The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 3,058 15,985 SH   SOLE   15,985 0 0
ABBVIE INC COM COM 00287Y109 12,464 191,279 SH   SOLE   184,319 0 6,960
ADVAXIS INC COM 007624208 717 87,800 SH   SOLE   57,800 0 30,000
AFLAC INC COM COM 001055102 2,772 38,282 SH   SOLE   35,942 0 2,340
AIMMUNE THERAPEUTICS INC COM 00900t107 450 20,700 SH   SOLE   700 0 20,000
AKAMAI TECHNOLOGIES INC COM 00971t101 5,603 93,845 SH   SOLE   91,765 0 2,080
ALLIANCE DATA SYSTEM CORP COM 018581108 4,275 17,169 SH   SOLE   17,139 0 30
ALPHABET INC CAP STK CL A COM 02079k305 1,188 1,401 SH   SOLE   1,201 0 200
ALPHABET INC CAP STK CL C COM 02079k107 14,804 17,845 SH   SOLE   17,459 0 386
ALTRIA GROUP INC COM 02209s103 638 8,938 SH   SOLE   8,938 0 0
AMAZON.COM INC COM 023135106 8,788 9,913 SH   SOLE   9,826 0 87
AMER ELEC PWR INC COM COM 025537101 328 4,890 SH   SOLE   4,890 0 0
AMERICAN EXPRESS CO COM COM 025816109 8,338 105,392 SH   SOLE   103,572 0 1,820
AMGEN INC COM COM 031162100 450 2,742 SH   SOLE   1,742 0 1,000
APPLE INC COM COM 037833100 28,899 201,159 SH   SOLE   193,953 0 7,206
ARALEZ PHARMACEUTICALS INC COM 03852x100 127 59,229 SH   SOLE   15,329 0 43,900
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,786 42,985 SH   SOLE   41,503 0 1,482
ATARA BIOTHERAPEUTICS INC COM 046513107 633 30,790 SH   SOLE   790 0 30,000
AUTOMATIC DATA PROCESSING COM 053015103 363 3,549 SH   SOLE   3,549 0 0
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 570 24,147 SH   SOLE   24,147 0 0
BB & T COM 054937107 1,477 33,044 SH   SOLE   31,942 0 1,102
BELLLICUM PHARMACEUTICALS INC COM 079481107 316 25,585 SH   SOLE   5,585 0 20,000
BERKSHIRE HATHAWAY-CL A COM 084670108 250 1 SH   SOLE   1 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 4,999 29,991 SH   SOLE   26,571 0 3,420
BIOCRYST PHARMACEUTICALS COM 09058v103 412 49,000 SH   SOLE   49,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BITZIO INC. COM 091751107 0 40,000 SH   SOLE   40,000 0 0
BLACK STONE MINERALS LP COM 09225m101 462 28,000 SH   SOLE   28,000 0 0
BLACKHAWK NETWORK HOLDINGS COM 09238e104 447 11,007 SH   SOLE   11,007 0 0
BLACKROCK INC COM COM 09247X101 11,652 30,383 SH   SOLE   29,457 0 926
BOEING CO COM 097023105 1,090 6,165 SH   SOLE   6,165 0 0
BRISTOLMYERS SQUIBB COM 110122108 5,517 101,458 SH   SOLE   100,098 0 1,360
CALITHERA BIOSCIENCES, INC. COM 13089p101 861 74,580 SH   SOLE   14,580 0 60,000
CAPITAL ONE FINANCIAL COM 14040h105 347 4,000 SH   SOLE   4,000 0 0
CATERPILLAR INC COM 149123101 636 6,860 SH   SOLE   6,860 0 0
CELGENE COM 151020104 1,307 10,500 SH   SOLE   10,500 0 0
CEMPRA INC COM 15130j109 320 85,250 SH   SOLE   5,250 0 80,000
CHEVRON CORPORATION COM 166764100 7,870 73,297 SH   SOLE   69,732 0 3,565
CISCO SYS INC COM COM 17275R102 12,947 383,052 SH   SOLE   373,362 0 9,690
CLOROX COMPANY COM 189054109 5,161 38,279 SH   SOLE   36,409 0 1,870
CME GROUP INC COM COM 12572Q105 20,681 174,084 SH   SOLE   168,919 0 5,165
COACH INC COM 189754104 6,986 169,038 SH   SOLE   158,103 0 10,935
COCA COLA COMPANY COM 191216100 1,656 39,014 SH   SOLE   32,614 0 6,400
COMCASTCORP NEW CL A COM 20030n101 411 10,924 SH   SOLE   5,374 0 5,550
COMMONWEALTH BANKSHARES INC (D COM 202736104 0 11,761 SH   SOLE   11,761 0 0
CONOCOPHILLIPS COM 20825c104 436 8,735 SH   SOLE   8,735 0 0
CORE LABS COM N22717107 6,396 55,370 SH   SOLE   54,860 0 510
COSTCO WHOLESALE COM 22160k105 429 2,556 SH   SOLE   2,556 0 0
DANAHER CORP COM COM 235851102 10,578 123,680 SH   SOLE   122,375 0 1,305
DEPOMED INC COM 249908104 251 20,000 SH   SOLE   10,000 0 10,000
DISCOVERY COMMUNICATIONS INC N COM 25470F302 1,127 39,804 SH   SOLE   39,524 0 280
DISNEY WALT CO COM 254687106 12,457 109,859 SH   SOLE   106,084 0 3,775
DOMINION RES INC VA NEW COM 25746u109 323 4,160 SH   SOLE   4,160 0 0
DOW CHEMICAL COM 260543103 714 11,236 SH   SOLE   11,236 0 0
DUKE ENERGY CORPORATION NEW COM 26441c204 1,358 16,562 SH   SOLE   15,179 0 1,383
DUPONT COM 263534109 835 10,393 SH   SOLE   10,393 0 0
EBAY INC COM COM 278642103 254 7,555 SH   SOLE   3,005 0 4,550
ECOLAB INC COM COM 278865100 270 2,152 SH   SOLE   1,937 0 215
ENBRIDGE INC COM 29250n105 666 15,919 SH   SOLE   9,804 0 6,115
EOG RESOURCES INC COM 26875p101 7,507 76,958 SH   SOLE   76,093 0 865
EXXON MOBIL CORP COM COM 30231G102 4,984 60,779 SH   SOLE   57,041 0 3,738
FACEBOOK COM 30303m102 9,398 66,162 SH   SOLE   65,437 0 725
FEDEXCORP COM 31428x106 369 1,890 SH   SOLE   390 0 1,500
FIBROCELL SCIENCE INC NEW COM 315721308 33 16,667 SH   SOLE   0 0 16,667
FIBROGEN INC COM 31572q808 247 10,000 SH   SOLE   0 0 10,000
FLOWERS FOODS INC COM 343498101 2,035 104,850 SH   SOLE   104,850 0 0
FORTIVE CORP COM COM 34959j108 4,266 70,843 SH   SOLE   70,097 0 746
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 7,459 122,576 SH   SOLE   121,496 0 1,080
FRANKLIN STR PARTNERS (restric COM franklin7 3,432 220,000 SH   SOLE   220,000 0 0
FRONTIER COMMUNICATIONS CORP COM 35906a108 43 20,061 SH   SOLE   20,061 0 0
GENERAL DYNAMICS CRP COM 369550108 1,125 6,010 SH   SOLE   4,270 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 8,047 270,049 SH   SOLE   253,049 0 17,000
GENERAL MOTORS COM 37045v100 495 13,997 SH   SOLE   11,220 0 2,777
GILEAD SCIENCES INC COM COM 375558103 4,727 69,595 SH   SOLE   65,940 0 3,655
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HARLEY-DAVIDSON COM 412822108 1,441 23,815 SH   SOLE   23,530 0 285
HEAT BIOLOGICS INC COM 42237K102 63 70,500 SH   SOLE   50,500 0 20,000
HERSHEY FOODS COM 427866108 14,763 135,133 SH   SOLE   130,318 0 4,815
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 288 12,172 SH   SOLE   12,172 0 0
HOME DEPOT INC COM COM 437076102 3,681 25,069 SH   SOLE   24,904 0 165
HONEYWELL INTERNATIONAL INC CO COM 438516106 8,760 70,151 SH   SOLE   68,211 0 1,940
HP, INC. COM 40434l105 215 12,050 SH   SOLE   12,050 0 0
IDEXX LABORATORIES COM 45168d104 3,477 22,490 SH   SOLE   22,490 0 0
ILLINOIS TOOL WORKS COM 452308109 542 4,092 SH   SOLE   4,092 0 0
INCYTE GENOMICS INC COM 45337c102 535 4,000 SH   SOLE   4,000 0 0
INSMED INC COM 457669307 663 37,885 SH   SOLE   35,385 0 2,500
INTEL CORP COM 458140100 781 21,658 SH   SOLE   21,658 0 0
INTL BUSINESS MACHINES COM 459200101 7,210 41,402 SH   SOLE   39,762 0 1,640
INTRA CELLULAR THERAPIES INC COM 46116x101 423 26,060 SH   SOLE   1,060 0 25,000
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,838 20,175 SH   SOLE   20,175 0 0
JOHNSON & JOHNSON COM 478160104 9,916 79,615 SH   SOLE   75,530 0 4,085
JPMORGAN CHASE & CO COM 46625h100 9,233 105,110 SH   SOLE   98,392 0 6,718
KINDER MORGAN INC COM 49456b101 1,758 80,886 SH   SOLE   70,886 0 10,000
KKR & CO LP COM 48248m102 292 16,000 SH   SOLE   16,000 0 0
KOHLS CORP COM 500255104 5,917 148,642 SH   SOLE   143,461 0 5,181
KRAFT HEINZ CO. COM 500754106 6,449 71,020 SH   SOLE   67,630 0 3,390
LABORATORY CRP OF AMER HLDGS COM 50540r409 7,502 52,287 SH   SOLE   51,797 0 490
LILLYELI & CO COM 532457108 320 3,800 SH   SOLE   3,800 0 0
LINCOLN NATIONAL CORP COM 534187109 374 5,713 SH   SOLE   5,713 0 0
LOCKHEED MARTIN CORP COM 539830109 6,742 25,195 SH   SOLE   24,080 0 1,115
LOWE'S COS COM 548661107 503 6,120 SH   SOLE   6,120 0 0
LYONDELLBASELL INDUSTRIES NV O COM n53745100 6,360 69,742 SH   SOLE   66,572 0 3,170
MARTIN MARIETTA MATERIALS INC COM 573284106 9,765 44,740 SH   SOLE   44,355 0 385
MATTEL INC COM 577081102 5,568 217,417 SH   SOLE   208,102 0 9,315
MC DONALDS CORP COM 580135101 7,110 54,855 SH   SOLE   52,878 0 1,977
MERCK & CO INC NEW COM 58933y105 7,668 120,680 SH   SOLE   114,527 0 6,153
METLIFE INC COM 59156r108 7,037 133,233 SH   SOLE   128,493 0 4,740
MICROCHIP TECH INC COM 595017104 232 3,147 SH   SOLE   3,147 0 0
MICROSOFT CORP COM 594918104 17,355 263,511 SH   SOLE   250,941 0 12,570
MONDELEZ INTL INC COM COM 609207105 6,541 151,832 SH   SOLE   150,272 0 1,560
MONSANTO CO COM 61166w101 8,753 77,320 SH   SOLE   75,200 0 2,120
NEKTAR THERAPEUTICS COM 640268108 1,361 58,000 SH   SOLE   58,000 0 0
NIKE INC CL B COM 654106103 5,240 94,024 SH   SOLE   93,149 0 875
NORFOLK SOUTHERN CORP COM 655844108 1,835 16,385 SH   SOLE   16,385 0 0
NORTHROP GRUMMAN CORP COM 666807102 205 862 SH   SOLE   862 0 0
NOVELION THERAPEUTICS INC NEW COM 67001k202 279 26,000 SH   SOLE   20,000 0 6,000
ORACLE CORP COM COM 68389X105 3,291 73,771 SH   SOLE   65,151 0 8,620
PARK STERLING COM 70086y105 189 15,384 SH   SOLE   15,384 0 0
PAYCHEX INC COM 704326107 5,851 99,336 SH   SOLE   92,821 0 6,515
PAYPAL HOLDINGS INC COM 70450y103 9,367 217,738 SH   SOLE   213,058 0 4,680
PDL BIOPHARMA INC COM 69329y104 51 22,500 SH   SOLE   20,000 0 2,500
PEPSICO INCORPORATED COM 713448108 6,632 59,289 SH   SOLE   56,294 0 2,995
PFIZER INC COM 717081103 1,104 32,281 SH   SOLE   32,281 0 0
PHILIP MORRIS INTL INC COM 718172109 769 6,814 SH   SOLE   6,814 0 0
PHILLIPS 66 COM 718546104 315 3,981 SH   SOLE   3,981 0 0
PHOENIX METALS CORP COM 71910B204 1 10,000 SH   SOLE   10,000 0 0
PNC BK CORP COM COM 693475105 222 1,848 SH   SOLE   248 0 1,600
PRAXAIR INC COM COM 74005P104 10,450 88,113 SH   SOLE   84,448 0 3,665
PROCTER & GAMBLE COM 742718109 1,788 19,898 SH   SOLE   16,978 0 2,920
PUMA BIOTECHNOLOGY INC COM 74587v107 1,116 30,000 SH   SOLE   0 0 30,000
QUALCOMM INC COM COM 747525103 433 7,551 SH   SOLE   7,551 0 0
RAYONIER INC COM COM 754907103 213 7,500 SH   SOLE   7,500 0 0
REPLIGEN CORP COM 759916109 352 10,000 SH   SOLE   10,000 0 0
REYNOLDS AMERICAN INC COM 761713106 716 11,358 SH   SOLE   10,794 0 564
RIGEL PHARMACEUTICALS COM 766559603 66 20,000 SH   SOLE   20,000 0 0
ROYAL BANK OF CANADA COM 780087102 8,396 115,150 SH   SOLE   111,360 0 3,790
ROYAL DUTCH SHELL PLC SPON ADR COM 780259206 217 4,110 SH   SOLE   2,110 0 2,000
SABINE ROYALTY TRUST UBI COM 785688102 712 20,000 SH   SOLE   20,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 398 76,500 SH   SOLE   16,500 0 60,000
SCANA CORP COM 80589m102 544 8,330 SH   SOLE   8,330 0 0
SCHLUMBERGER LTD COM COM 806857108 2,111 27,027 SH   SOLE   24,927 0 2,100
SCRIPSAMERICA INC COM COM 811066109 0 10,000 SH   SOLE   10,000 0 0
SNAP ON TOOLS CORP COM 833034101 2,382 14,120 SH   SOLE   14,000 0 120
SOUTHERN CO COM 842587107 6,318 126,914 SH   SOLE   121,494 0 5,420
STANDARD & POOR'S DEP RCPTS COM 78462f103 3,629 15,393 SH   SOLE   13,893 0 1,500
STARBUCKS CORP COM 855244109 5,906 101,149 SH   SOLE   96,644 0 4,505
STRYKER CORP COM 863667101 369 2,800 SH   SOLE   800 0 2,000
SUNLIFE FINANCIAL INC COM 866796105 373 10,197 SH   SOLE   10,197 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 970 31,000 SH   SOLE   31,000 0 0
SYNTHETIC BIOLOGICS INC COM 87164u102 79 126,000 SH   SOLE   0 0 126,000
TARGET CORPORATION COM 87612e106 291 5,268 SH   SOLE   5,198 0 70
THE LITTLE BANK, INC COM 53700p106 4,628 313,752 SH   SOLE   313,752 0 0
THERMO FISHER CORP COM COM 883556102 3,071 19,994 SH   SOLE   19,524 0 470
THRESHOLD PHARMACEUTICALS COM 885807206 40 70,000 SH   SOLE   0 0 70,000
TRIMBLE INC. COM 896239100 2,741 85,640 SH   SOLE   84,775 0 865
UNITED PARCEL SERVICE - CL B COM 911312106 422 3,932 SH   SOLE   2,132 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 8,396 74,823 SH   SOLE   74,113 0 710
VERIZON COMMUNICATIONS COM 92343v104 6,717 137,775 SH   SOLE   132,707 0 5,068
VIBE RECORDS INC NEW COM (DELI COM 925563108 0 11,000 SH   SOLE   11,000 0 0
WASTE MANAGEMENT INC DEL COM 94106l109 6,777 92,942 SH   SOLE   88,427 0 4,515
WELLS FARGO & CO NEW COM 949746101 1,437 25,824 SH   SOLE   25,824 0 0
WILLIAMS CO INC COM 969457100 237 8,000 SH   SOLE   5,000 0 3,000
YUM BRANDS INC COM 988498101 4,584 71,730 SH   SOLE   71,140 0 590
ZOETIS INC COM 98978v103 205 3,846 SH   SOLE   3,846 0 0
iSHARE MSCI TAIWAN CAPPED ETF ADR 46434g772 332 10,000 SH   SOLE   10,000 0 0
VANGUARD WORLD FUNDS FINANCIAL ADR 92204a405 243 4,026 SH   SOLE   4,026 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0
QLT INC WTS WT 746992171 0 280,000 SH   SOLE   250,000 0 30,000
QLT INC WTS WT 746992189 0 280,000 SH   SOLE   250,000 0 30,000