The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 3,141 17,592 SH   SOLE   17,592 0 0
AARONS INC CL A COM 002535300 360 11,250 SH   SOLE   11,250 0 0
ABBVIE INC COM COM 00287Y109 10,832 172,978 SH   SOLE   166,638 0 6,340
ADVAXIS INC COM 007624208 629 87,800 SH   SOLE   57,800 0 30,000
AFLAC INC COM COM 001055102 2,802 40,252 SH   SOLE   37,862 0 2,390
AKAMAI TECHNOLOGIES INC COM 00971t101 7,833 117,471 SH   SOLE   115,971 0 1,500
ALLIANCE DATA SYSTEM CORP COM 018581108 4,629 20,257 SH   SOLE   20,227 0 30
ALLIANT ENERGY CORP COM 018802108 220 5,813 SH   SOLE   5,813 0 0
ALPHABET INC CAP STK CL A COM 02079k305 1,809 2,283 SH   SOLE   2,083 0 200
ALPHABET INC CAP STK CL C COM 02079k107 14,789 19,161 SH   SOLE   18,875 0 286
ALTRIA GROUP INC COM 02209s103 362 5,355 SH   SOLE   5,355 0 0
AMAZON.COM INC COM 023135106 5,816 7,756 SH   SOLE   7,739 0 17
AMER ELEC PWR INC COM COM 025537101 308 4,890 SH   SOLE   4,890 0 0
AMERICAN EXPRESS CO COM COM 025816109 6,731 90,867 SH   SOLE   89,297 0 1,570
AMGEN INC COM COM 031162100 356 2,437 SH   SOLE   1,437 0 1,000
ANI PHARMACEUTICALS COM 00182C103 1,212 20,000 SH   SOLE   20,000 0 0
APPLE INC COM COM 037833100 25,613 221,141 SH   SOLE   214,655 0 6,486
ARALEZ PHARMACEUTICALS INC COM 03852x100 735 166,733 SH   SOLE   22,143 0 144,590
ARIAD PHARMACEUTICALS COM 04033a100 418 33,600 SH   SOLE   33,600 0 0
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,859 43,712 SH   SOLE   42,247 0 1,465
ATARA BIOTHERAPEUTICS INC COM 046513107 153 10,790 SH   SOLE   790 0 10,000
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 1,368 61,921 SH   SOLE   61,921 0 0
BB & T COM 054937107 1,327 28,231 SH   SOLE   27,129 0 1,102
BERKSHIRE HATHAWAY-CL A COM 084670108 2,197 9 SH   SOLE   9 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 5,222 32,041 SH   SOLE   28,601 0 3,440
BIOCRYST PHARMACEUTICALS COM 09058v103 310 49,000 SH   SOLE   49,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BITZIO INC. COM 091751107 0 40,000 SH   SOLE   40,000 0 0
BLACK STONE MINERALS LP COM 09225m101 526 28,000 SH   SOLE   28,000 0 0
BLACKHAWK NETWORK HOLDINGS COM 09238e104 415 11,007 SH   SOLE   11,007 0 0
BLACKROCK INC COM COM 09247X101 12,406 32,601 SH   SOLE   31,875 0 726
BNC BANCORP COM 05566t101 523 16,407 SH   SOLE   16,407 0 0
BOEING CO COM 097023105 2,979 19,135 SH   SOLE   19,135 0 0
BRISTOLMYERS SQUIBB COM 110122108 6,819 116,676 SH   SOLE   116,001 0 675
CALITHERA BIOSCIENCES, INC. COM 13089p101 405 124,580 SH   SOLE   14,580 0 110,000
CAPITAL ONE FINANCIAL COM 14040h105 353 4,044 SH   SOLE   4,044 0 0
CARDINAL HEALTH INC COM 14149Y108 346 4,802 SH   SOLE   4,802 0 0
CATERPILLAR INC COM 149123101 666 7,180 SH   SOLE   7,180 0 0
CELGENE COM 151020104 1,829 15,804 SH   SOLE   15,804 0 0
CEMPRA INC COM 15130j109 127 45,250 SH   SOLE   5,250 0 40,000
CHEVRON CORPORATION COM 166764100 8,156 69,298 SH   SOLE   66,203 0 3,095
CISCO SYS INC COM COM 17275R102 11,508 380,817 SH   SOLE   372,437 0 8,380
CLOROX COMPANY COM 189054109 5,753 47,933 SH   SOLE   45,943 0 1,990
CME GROUP INC COM COM 12572Q105 20,247 175,530 SH   SOLE   171,105 0 4,425
COACH INC COM 189754104 5,515 157,491 SH   SOLE   147,571 0 9,920
COCA COLA COMPANY COM 191216100 1,802 43,462 SH   SOLE   37,062 0 6,400
COMCASTCORP NEW CL A COM 20030n101 317 4,588 SH   SOLE   1,813 0 2,775
COMMONWEALTH BANKSHARES INC COM 202736104 0 11,761 SH   SOLE   11,761 0 0
CONOCOPHILLIPS COM 20825c104 474 9,448 SH   SOLE   9,448 0 0
CORE LABS COM N22717107 5,816 48,450 SH   SOLE   48,250 0 200
COSTCO WHOLESALE COM 22160k105 395 2,470 SH   SOLE   2,470 0 0
DANAHER CORP COM COM 235851102 9,656 124,050 SH   SOLE   123,385 0 665
DEPOMED INC COM 249908104 360 20,000 SH   SOLE   10,000 0 10,000
DISCOVER FINL SVCS INC COM 254709108 1,408 19,537 SH   SOLE   19,537 0 0
DISCOVERY COMMUNICATIONS INC N COM 25470F302 1,238 46,244 SH   SOLE   45,964 0 280
DISNEY WALT CO COM 254687106 12,778 122,610 SH   SOLE   119,275 0 3,335
DOMINION RES INC VA NEW COM 25746u109 328 4,285 SH   SOLE   4,285 0 0
DOW CHEMICAL COM 260543103 555 9,696 SH   SOLE   9,696 0 0
DUKE ENERGY CORPORATION NEW COM 26441c204 2,521 32,485 SH   SOLE   31,102 0 1,383
DUPONT COM 263534109 1,081 14,726 SH   SOLE   14,726 0 0
EBAY INC COM COM 278642103 226 7,628 SH   SOLE   3,078 0 4,550
ECOLAB INC COM COM 278865100 838 7,152 SH   SOLE   6,937 0 215
EOG RESOURCES INC COM 26875p101 8,583 84,901 SH   SOLE   84,651 0 250
ETF SPDR GOLD TRUST COM 78463v107 269 2,450 SH   SOLE   2,450 0 0
EXXON MOBIL CORP COM COM 30231G102 5,155 57,116 SH   SOLE   53,378 0 3,738
FACEBOOK COM 30303m102 7,420 64,493 SH   SOLE   64,303 0 190
FEDEXCORP COM 31428x106 397 2,130 SH   SOLE   1,130 0 1,000
FIBROCELL SCIENCE INC COM 315721209 32 50,000 SH   SOLE   0 0 50,000
FIBROGEN INC COM 31572q808 642 30,000 SH   SOLE   20,000 0 10,000
FIVE PRIME THERAPEUTICS, INC. COM 33830x104 251 5,000 SH   SOLE   0 0 5,000
FLOWERS FOODS INC COM 343498101 2,094 104,850 SH   SOLE   104,850 0 0
FORTIVE CORP COM COM 34959j108 3,671 68,450 SH   SOLE   68,119 0 331
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 6,648 124,351 SH   SOLE   124,101 0 250
FRONTIER COMMUNICATIONS CORP COM 35906a108 69 20,561 SH   SOLE   20,561 0 0
GENERAL DYNAMICS CRP COM 369550108 1,026 5,940 SH   SOLE   4,200 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 8,570 271,198 SH   SOLE   254,198 0 17,000
GENERAL MOTORS COM 37045v100 488 13,997 SH   SOLE   11,220 0 2,777
GILEAD SCIENCES INC COM COM 375558103 7,973 111,343 SH   SOLE   107,773 0 3,570
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HARLEY-DAVIDSON COM 412822108 1,577 27,025 SH   SOLE   26,740 0 285
HARMAN INTL INDS INC NEW COM COM 413086109 11,954 107,540 SH   SOLE   105,150 0 2,390
HEAT BIOLOGICS INC COM 42237K102 60 70,500 SH   SOLE   50,500 0 20,000
HERSHEY FOODS COM 427866108 13,706 132,510 SH   SOLE   128,365 0 4,145
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 279 12,050 SH   SOLE   12,050 0 0
HOME DEPOT INC COM COM 437076102 3,623 27,020 SH   SOLE   27,020 0 0
HONEYWELL INTERNATIONAL INC CO COM 438516106 9,012 77,791 SH   SOLE   76,196 0 1,595
HP, INC. COM 40434l105 179 12,050 SH   SOLE   12,050 0 0
IDEXX LABORATORIES COM 45168d104 2,714 23,140 SH   SOLE   23,140 0 0
ILLINOIS TOOL WORKS COM 452308109 490 4,000 SH   SOLE   4,000 0 0
INCYTE GENOMICS INC COM 45337c102 1,905 19,000 SH   SOLE   19,000 0 0
INSMED INC COM 457669307 794 60,029 SH   SOLE   57,529 0 2,500
INTEL CORP COM 458140100 847 23,349 SH   SOLE   23,349 0 0
INTL BUSINESS MACHINES COM 459200101 7,240 43,616 SH   SOLE   42,191 0 1,425
INTRA CELLULAR THERAPIES INC COM 46116x101 167 11,060 SH   SOLE   1,060 0 10,000
INTREXON CORP COM NPV COM 46122t102 243 10,000 SH   SOLE   10,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 651 13,612 SH   SOLE   12,012 0 1,600
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,815 20,495 SH   SOLE   20,495 0 0
JAZZ PHARMACEUTICALS PLC COM g50871105 780 7,150 SH   SOLE   7,150 0 0
JOHNSON & JOHNSON COM 478160104 10,310 89,491 SH   SOLE   85,721 0 3,770
JPMORGAN CHASE & CO COM 46625h100 1,330 15,411 SH   SOLE   11,353 0 4,058
KINDER MORGAN INC COM 49456b101 1,734 83,726 SH   SOLE   73,726 0 10,000
KKR & CO LP COM 48248m102 246 16,000 SH   SOLE   16,000 0 0
KOHLS CORP COM 500255104 6,642 134,506 SH   SOLE   130,250 0 4,256
KRAFT HEINZ CO. COM 500754106 4,933 56,490 SH   SOLE   54,185 0 2,305
LABORATORY CRP OF AMER HLDGS COM 50540r409 6,750 52,582 SH   SOLE   52,377 0 205
LAS VEGAS SANDS CORP COM 517834107 4,115 77,047 SH   SOLE   76,847 0 200
LINCOLN NATIONAL CORP COM 534187109 379 5,713 SH   SOLE   5,713 0 0
LOCKHEED MARTIN CORP COM 539830109 479 1,916 SH   SOLE   1,216 0 700
LOWE'S COS COM 548661107 490 6,887 SH   SOLE   6,887 0 0
LYONDELLBASELL INDUSTRIES NV O COM n53745100 945 11,020 SH   SOLE   9,520 0 1,500
MARTIN MARIETTA MATERIALS INC COM 573284106 11,080 50,015 SH   SOLE   49,780 0 235
MATTEL INC COM 577081102 5,478 198,852 SH   SOLE   191,072 0 7,780
MC DONALDS CORP COM 580135101 6,105 50,160 SH   SOLE   48,448 0 1,712
MEDTRONIC, PLC COM g5960l103 2,557 35,895 SH   SOLE   35,690 0 205
MERCK & CO INC NEW COM 58933y105 6,431 109,241 SH   SOLE   103,678 0 5,563
METLIFE INC COM 59156r108 7,058 130,979 SH   SOLE   126,959 0 4,020
MICROSOFT CORP COM 594918104 16,068 258,583 SH   SOLE   247,148 0 11,435
MONDELEZ INTL INC COM COM 609207105 4,055 91,462 SH   SOLE   90,457 0 1,005
MONSANTO CO COM 61166w101 6,557 62,320 SH   SOLE   60,700 0 1,620
MORGAN ST DEAN WITTER, DISC & COM 617446448 417 9,881 SH   SOLE   9,881 0 0
NEKTAR THERAPEUTICS COM 640268108 1,264 103,000 SH   SOLE   103,000 0 0
NIKE INC CL B COM 654106103 5,810 114,309 SH   SOLE   114,109 0 200
NORFOLK SOUTHERN CORP COM 655844108 1,587 14,685 SH   SOLE   14,685 0 0
NOVELION THERAPEUTICS INC NEW COM 67001k202 303 36,000 SH   SOLE   30,000 0 6,000
NXP SEMICONDUCTORS NV COM n6596x109 1,004 10,248 SH   SOLE   10,198 0 50
ORACLE CORP COM COM 68389X105 3,084 80,204 SH   SOLE   71,494 0 8,710
PARK STERLING COM 70086y105 166 15,384 SH   SOLE   15,384 0 0
PAYCHEX INC COM 704326107 5,644 92,713 SH   SOLE   86,823 0 5,890
PAYPAL HOLDINGS INC COM 70450y103 8,149 206,473 SH   SOLE   202,833 0 3,640
PDL BIOPHARMA INC COM 69329y104 48 22,500 SH   SOLE   20,000 0 2,500
PEPSICO INCORPORATED COM 713448108 6,559 62,688 SH   SOLE   60,028 0 2,660
PFIZER INC COM 717081103 1,109 34,145 SH   SOLE   34,145 0 0
PHILIP MORRIS INTL INC COM 718172109 619 6,766 SH   SOLE   6,766 0 0
PHILLIPS 66 COM 718546104 311 3,596 SH   SOLE   3,596 0 0
PNC BK CORP COM COM 693475105 933 7,973 SH   SOLE   6,373 0 1,600
PRAXAIR INC COM COM 74005P104 10,189 86,941 SH   SOLE   83,601 0 3,340
PROCTER & GAMBLE COM 742718109 1,803 21,449 SH   SOLE   18,529 0 2,920
PUMA BIOTECHNOLOGY INC COM 74587v107 890 29,000 SH   SOLE   9,000 0 20,000
QUALCOMM INC COM COM 747525103 497 7,616 SH   SOLE   7,616 0 0
REPLIGEN CORP COM 759916109 616 20,000 SH   SOLE   20,000 0 0
REYNOLDS AMERICAN INC COM 761713106 5,809 103,656 SH   SOLE   101,542 0 2,114
RIGEL PHARMACEUTICALS COM 766559603 48 20,000 SH   SOLE   20,000 0 0
ROYAL BANK OF CANADA COM 780087102 6,631 97,927 SH   SOLE   94,137 0 3,790
RYDER SYSTEM COM 783549108 809 10,863 SH   SOLE   10,863 0 0
S&P GLOBAL INC COM 78409v104 1,722 16,010 SH   SOLE   16,010 0 0
SABINE ROYALTY TRUST UBI COM 785688102 703 20,000 SH   SOLE   20,000 0 0
SCANA CORP COM 80589m102 664 9,055 SH   SOLE   9,055 0 0
SCHLUMBERGER LTD COM COM 806857108 2,321 27,652 SH   SOLE   25,552 0 2,100
SCRIPSAMERICA INC COM COM 811066109 0 10,000 SH   SOLE   10,000 0 0
SHIRE PLC SPONS ADR ISIN#US824 COM 82481r106 991 5,817 SH   SOLE   5,817 0 0
SNAP ON TOOLS CORP COM 833034101 2,478 14,470 SH   SOLE   14,350 0 120
SOUTHERN CO COM 842587107 5,857 119,077 SH   SOLE   114,442 0 4,635
SPECTRA ENERGY CORP COM 847560109 662 16,108 SH   SOLE   9,893 0 6,215
STANDARD & POOR'S DEP RCPTS COM 78462f103 3,454 15,453 SH   SOLE   13,953 0 1,500
STARBUCKS CORP COM 855244109 5,179 93,276 SH   SOLE   93,041 0 235
STRYKER CORP COM 863667101 335 2,800 SH   SOLE   800 0 2,000
SUNESIS PHARMACEUTICALS INC NE COM 867328700 121 33,332 SH   SOLE   0 0 33,332
SUPERNUS PHARMACEUTICALS INC COM 868459108 2,348 93,000 SH   SOLE   93,000 0 0
SYNTHETIC BIOLOGICS INC COM 87164u102 96 126,000 SH   SOLE   0 0 126,000
TARGET CORPORATION COM 87612e106 5,858 81,109 SH   SOLE   78,134 0 2,975
THE LITTLE BANK, INC COM 53700p106 4,110 313,752 SH   SOLE   313,752 0 0
THERMO FISHER CORP COM COM 883556102 2,741 19,429 SH   SOLE   19,219 0 210
THRESHOLD PHARMACEUTICALS COM 885807206 31 70,000 SH   SOLE   0 0 70,000
TRIMBLE INC. COM 896239100 2,545 84,410 SH   SOLE   84,310 0 100
ULTRAGENYX PHARMACEUTICAL INC COM 90400d108 735 10,450 SH   SOLE   10,450 0 0
UNITED PARCEL SERVICE - CL B COM 911312106 345 3,007 SH   SOLE   1,207 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 7,502 68,433 SH   SOLE   68,173 0 260
VALEANT PHARMACEUTICALS INTL COM 91911k102 268 18,470 SH   SOLE   18,470 0 0
VERIZON COMMUNICATIONS COM 92343v104 6,844 128,220 SH   SOLE   123,937 0 4,283
VIBE RECORDS INC NEW COM COM 925563108 0 11,000 SH   SOLE   11,000 0 0
W W GRAINGER INC COM 384802104 600 2,585 SH   SOLE   2,585 0 0
WASTE MANAGEMENT INC DEL COM 94106l109 6,129 86,433 SH   SOLE   82,588 0 3,845
WELLS FARGO & CO NEW COM 949746101 2,015 36,566 SH   SOLE   36,566 0 0
WILLIAMS CO INC COM 969457100 249 8,000 SH   SOLE   5,000 0 3,000
XENCOR, INC. COM 98401f105 869 33,000 SH   SOLE   33,000 0 0
ZOETIS INC COM 98978v103 224 4,186 SH   SOLE   4,186 0 0
iSHARE MSCI TAIWAN OLD ADR 464286731 301 10,250 SH   SOLE   10,250 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0
QLT INC WTS WT 746992171 0 280,000 SH   SOLE   250,000 0 30,000
QLT INC WTS WT 746992189 0 280,000 SH   SOLE   250,000 0 30,000