The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM COM 88579Y101 3,128 17,749 SH   SOLE   17,749 0 0
AARONS INC CL A COM 002535300 286 11,250 SH   SOLE   11,250 0 0
ABBVIE INC COM COM 00287Y109 10,355 164,178 SH   SOLE   157,238 0 6,940
ACCENTURE PLC COM g1151c101 200 1,639 SH   SOLE   314 0 1,325
ADVAXIS INC COM 007624208 975 91,200 SH   SOLE   61,200 0 30,000
AFLAC INC COM COM 001055102 3,079 42,842 SH   SOLE   40,452 0 2,390
AKAMAI TECHNOLOGIES INC COM 00971t101 6,282 118,547 SH   SOLE   117,047 0 1,500
ALLIANCE DATA SYSTEM CORP COM 018581108 4,599 21,439 SH   SOLE   21,409 0 30
ALLIANT ENERGY CORP COM 018802108 224 5,847 SH   SOLE   5,847 0 0
ALPHABET INC CAP STK CL A COM 02079k305 1,834 2,281 SH   SOLE   2,081 0 200
ALPHABET INC CAP STK CL C COM 02079k107 15,041 19,350 SH   SOLE   19,054 0 296
ALTRIA GROUP INC COM 02209s103 339 5,355 SH   SOLE   5,355 0 0
AMAZON.COM INC COM 023135106 4,513 5,390 SH   SOLE   5,373 0 17
AMER ELEC PWR INC COM COM 025537101 314 4,890 SH   SOLE   4,890 0 0
AMERICAN EXPRESS CO COM COM 025816109 5,291 82,627 SH   SOLE   81,057 0 1,570
AMGEN INC COM COM 031162100 407 2,442 SH   SOLE   1,442 0 1,000
ANI PHARMACEUTICALS COM 00182C103 1,924 29,000 SH   SOLE   20,000 0 9,000
APPLE INC COM COM 037833100 23,838 210,859 SH   SOLE   203,978 0 6,881
ARALEZ PHARMACEUTICALS INC COM 03852x100 809 166,733 SH   SOLE   22,143 0 144,590
ARIAD PHARMACEUTICALS COM 04033a100 460 33,600 SH   SOLE   33,600 0 0
ART ADVANCED RESEARCH TECHNOLO COM 04287x103 0 10,000 SH   SOLE   10,000 0 0
AT&T INC. COM 00206r102 1,726 42,505 SH   SOLE   41,105 0 1,400
ATARA BIOTHERAPEUTICS INC COM 046513107 214 10,000 SH   SOLE   0 0 10,000
AXION INTERNATIONAL HOLDINGS I COM 05462d101 0 95,714 SH   SOLE   95,714 0 0
BANK OF AMERICA CORP COM 060505104 959 61,270 SH   SOLE   61,270 0 0
BB & T COM 054937107 1,067 28,290 SH   SOLE   27,188 0 1,102
BERKSHIRE HATHAWAY-CL A COM 084670108 1,946 9 SH   SOLE   9 0 0
BERKSHIRE HATHAWAY INC DEL CL COM 084670702 4,733 32,763 SH   SOLE   29,323 0 3,440
BIOCRYST PHARMACEUTICALS COM 09058v103 216 49,000 SH   SOLE   49,000 0 0
BIOSIGNIA INC COM 090998345 0 130,000 SH   SOLE   130,000 0 0
BITZIO INC. COM 091751107 0 40,000 SH   SOLE   40,000 0 0
BLACK STONE MINERALS LP COM 09225m101 499 28,000 SH   SOLE   28,000 0 0
BLACKHAWK NETWORK HOLDINGS COM 09238e104 332 11,007 SH   SOLE   11,007 0 0
BLACKROCK INC COM COM 09247X101 11,900 32,832 SH   SOLE   32,106 0 726
BNC BANCORP COM 05566t101 423 17,407 SH   SOLE   17,407 0 0
BOEING CO COM 097023105 2,632 19,978 SH   SOLE   19,978 0 0
BRISTOLMYERS SQUIBB COM 110122108 6,093 113,010 SH   SOLE   112,335 0 675
CALITHERA BIOSCIENCES, INC. COM 13089p101 325 100,000 SH   SOLE   10,000 0 90,000
CAPITAL ONE FINANCIAL COM 14040h105 295 4,100 SH   SOLE   4,100 0 0
CARDINAL HEALTH INC COM 14149Y108 350 4,500 SH   SOLE   4,500 0 0
CATERPILLAR INC COM 149123101 651 7,328 SH   SOLE   7,328 0 0
CEMPRA INC COM 15130j109 1,146 47,350 SH   SOLE   27,350 0 20,000
CHEVRON CORPORATION COM 166764100 6,668 64,790 SH   SOLE   62,095 0 2,695
CISCO SYS INC COM COM 17275R102 11,409 359,679 SH   SOLE   352,499 0 7,180
CLOROX COMPANY COM 189054109 3,593 28,705 SH   SOLE   27,185 0 1,520
CME GROUP INC COM COM 12572Q105 18,493 176,929 SH   SOLE   171,864 0 5,065
COACH INC COM 189754104 5,268 144,082 SH   SOLE   135,362 0 8,720
COCA COLA COMPANY COM 191216100 1,706 40,315 SH   SOLE   35,915 0 4,400
COMCASTCORP NEW CL A COM 20030n101 260 3,923 SH   SOLE   1,148 0 2,775
COMMONWEALTH BANKSHARES INC COM 202736104 0 11,761 SH   SOLE   11,761 0 0
CONOCOPHILLIPS COM 20825c104 450 10,356 SH   SOLE   9,556 0 800
CORE LABS COM N22717107 4,875 43,400 SH   SOLE   43,210 0 190
COSTCO WHOLESALE COM 22160k105 384 2,515 SH   SOLE   2,515 0 0
CVS CAREMARK CORP COM 126650100 5,018 56,393 SH   SOLE   54,393 0 2,000
DANAHER CORP COM COM 235851102 6,757 86,195 SH   SOLE   85,530 0 665
DEPOMED INC COM 249908104 506 20,250 SH   SOLE   10,250 0 10,000
DISCOVER FINL SVCS INC COM 254709108 1,059 18,722 SH   SOLE   18,722 0 0
DISCOVERY COMMUNICATIONS INC N COM 25470F302 1,954 74,261 SH   SOLE   73,396 0 865
DISNEY WALT CO COM 254687106 8,251 88,854 SH   SOLE   85,079 0 3,775
DOMINION RES INC VA NEW COM 25746u109 323 4,350 SH   SOLE   4,350 0 0
DONNELLEYR R & SONS COM 257867101 315 20,046 SH   SOLE   20,046 0 0
DOW CHEMICAL COM 260543103 516 9,950 SH   SOLE   9,950 0 0
DUKE ENERGY CORPORATION NEW COM 26441c204 2,613 32,650 SH   SOLE   31,267 0 1,383
DUPONT COM 263534109 985 14,715 SH   SOLE   14,715 0 0
EBAY INC COM COM 278642103 229 6,965 SH   SOLE   2,415 0 4,550
ECOLAB INC COM COM 278865100 861 7,070 SH   SOLE   6,855 0 215
EOG RESOURCES INC COM 26875p101 8,186 84,648 SH   SOLE   84,398 0 250
ETF SPDR GOLD TRUST COM 78463v107 534 4,250 SH   SOLE   4,250 0 0
EXXON MOBIL CORP COM COM 30231G102 5,185 59,403 SH   SOLE   54,609 0 4,794
FACEBOOK COM 30303m102 4,880 38,045 SH   SOLE   37,970 0 75
FEDEXCORP COM 31428x106 367 2,100 SH   SOLE   1,100 0 1,000
FIBROCELL SCIENCE INC COM 315721209 36 50,000 SH   SOLE   0 0 50,000
FIBROGEN INC COM 31572q808 621 30,000 SH   SOLE   20,000 0 10,000
FIRST HORIZON NATIONAL CORP FR COM dca517101 0 39,871 SH   SOLE   39,871 0 0
FITBIT INC CL A COM 33812l102 1,744 117,525 SH   SOLE   117,525 0 0
FIVE PRIME THERAPEUTICS, INC. COM 33830x104 262 5,000 SH   SOLE   0 0 5,000
FLOWERS FOODS INC COM 343498101 829 54,850 SH   SOLE   54,850 0 0
FORTIVE CORP COM COM 34959j108 3,130 61,500 SH   SOLE   61,169 0 331
FORTUNE BRANDS HOMES & SEC INC COM 34964c106 7,214 124,171 SH   SOLE   123,921 0 250
FRONTIER COMMUNICATIONS CORP COM 35906a108 83 20,061 SH   SOLE   20,061 0 0
GENERAL DYNAMICS CRP COM 369550108 922 5,940 SH   SOLE   4,200 0 1,740
GENERAL ELECTRIC COMPANY COM 369604103 7,574 255,712 SH   SOLE   237,412 0 18,300
GENERAL MOTORS COM 37045v100 489 15,377 SH   SOLE   12,100 0 3,277
GILEAD SCIENCES INC COM COM 375558103 17,470 220,802 SH   SOLE   216,912 0 3,890
GROWLIFE, INC COM 39985x104 0 15,000 SH   SOLE   15,000 0 0
HARLEY-DAVIDSON COM 412822108 1,479 28,120 SH   SOLE   27,835 0 285
HARMAN INTL INDS INC NEW COM COM 413086109 12,178 144,200 SH   SOLE   141,570 0 2,630
HEAT BIOLOGICS INC COM 42237K102 97 70,500 SH   SOLE   50,500 0 20,000
HEWLETT PACKARD ENTERPRISE CO COM 42824c109 274 12,050 SH   SOLE   12,050 0 0
HOME DEPOT INC COM COM 437076102 3,439 26,722 SH   SOLE   26,722 0 0
HONEYWELL INTERNATIONAL INC CO COM 438516106 8,160 69,990 SH   SOLE   69,090 0 900
HP, INC. COM 40434l105 187 12,050 SH   SOLE   12,050 0 0
IDEXX LABORATORIES COM 45168d104 5,138 45,575 SH   SOLE   45,575 0 0
ILLINOIS TOOL WORKS COM 452308109 492 4,109 SH   SOLE   4,109 0 0
INCYTE GENOMICS INC COM 45337c102 1,792 19,000 SH   SOLE   19,000 0 0
INSMED INC COM 457669307 872 60,029 SH   SOLE   57,529 0 2,500
INTEL CORP COM 458140100 1,230 32,584 SH   SOLE   27,012 0 5,572
INTL BUSINESS MACHINES COM 459200101 6,570 41,362 SH   SOLE   39,842 0 1,520
INTRA CELLULAR THERAPIES INC COM 46116x101 615 40,350 SH   SOLE   30,350 0 10,000
INTREXON CORP COM NPV COM 46122t102 280 10,000 SH   SOLE   10,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100 499 13,612 SH   SOLE   12,012 0 1,600
ISHARES TR DOW JONES SEL DIVID COM 464287168 1,730 20,185 SH   SOLE   20,185 0 0
JAZZ PHARMACEUTICALS PLC COM g50871105 869 7,150 SH   SOLE   7,150 0 0
JOHNSON & JOHNSON COM 478160104 9,967 84,373 SH   SOLE   79,703 0 4,670
JOHNSON CONTROLS INTL PLC COM g51502105 233 5,014 SH   SOLE   5,014 0 0
JPMORGAN CHASE & CO COM 46625h100 1,046 15,711 SH   SOLE   11,153 0 4,558
KINDER MORGAN INC COM 49456b101 1,271 54,939 SH   SOLE   40,166 0 14,773
KOHLS CORP COM 500255104 5,559 127,056 SH   SOLE   120,787 0 6,269
KRAFT HEINZ CO. COM 500754106 5,698 63,658 SH   SOLE   61,353 0 2,305
LABORATORY CRP OF AMER HLDGS COM 50540r409 5,010 36,441 SH   SOLE   36,236 0 205
LAS VEGAS SANDS CORP COM 517834107 4,558 79,207 SH   SOLE   79,007 0 200
LINCOLN NATIONAL CORP COM 534187109 290 6,170 SH   SOLE   6,170 0 0
LIVE OAK BANCSHARES INC COM 53803x105 259 17,975 SH   SOLE   17,975 0 0
LOCKHEED MARTIN CORP COM 539830109 300 1,251 SH   SOLE   1,251 0 0
LOWE'S COS COM 548661107 536 7,425 SH   SOLE   7,425 0 0
MARTIN MARIETTA MATERIALS INC COM 573284106 9,042 50,485 SH   SOLE   50,250 0 235
MATTEL INC COM 577081102 5,542 183,032 SH   SOLE   174,742 0 8,290
MC DONALDS CORP COM 580135101 5,495 47,634 SH   SOLE   46,222 0 1,412
MEDIVATION INC COM 58501n101 4,070 50,000 SH   SOLE   50,000 0 0
MEDTRONIC, PLC COM g5960l103 7,897 91,395 SH   SOLE   91,190 0 205
MERCK & CO INC NEW COM 58933y105 6,278 100,595 SH   SOLE   92,824 0 7,771
METLIFE INC COM 59156r108 5,552 124,962 SH   SOLE   119,792 0 5,170
MICROSOFT CORP COM 594918104 14,592 253,334 SH   SOLE   241,524 0 11,810
MONDELEZ INTL INC COM COM 609207105 4,294 97,820 SH   SOLE   96,815 0 1,005
MONSANTO CO COM 61166w101 6,437 62,980 SH   SOLE   61,360 0 1,620
MORGAN ST DEAN WITTER, DISC & COM 617446448 317 9,881 SH   SOLE   9,881 0 0
NEKTAR THERAPEUTICS COM 640268108 1,770 103,000 SH   SOLE   103,000 0 0
NIKE INC CL B COM 654106103 5,941 112,845 SH   SOLE   112,645 0 200
NORDSTROM INC COM 655664100 2,344 45,188 SH   SOLE   45,088 0 100
NORFOLK SOUTHERN CORP COM 655844108 1,429 14,724 SH   SOLE   14,724 0 0
NXP SEMICONDUCTORS NV COM n6596x109 2,943 28,853 SH   SOLE   28,803 0 50
ORACLE CORP COM COM 68389X105 3,244 82,599 SH   SOLE   75,814 0 6,785
PARK STERLING COM 70086y105 125 15,384 SH   SOLE   15,384 0 0
PAYCHEX INC COM 704326107 4,811 83,140 SH   SOLE   76,750 0 6,390
PAYPAL HOLDINGS INC COM 70450y103 8,614 210,253 SH   SOLE   206,613 0 3,640
PDL BIOPHARMA INC COM 69329y104 75 22,500 SH   SOLE   20,000 0 2,500
PEPSICO INCORPORATED COM 713448108 4,647 42,719 SH   SOLE   40,079 0 2,640
PERRIGO COMPANY COM g97822103 4,152 44,970 SH   SOLE   44,920 0 50
PFIZER INC COM 717081103 1,173 34,628 SH   SOLE   34,628 0 0
PHILIP MORRIS INTL INC COM 718172109 669 6,882 SH   SOLE   6,882 0 0
PHILLIPS 66 COM 718546104 284 3,521 SH   SOLE   3,521 0 0
PNC BK CORP COM COM 693475105 718 7,973 SH   SOLE   6,373 0 1,600
PRAXAIR INC COM COM 74005P104 6,351 52,565 SH   SOLE   50,475 0 2,090
PROCTER & GAMBLE COM 742718109 8,713 97,083 SH   SOLE   89,668 0 7,415
PUMA BIOTECHNOLOGY INC COM 74587v107 1,991 29,700 SH   SOLE   9,700 0 20,000
QLT INC COM 746927102 577 280,000 SH   SOLE   250,000 0 30,000
QUALCOMM INC COM COM 747525103 444 6,486 SH   SOLE   6,486 0 0
REPLIGEN CORP COM 759916109 604 20,000 SH   SOLE   20,000 0 0
REYNOLDS AMERICAN INC COM 761713106 5,212 110,530 SH   SOLE   105,616 0 4,914
RIGEL PHARMACEUTICALS COM 766559603 73 20,000 SH   SOLE   20,000 0 0
ROYAL BANK OF CANADA COM 780087102 5,212 84,118 SH   SOLE   76,647 0 7,471
RYDER SYSTEM COM 783549108 715 10,847 SH   SOLE   10,847 0 0
S&P GLOBAL INC COM 78409v104 2,026 16,010 SH   SOLE   16,010 0 0
SABINE ROYALTY TRUST UBI COM 785688102 735 20,000 SH   SOLE   20,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 51 11,000 SH   SOLE   11,000 0 0
SCANA CORP COM 80589m102 661 9,139 SH   SOLE   9,139 0 0
SCHLUMBERGER LTD COM COM 806857108 2,144 27,267 SH   SOLE   24,867 0 2,400
SHIRE PLC SPONS ADR ISIN#US824 COM 82481r106 1,104 5,695 SH   SOLE   5,695 0 0
SNAP ON TOOLS CORP COM 833034101 2,275 14,970 SH   SOLE   14,850 0 120
SOUTHERN CO COM 842587107 5,310 103,509 SH   SOLE   98,649 0 4,860
SPECTRA ENERGY CORP COM 847560109 682 15,949 SH   SOLE   9,799 0 6,150
STANDARD & POOR'S DEP RCPTS COM 78462f103 2,270 10,493 SH   SOLE   8,993 0 1,500
STARBUCKS CORP COM 855244109 3,578 66,095 SH   SOLE   65,860 0 235
STRYKER CORP COM 863667101 326 2,800 SH   SOLE   800 0 2,000
SUNESIS PHARMACEUTICALS INC NE COM 867328700 146 33,332 SH   SOLE   0 0 33,332
SUPERNUS PHARMACEUTICALS INC COM 868459108 2,300 93,000 SH   SOLE   93,000 0 0
SYNTHETIC BIOLOGICS INC COM 87164u102 217 126,000 SH   SOLE   0 0 126,000
TARGET CORPORATION COM 87612e106 5,493 79,975 SH   SOLE   76,220 0 3,755
TEVA PHARMACEUTICAL INDUSTRIES COM 881624209 1,334 29,001 SH   SOLE   29,001 0 0
THE LITTLE BANK, INC COM 53700p106 4,183 298,812 SH   SOLE   298,812 0 0
THERMO FISHER CORP COM COM 883556102 3,175 19,961 SH   SOLE   19,751 0 210
THRESHOLD PHARMACEUTICALS COM 885807206 47 70,000 SH   SOLE   0 0 70,000
TRIMBLE INC. COM 896239100 1,737 60,810 SH   SOLE   60,710 0 100
ULTRAGENYX PHARMACEUTICAL INC COM 90400d108 745 10,500 SH   SOLE   10,500 0 0
UNDER ARMOUR INC COM 904311107 693 20,470 SH   SOLE   20,470 0 0
UNITED PARCEL SERVICE - CL B COM 911312106 355 3,248 SH   SOLE   1,448 0 1,800
UNITED TECHNOLOGIES CORP COM COM 913017109 5,277 51,943 SH   SOLE   51,693 0 250
VALEANT PHARMACEUTICALS INTL COM 91911k102 453 18,470 SH   SOLE   18,470 0 0
VERIZON COMMUNICATIONS COM 92343v104 5,896 113,426 SH   SOLE   108,953 0 4,473
VIBE RECORDS INC NEW COM COM 925563108 0 11,000 SH   SOLE   11,000 0 0
W W GRAINGER INC COM 384802104 607 2,700 SH   SOLE   2,700 0 0
WALGREENS BOOTS ALLIANCE INC. COM 931427108 319 3,956 SH   SOLE   956 0 3,000
WASTE MANAGEMENT INC DEL COM 94106l109 5,158 80,892 SH   SOLE   77,047 0 3,845
WELLS FARGO & CO NEW COM 949746101 4,833 109,156 SH   SOLE   102,886 0 6,270
WILLIAMS CO INC COM 969457100 249 8,109 SH   SOLE   5,109 0 3,000
XENCOR, INC. COM 98401f105 808 33,000 SH   SOLE   33,000 0 0
iSHARE MSCI TAIWAN ADR 464286731 314 20,000 SH   SOLE   20,000 0 0
AMERIC INT GR WTS EXP 1/19/202 WT acg874152 0 100,444 SH   SOLE   100,444 0 0
FOREST LABORATORIES CONTINGENT WT 187cvr907 0 55,000 SH   SOLE   55,000 0 0
FOREST LABORATORIES INC CONTIN WT 3458cvr07 0 15,000 SH   SOLE   15,000 0 0