880 SH   SOLE   1,880 0 15,000
ALIBABA GROUP LTD SPR ADR COM 01609w102 717 3,867 SH   SOLE   3,867 0 0
ALPHABET INC CAP STK CL A COM 02079k305 2,086 1,847 SH   SOLE   1,647 0 200
ALPHABET INC CAP STK CL C COM 02079k107 18,473 16,558 SH   SOLE   16,177 0 381
ALTRIA GROUP INC COM 02209s103 276 4,860 SH   SOLE   4,860 0 0
AMAZON.COM INC COM 023135106 19,979 11,754 SH   SOLE   11,476 0 278
AMER ELEC PWR INC COM COM 025537101 391 5,652 SH   SOLE   5,652 0 0
AMERICAN EXPRESS CO COM COM 025816109 7,848 80,080 SH   SOLE   79,680 0 400
AMGEN INC COM COM 031162100 499 2,701 SH   SOLE   1,701 0 1,000
APPLE INC COM COM 037833100 30,735 166,034 SH   SOLE   159,482 0 6,552
ARALEZ PHARMACEUTICALS INC COM 03852x100 34 96,429 SH   SOLE   13,929 0 82,500
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,117 34,797 SH   SOLE   34,797 0 0
AUTOMATIC DATA PROCESSING COM 053015103 207 1,544 SH   SOLE   1,544 0 0
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 683 24,239 SH   SOLE   24,239 0 0
BB & T COM 054937107 821 16,281 SH   SOLE   15,179 0 1,102
BELLLICUM PHARMACEUTICALS INC COM 079481107 373 50,545 SH   SOLE   5,545 0 45,000
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 7,662 41,049 SH   SOLE   37,319 0 3,730
BIOCRYST PHARMACEUTICALS COM 09058v103 246 43,000 SH   SOLE   43,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BLACK STONE MINERALS LP COM 09225m101 518 28,000 SH   SOLE   28,000 0 0
BLACKROCK INC COM COM 09247X101 16,432 32,928 SH   SOLE   32,067 0 861
BOEING CO COM 097023105 2,309 6,882 SH   SOLE   6,882 0 0
BRISTOLMYERS SQUIBB COM 110122108 14,948 270,117 SH   SOLE   263,567 0 6,550
CALITHERA BIOSCIENCES, INC. COM 13089p101 408 81,580 SH   SOLE   11,580 0 70,000
CAPITAL ONE FINANCIAL COM 14040h105 368 4,000 SH   SOLE   4,000 0 0
CATERPILLAR INC COM 149123101 9,296 68,520 SH   SOLE   66,480 0 2,040
CELGENE COM 151020104 1,207 15,200 SH   SOLE   15,200 0 0
CHEVRON CORPORATION COM 166764100 10,301 81,474 SH   SOLE   77,839 0 3,635
CISCO SYS INC COM COM 17275R102 19,023 442,098 SH   SOLE   432,903 0 9,195
CME GROUP INC COM COM 12572Q105 27,564 168,154 SH   SOLE   163,169 0 4,985
COCA COLA COMPANY COM 191216100 9,087 207,176 SH   SOLE   196,571 0 10,605
COMCASTCORP NEW CL A COM 20030n101 238 7,265 SH   SOLE   1,365 0 5,900
CONOCOPHILLIPS COM 20825c104 476 6,835 SH   SOLE   6,835 0 0
CORE LABS COM N22717107 10,166 80,546 SH   SOLE   79,936 0 610
COSTCO WHOLESALE COM 22160k105 482 2,305 SH   SOLE   2,305 0 0
CVS CAREMARK CORP COM 126650100 7,083 110,074 SH   SOLE   105,444 0 4,630
DANAHER CORP COM COM 235851102 11,768 119,256 SH   SOLE   118,206 0 1,050
DISNEY WALT CO COM 254687106 10,040 95,792 SH   SOLE   91,977 0 3,815
DOLLAR GENERAL CORP COM 256677105 6,126 62,130 SH   SOLE   59,330 0 2,800
DOMINION RES INC VA NEW COM 25746u109 7,874 115,486 SH   SOLE   111,861 0 3,625
DOWDUPONT INC COM 26078j100 11,387 172,738 SH   SOLE   167,768 0 4,970
DUKE ENERGY CORPORATION NEW COM 26441c204 1,170 14,792 SH   SOLE   13,759 0 1,033
EBAY INC COM COM 278642103 267 7,365 SH   SOLE   2,415 0 4,950
ENBRIDGE INC COM 29250n105 692 19,381 SH   SOLE   14,644 0 4,737
ENDOCYTE INC COM 29269A102 309 22,425 SH   SOLE   2,425 0 20,000
EOG RESOURCES INC COM 26875p101 12,617 101,399 SH   SOLE   100,394 0 1,005
EXXON MOBIL CORP COM COM 30231G102 4,090 49,437 SH   SOLE   45,699 0 3,738
FACEBOOK COM 30303m102 17,396 89,522 SH   SOLE   88,587 0 935
FEDEXCORP COM 31428x106 385 1,695 SH   SOLE   195 0 1,500
FIBROGEN INC COM 31572q808 626 10,000 SH   SOLE   0 0 10,000
FIRST BANCORP NORTH CAROLINA COM 318910106 414 10,131 SH   SOLE   10,131 0 0
FIVE PRIME THERAPEUTICS, INC. COM 33830x104 158 10,000 SH   SOLE   0 0 10,000
FORTIVE CORP COM COM 34959j108 5,913 76,683 SH   SOLE   75,852 0 831
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 4,124 76,817 SH   SOLE   76,672 0 145
GENERAL DYNAMICS CRP COM 369550108 1,138 6,107 SH   SOLE   4,367 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 903 66,333 SH   SOLE   57,633 0 8,700
GENERAL MOTORS COM 37045v100 523 13,283 SH   SOLE   13,283 0 0
GILEAD SCIENCES INC COM COM 375558103 8,067 113,882 SH   SOLE   111,167 0 2,715
GOLDMAN SACHS GROUP INC COM 38141g104 4,352 19,730 SH   SOLE   18,500 0 1,230
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HERSHEY FOODS COM 427866108 594 6,380 SH   SOLE   6,325 0 55
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 190 12,988 SH   SOLE   12,988 0 0
HOME DEPOT INC COM COM 437076102 7,266 37,241 SH   SOLE   36,881 0 360
HONEYWELL INTERNATIONAL INC CO COM 438516106 10,788 74,894 SH   SOLE   72,914 0 1,980
HP, INC. COM 40434l105 273 12,050 SH   SOLE   12,050 0 0
IDEXX LABORATORIES COM 45168d104 11,577 53,120 SH   SOLE   52,715 0 405
ILLINOIS TOOL WORKS COM 452308109 554 4,000 SH   SOLE   4,000 0 0
INCYTE GENOMICS INC COM 45337c102 268 4,000 SH   SOLE   4,000 0 0
INSMED INC COM 457669307 385 16,300 SH   SOLE   16,300 0 0
INTEL CORP COM 458140100 1,056 21,239 SH   SOLE   21,239 0 0
INTL BUSINESS MACHINES COM 459200101 6,415 45,918 SH   SOLE   44,338 0 1,580
INTRA CELLULAR THERAPIES INC COM 46116x101 955 54,060 SH   SOLE   4,060 0 50,000
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,795 18,370 SH   SOLE   18,370 0 0
JAZZ PHARMACEUTICALS PLC COM g50871105 393 2,280 SH   SOLE   2,280 0 0
JOHNSON & JOHNSON COM 478160104 10,153 83,673 SH   SOLE   79,528 0 4,145
JPMORGAN CHASE & CO COM 46625h100 17,528 168,211 SH   SOLE   160,904 0 7,307
KINDER MORGAN INC COM 49456b101 1,407 79,641 SH   SOLE   69,076 0 10,565
KKR & CO LP COM 48248m102 432 17,375 SH   SOLE   17,375 0 0
KRAFT HEINZ CO. COM 500754106 6,186 98,478 SH   SOLE   94,048 0 4,430
LABORATORY CRP OF AMER HLDGS COM 50540r409 11,078 61,707 SH   SOLE   61,137 0 570
LINCOLN NATIONAL CORP COM 534187109 321 5,163 SH   SOLE   5,163 0 0
LOCKHEED MARTIN CORP COM 539830109 7,876 26,660 SH   SOLE   25,570 0 1,090
LOWE'S COS COM 548661107 320 3,352 SH   SOLE   3,352 0 0
MARRIOTT INTL NEW COM 571903202 7,949 62,786 SH   SOLE   62,231 0 555
MARTIN MARIETTA MATERIALS INC COM 573284106 10,274 46,005 SH   SOLE   45,590 0 415
MATTEL INC COM 577081102 246 15,000 SH   SOLE   15,000 0 0
MC DONALDS CORP COM 580135101 8,106 51,736 SH   SOLE   50,051 0 1,685
MELINTA THERAPEUTICS INC COM 58549G100 80 12,650 SH   SOLE   4,650 0 8,000
MERCK & CO INC NEW COM 58933y105 1,145 18,860 SH   SOLE   16,270 0 2,590
METLIFE INC COM 59156r108 6,680 153,200 SH   SOLE   147,550 0 5,650
MICROSOFT CORP COM 594918104 25,648 260,098 SH   SOLE   249,348 0 10,750
MONDELEZ INTL INC COM COM 609207105 10,321 251,724 SH   SOLE   249,504 0 2,220
NEKTAR THERAPEUTICS COM 640268108 2,832 58,000 SH   SOLE   58,000 0 0
NETFLIX COM INC COM 64110L106 391 1,000 SH   SOLE   1,000 0 0
NEXTERA ENERGY INC COM 65339f101 636 3,808 SH   SOLE   3,808 0 0
NIKE INC CL B COM 654106103 11,494 144,258 SH   SOLE   143,073 0 1,185
NORFOLK SOUTHERN CORP COM 655844108 2,216 14,685 SH   SOLE   14,685 0 0
NORTHROP GRUMMAN CORP COM 666807102 225 730 SH   SOLE   730 0 0
NOVELION THERAPEUTICS INC NEW COM 67001k202 96 26,000 SH   SOLE   20,000 0 6,000
NVIDIA CORP COM 67066g104 490 2,067 SH   SOLE   2,067 0 0
NXP SEMICONDUCTORS NV COM n6596x109 8,429 77,135 SH   SOLE   76,210 0 925
ORACLE CORP COM COM 68389X105 2,376 53,918 SH   SOLE   45,138 0 8,780
PAYCHEX INC COM 704326107 7,929 116,010 SH   SOLE   109,465 0 6,545
PAYPAL HOLDINGS INC COM 70450y103 17,193 206,467 SH   SOLE   201,792 0 4,675
PDL BIOPHARMA INC COM 69329y104 47 20,000 SH   SOLE   20,000 0 0
PEPSICO INCORPORATED COM 713448108 1,161 10,664 SH   SOLE   6,879 0 3,785
PFIZER INC COM 717081103 1,135 31,287 SH   SOLE   31,287 0 0
PHILIP MORRIS INTL INC COM 718172109 571 7,076 SH   SOLE   7,076 0 0
PHILLIPS 66 COM 718546104 421 3,752 SH   SOLE   3,752 0 0
PNC BK CORP COM COM 693475105 250 1,848 SH   SOLE   248 0 1,600
PROCTER & GAMBLE COM 742718109 1,540 19,728 SH   SOLE   16,808 0 2,920
PROQR THERAPEUTICS N.V. COM n71542109 657 90,000 SH   SOLE   0 0 90,000
PROTAGONIST THERAPEUTICS INC COM 74366E102 183 27,300 SH   SOLE   7,300 0 20,000
PUMA BIOTECHNOLOGY INC COM 74587v107 1,183 20,000 SH   SOLE   0 0 20,000
QUALCOMM INC COM COM 747525103 467 8,315 SH   SOLE   8,315 0 0
RAYONIER INC COM COM 754907103 290 7,500 SH   SOLE   7,500 0 0
REPLIGEN CORP COM 759916109 470 10,000 SH   SOLE   10,000 0 0
RIGEL PHARMACEUTICALS COM 766559603 59 21,000 SH   SOLE   21,000 0 0
ROYAL BANK OF CANADA COM 780087102 5,066 67,272 SH   SOLE   63,482 0 3,790
ROYAL DUTCH SHELL PLC SPON ADR COM 780259206 242 3,500 SH   SOLE   1,500 0 2,000
S&P GLOBAL INC COM 78409v104 299 1,466 SH   SOLE   1,466 0 0
SABINE ROYALTY TRUST UBI COM 785688102 942 20,000 SH   SOLE   20,000 0 0
SALESFORCE.COM INC COM 79466l302 208 1,527 SH   SOLE   1,527 0 0
SANGAMO BIOSCIENCES INC COM 800677106 588 41,400 SH   SOLE   11,400 0 30,000
SCHLUMBERGER LTD COM COM 806857108 8,758 130,661 SH   SOLE   124,686 0 5,975
SCHWAB (CHARLES) CORP COM 808513105 329 6,445 SH   SOLE   6,445 0 0
SELECT BANCORP INC NEW COM 81617l108 644 47,830 SH   SOLE   47,830 0 0
SOUTHERN CO COM 842587107 516 11,134 SH   SOLE   10,734 0 400
SQUARE INC COM COM 852234103 7,828 126,990 SH   SOLE   125,840 0 1,150
STANDARD & POOR'S DEP RCPTS COM 78462f103 3,800 14,009 SH   SOLE   12,509 0 1,500
STRYKER CORP COM 863667101 473 2,800 SH   SOLE   800 0 2,000
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,748 29,200 SH   SOLE   29,200 0 0
SYNTHETIC BIOLOGICS INC COM 87164u102 31 131,000 SH   SOLE   5,000 0 126,000
TAPESTRY INC COM 876030107 8,548 183,002 SH   SOLE   173,727 0 9,275
TARGET CORPORATION COM 87612e106 426 5,590 SH   SOLE   5,590 0 0
TEXTRON INC COM 883203101 236 3,585 SH   SOLE   3,585 0 0
THERMO FISHER CORP COM COM 883556102 4,759 22,974 SH   SOLE   22,594 0 380
TJX COMPANIES COM 872540109 252 2,650 SH   SOLE   0 0 2,650
TORONTO DOMINION BANK COM 891160509 252 4,360 SH   SOLE   4,360 0 0
TYME TECHNOLOGIES INC NEW COM 90238j103 130 41,000 SH   SOLE   1,000 0 40,000
UNION BANK COM 90520v103 5,300 323,164 SH   SOLE   323,164 0 0
UNITED HEALTHCARE CORP COM 91324p102 274 1,117 SH   SOLE   237 0 880
UNITED INSURANCE HOLDINGS CORP COM 910710102 2,643 135,000 SH   SOLE   135,000 0 0
UNITED PARCEL SERVICE - CL B COM 911312106 203 1,910 SH   SOLE   110 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 10,197 81,559 SH   SOLE   80,899 0 660
V F CORP COM 918204108 8,640 105,987 SH   SOLE   101,932 0 4,055
VERIZON COMMUNICATIONS COM 92343v104 9,002 178,932 SH   SOLE   173,374 0 5,558
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   SOLE   11,000 0 0
WASTE MANAGEMENT INC DEL COM 94106l109 8,107 99,673 SH   SOLE   95,753 0 3,920
WELLS FARGO & CO NEW COM 949746101 1,294 23,340 SH   SOLE   23,340 0 0
WILLIAMS CO INC COM 969457100 352 12,990 SH   SOLE   9,990 0 3,000
YUM BRANDS INC COM 988498101 7,005 89,555 SH   SOLE   88,890 0 665
ZOETIS INC COM 98978v103 343 4,026 SH   SOLE   4,026 0 0
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 360 10,000 SH   SOLE   10,000 0 0
VANGUARD FTSE ALL-WORLD ex-US ADR 922042775 207 4,000 SH   SOLE   4,000 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0
QLT INC WTS WT 746992171 0 230,000 SH   SOLE   200,000 0 30,000
QLT INC WTS WT 746992189 0 230,000 SH   SOLE   200,000 0 30,000