The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 740 3,145 SH   SOLE   3,145 0 0
ABBVIE INC COM COM 00287Y109 17,212 177,975 SH   SOLE   172,140 0 5,835
ACCENTURE PLC COM g1151c101 249 1,624 SH   SOLE   299 0 1,325
ADVAXIS INC COM 007624208 369 129,800 SH   SOLE   99,800 0 30,000
AFLAC INC COM COM 001055102 3,483 39,682 SH   SOLE   37,342 0 2,340
AIMMUNE THERAPEUTICS INC COM 00900t107 621 16,420 SH   SOLE   1,420 0 15,000
ALIBABA GROUP LTD SPR ADR COM 01609w102 650 3,767 SH   SOLE   3,767 0 0
ALLIANCE DATA SYSTEM CORP COM 018581108 4,675 18,444 SH   SOLE   18,229 0 215
ALPHABET INC CAP STK CL A COM 02079k305 1,649 1,565 SH   SOLE   1,365 0 200
ALPHABET INC CAP STK CL C COM 02079k107 17,863 17,071 SH   SOLE   16,680 0 391
ALTRIA GROUP INC COM 02209s103 382 5,355 SH   SOLE   5,355 0 0
AMAZON.COM INC COM 023135106 14,211 12,152 SH   SOLE   11,879 0 273
AMER ELEC PWR INC COM COM 025537101 360 4,890 SH   SOLE   4,890 0 0
AMERICAN EXPRESS CO COM COM 025816109 5,567 56,055 SH   SOLE   56,055 0 0
AMGEN INC COM COM 031162100 487 2,803 SH   SOLE   1,803 0 1,000
APPLE INC COM COM 037833100 30,018 177,377 SH   SOLE   170,720 0 6,657
ARALEZ PHARMACEUTICALS INC COM 03852x100 137 96,429 SH   SOLE   13,929 0 82,500
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,603 41,238 SH   SOLE   39,697 0 1,541
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 716 24,239 SH   SOLE   24,239 0 0
BB & T COM 054937107 1,575 31,668 SH   SOLE   30,066 0 1,602
BELLLICUM PHARMACEUTICALS INC COM 079481107 406 48,285 SH   SOLE   3,285 0 45,000
BERKSHIRE HATHAWAY-CL A COM 084670108 595 2 SH   SOLE   2 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 6,270 31,629 SH   SOLE   27,984 0 3,645
BIOCRYST PHARMACEUTICALS COM 09058v103 241 49,000 SH   SOLE   49,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BLACK STONE MINERALS LP COM 09225m101 502 28,000 SH   SOLE   28,000 0 0
BLACKHAWK NETWORK HOLDINGS COM 09238e104 392 11,007 SH   SOLE   11,007 0 0
BLACKROCK INC COM COM 09247X101 17,434 33,936 SH   SOLE   32,980 0 956
BOEING CO COM 097023105 1,847 6,262 SH   SOLE   6,262 0 0
BORG WARNER AUTOMOTIVE INC COM 099724106 2,329 45,585 SH   SOLE   44,635 0 950
BRISTOLMYERS SQUIBB COM 110122108 7,019 114,539 SH   SOLE   113,254 0 1,285
CALITHERA BIOSCIENCES, INC. COM 13089p101 464 55,580 SH   SOLE   15,580 0 40,000
CAPITAL ONE FINANCIAL COM 14040h105 398 4,000 SH   SOLE   4,000 0 0
CATERPILLAR INC COM 149123101 1,056 6,700 SH   SOLE   6,700 0 0
CHEVRON CORPORATION COM 166764100 10,028 80,103 SH   SOLE   76,468 0 3,635
CISCO SYS INC COM COM 17275R102 19,661 513,334 SH   SOLE   501,364 0 11,970
CME GROUP INC COM COM 12572Q105 24,405 167,097 SH   SOLE   161,997 0 5,100
COCA COLA COMPANY COM 191216100 9,625 209,776 SH   SOLE   199,471 0 10,305
COMCASTCORP NEW CL A COM 20030n101 595 14,852 SH   SOLE   9,202 0 5,650
COMMONWEALTH BANKSHARES INC (D COM 202736104 0 11,761 SH   SOLE   11,761 0 0
CONOCOPHILLIPS COM 20825c104 392 7,135 SH   SOLE   7,135 0 0
CORE LABS COM N22717107 8,436 77,005 SH   SOLE   76,395 0 610
COSTCO WHOLESALE COM 22160k105 468 2,515 SH   SOLE   2,515 0 0
CVS CAREMARK CORP COM 126650100 5,847 80,655 SH   SOLE   77,065 0 3,590
DANAHER CORP COM COM 235851102 10,313 111,110 SH   SOLE   110,035 0 1,075
DISCOVERY COMMUNICATIONS INC N COM 25470F302 399 18,830 SH   SOLE   18,830 0 0
DISNEY WALT CO COM 254687106 10,422 96,939 SH   SOLE   93,414 0 3,525
DOLLAR GENERAL CORP COM 256677105 237 2,550 SH   SOLE   300 0 2,250
DOMINION RES INC VA NEW COM 25746u109 727 8,968 SH   SOLE   6,468 0 2,500
DOWDUPONT INC COM 26078j100 11,271 158,257 SH   SOLE   152,854 0 5,403
DUKE ENERGY CORPORATION NEW COM 26441c204 1,468 17,454 SH   SOLE   16,371 0 1,083
EBAY INC COM COM 278642103 285 7,555 SH   SOLE   3,005 0 4,550
ECOLAB INC COM COM 278865100 230 1,717 SH   SOLE   1,617 0 100
ENBRIDGE INC COM 29250n105 656 16,766 SH   SOLE   10,391 0 6,375
EOG RESOURCES INC COM 26875p101 10,881 100,833 SH   SOLE   99,788 0 1,045
EXTENDED STAY AMERICA INC COM 30224p200 371 19,535 SH   SOLE   19,535 0 0
EXXON MOBIL CORP COM COM 30231G102 4,610 55,114 SH   SOLE   51,376 0 3,738
FACEBOOK COM 30303m102 13,255 75,117 SH   SOLE   74,257 0 860
FEDEXCORP COM 31428x106 443 1,775 SH   SOLE   275 0 1,500
FIBROCELL SCIENCE INC NEW COM 315721308 11 16,667 SH   SOLE   0 0 16,667
FIBROGEN INC COM 31572q808 474 10,000 SH   SOLE   0 0 10,000
FIRST BANCORP NORTH CAROLINA COM 318910106 358 10,131 SH   SOLE   10,131 0 0
FIRST CITIZENS BANCSHARES NC C COM 31946M103 1,404 3,483 SH   SOLE   0 0 3,483
FIVE PRIME THERAPEUTICS, INC. COM 33830x104 548 25,000 SH   SOLE   0 0 25,000
FNB CORP PA COM 302520101 139 10,027 SH   SOLE   10,027 0 0
FORTIVE CORP COM COM 34959j108 5,464 75,518 SH   SOLE   74,687 0 831
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 7,051 103,027 SH   SOLE   101,927 0 1,100
GENERAL DYNAMICS CRP COM 369550108 1,242 6,107 SH   SOLE   4,367 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 1,249 71,560 SH   SOLE   61,012 0 10,548
GENERAL MOTORS COM 37045v100 516 12,581 SH   SOLE   12,581 0 0
GILEAD SCIENCES INC COM COM 375558103 8,027 112,047 SH   SOLE   107,832 0 4,215
GOLDMAN SACHS GROUP INC COM 38141g104 3,763 14,772 SH   SOLE   13,567 0 1,205
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HEAT BIOLOGICS INC COM 42237K102 8 20,500 SH   SOLE   500 0 20,000
HERSHEY FOODS COM 427866108 16,193 142,658 SH   SOLE   137,898 0 4,760
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 187 13,051 SH   SOLE   12,988 0 63
HOME DEPOT INC COM COM 437076102 6,966 36,753 SH   SOLE   36,393 0 360
HONEYWELL INTERNATIONAL INC CO COM 438516106 11,235 73,262 SH   SOLE   71,277 0 1,985
HP, INC. COM 40434l105 254 12,113 SH   SOLE   12,050 0 63
IDEXX LABORATORIES COM 45168d104 7,306 46,720 SH   SOLE   46,340 0 380
ILLINOIS TOOL WORKS COM 452308109 667 4,000 SH   SOLE   4,000 0 0
INCYTE GENOMICS INC COM 45337c102 379 4,000 SH   SOLE   4,000 0 0
INSMED INC COM 457669307 490 15,700 SH   SOLE   15,700 0 0
INTEL CORP COM 458140100 1,150 24,918 SH   SOLE   24,868 0 50
INTL BUSINESS MACHINES COM 459200101 7,875 51,327 SH   SOLE   49,394 0 1,933
INTRA CELLULAR THERAPIES INC COM 46116x101 783 54,060 SH   SOLE   4,060 0 50,000
IQVIA HLDGS INC COM 46266C105 7,446 76,060 SH   SOLE   73,720 0 2,340
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,869 18,965 SH   SOLE   18,965 0 0
JAZZ PHARMACEUTICALS PLC COM g50871105 327 2,430 SH   SOLE   2,430 0 0
JOHNSON & JOHNSON COM 478160104 11,514 82,405 SH   SOLE   78,560 0 3,845
JPMORGAN CHASE & CO COM 46625h100 17,357 162,305 SH   SOLE   154,698 0 7,607
KINDER MORGAN INC COM 49456b101 1,443 79,871 SH   SOLE   69,176 0 10,695
KKR & CO LP COM 48248m102 366 17,375 SH   SOLE   17,375 0 0
KRAFT HEINZ CO. COM 500754106 5,724 73,614 SH   SOLE   70,214 0 3,400
LABORATORY CRP OF AMER HLDGS COM 50540r409 9,684 60,712 SH   SOLE   60,117 0 595
LINCOLN NATIONAL CORP COM 534187109 397 5,163 SH   SOLE   5,163 0 0
LOCKHEED MARTIN CORP COM 539830109 8,306 25,870 SH   SOLE   24,880 0 990
LOWE'S COS COM 548661107 469 5,048 SH   SOLE   5,048 0 0
LYONDELLBASELL INDUSTRIES NV O COM n53745100 4,201 38,079 SH   SOLE   37,259 0 820
MARRIOTT INTL NEW COM 571903202 8,478 62,465 SH   SOLE   61,910 0 555
MARTIN MARIETTA MATERIALS INC COM 573284106 10,021 45,335 SH   SOLE   44,870 0 465
MATTEL INC COM 577081102 231 15,000 SH   SOLE   15,000 0 0
MC DONALDS CORP COM 580135101 8,272 48,057 SH   SOLE   46,697 0 1,360
MELINTA THERAPEUTICS INC COM 58549G100 204 12,910 SH   SOLE   4,910 0 8,000
MERCK & CO INC NEW COM 58933y105 8,120 144,300 SH   SOLE   135,512 0 8,788
METLIFE INC COM 59156r108 7,778 153,841 SH   SOLE   148,191 0 5,650
MICROSOFT CORP COM 594918104 23,541 275,203 SH   SOLE   262,513 0 12,690
MONDELEZ INTL INC COM COM 609207105 7,894 184,448 SH   SOLE   182,603 0 1,845
MONSANTO CO COM 61166w101 357 3,060 SH   SOLE   1,660 0 1,400
NEKTAR THERAPEUTICS COM 640268108 3,464 58,000 SH   SOLE   58,000 0 0
NIKE INC CL B COM 654106103 8,674 138,679 SH   SOLE   137,499 0 1,180
NORFOLK SOUTHERN CORP COM 655844108 2,128 14,685 SH   SOLE   14,685 0 0
NORTHROP GRUMMAN CORP COM 666807102 224 730 SH   SOLE   730 0 0
NOVELION THERAPEUTICS INC NEW COM 67001k202 81 26,000 SH   SOLE   20,000 0 6,000
NVIDIA CORP COM 67066g104 400 2,067 SH   SOLE   2,067 0 0
ORACLE CORP COM COM 68389X105 3,258 68,907 SH   SOLE   60,077 0 8,830
PAYCHEX INC COM 704326107 7,502 110,189 SH   SOLE   103,644 0 6,545
PAYPAL HOLDINGS INC COM 70450y103 15,926 216,333 SH   SOLE   211,683 0 4,650
PDL BIOPHARMA INC COM 69329y104 55 20,000 SH   SOLE   20,000 0 0
PEPSICO INCORPORATED COM 713448108 1,202 10,026 SH   SOLE   7,436 0 2,590
PFIZER INC COM 717081103 1,206 33,300 SH   SOLE   33,300 0 0
PHILIP MORRIS INTL INC COM 718172109 760 7,196 SH   SOLE   7,196 0 0
PHILLIPS 66 COM 718546104 431 4,261 SH   SOLE   4,261 0 0
PHOENIX METALS CORP COM 71919B204 0 10,000 SH   SOLE   10,000 0 0
PNC BK CORP COM COM 693475105 267 1,848 SH   SOLE   248 0 1,600
PROCTER & GAMBLE COM 742718109 1,723 18,753 SH   SOLE   15,103 0 3,650
PROTAGONIST THERAPEUTICS INC COM 74366E102 971 46,700 SH   SOLE   6,700 0 40,000
PUMA BIOTECHNOLOGY INC COM 74587v107 2,175 22,000 SH   SOLE   0 0 22,000
QUALCOMM INC COM COM 747525103 525 8,201 SH   SOLE   8,201 0 0
RAYONIER INC COM COM 754907103 237 7,500 SH   SOLE   7,500 0 0
REPLIGEN CORP COM 759916109 363 10,000 SH   SOLE   10,000 0 0
RIGEL PHARMACEUTICALS COM 766559603 78 20,000 SH   SOLE   20,000 0 0
ROYAL BANK OF CANADA COM 780087102 5,493 67,272 SH   SOLE   63,482 0 3,790
ROYAL DUTCH SHELL PLC SPON ADR COM 780259206 233 3,500 SH   SOLE   1,500 0 2,000
S&P GLOBAL INC COM 78409v104 248 1,466 SH   SOLE   1,466 0 0
SABINE ROYALTY TRUST UBI COM 785688102 892 20,000 SH   SOLE   20,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 758 46,200 SH   SOLE   16,200 0 30,000
SCHLUMBERGER LTD COM COM 806857108 1,126 16,714 SH   SOLE   14,364 0 2,350
SELECT BANCORP INC NEW COM 81617l108 837 66,204 SH   SOLE   48,430 0 17,774
SHERWIN WILLIAMS CO COM 824348106 309 754 SH   SOLE   67 0 687
SNAP ON TOOLS CORP COM 833034101 2,601 14,920 SH   SOLE   14,755 0 165
SOUTHERN CO COM 842587107 7,377 153,396 SH   SOLE   151,086 0 2,310
SQUARE INC COM COM 852234103 2,839 81,900 SH   SOLE   80,975 0 925
STANDARD & POOR'S DEP RCPTS COM 78462f103 4,158 15,583 SH   SOLE   14,083 0 1,500
STARBUCKS CORP COM 855244109 6,766 117,809 SH   SOLE   116,774 0 1,035
STRYKER CORP COM 863667101 434 2,800 SH   SOLE   800 0 2,000
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,164 29,200 SH   SOLE   29,200 0 0
SYNTHETIC BIOLOGICS INC COM 87164u102 64 126,000 SH   SOLE   0 0 126,000
TAPESTRY INC COM 876030107 8,173 184,777 SH   SOLE   175,167 0 9,610
TARGET CORPORATION COM 87612e106 356 5,450 SH   SOLE   5,450 0 0
TEXAS INSTRUMENTS COM 882508104 330 3,156 SH   SOLE   1,656 0 1,500
TEXTRON INC COM 883203101 207 3,660 SH   SOLE   3,660 0 0
THERMO FISHER CORP COM COM 883556102 4,099 21,589 SH   SOLE   21,179 0 410
TJX COMPANIES COM 872540109 203 2,650 SH   SOLE   0 0 2,650
TRIMBLE INC. COM 896239100 3,415 84,035 SH   SOLE   83,060 0 975
TYME TECHNOLOGIES INC NEW COM 90238j103 198 31,000 SH   SOLE   1,000 0 30,000
UNION BANK COM 90520v103 5,511 331,959 SH   SOLE   330,374 0 1,585
UNITED HEALTHCARE CORP COM 91324p102 289 1,312 SH   SOLE   237 0 1,075
UNITED PARCEL SERVICE - CL B COM 911312106 250 2,099 SH   SOLE   299 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 10,101 79,184 SH   SOLE   78,524 0 660
V F CORP COM 918204108 6,185 83,580 SH   SOLE   79,875 0 3,705
VERIZON COMMUNICATIONS COM 92343v104 9,343 176,510 SH   SOLE   170,552 0 5,958
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   SOLE   11,000 0 0
WAL-MART STORES COM 931142103 224 2,267 SH   SOLE   402 0 1,865
WASTE MANAGEMENT INC DEL COM 94106l109 8,424 97,607 SH   SOLE   93,587 0 4,020
WELLS FARGO & CO NEW COM 949746101 1,421 23,415 SH   SOLE   23,415 0 0
WILLIAMS CO INC COM 969457100 244 8,000 SH   SOLE   5,000 0 3,000
YUM BRANDS INC COM 988498101 7,408 90,776 SH   SOLE   89,846 0 930
ZOETIS INC COM 98978v103 295 4,101 SH   SOLE   4,101 0 0
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 362 10,000 SH   SOLE   10,000 0 0
VANGUARD FTSE ALL-WORLD ex-US ADR 922042775 219 4,000 SH   SOLE   4,000 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0
QLT INC WTS WT 746992171 0 230,000 SH   SOLE   200,000 0 30,000
QLT INC WTS WT 746992189 0 230,000 SH   SOLE   200,000 0 30,000