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<edgarSubmission xsi:schemaLocation="http://www.sec.gov/edgar/thirteenffiler eis_13F_Filer.xsd" xmlns="http://www.sec.gov/edgar/thirteenffiler" xmlns:ns1="http://www.sec.gov/edgar/common" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
    <submissionType>13F-NT/A</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>true</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001009268</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>09-30-2013</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>09-30-2013</reportCalendarOrQuarter>
      <isAmendment>true</isAmendment>
      <amendmentNo>1</amendmentNo>
      <amendmentInfo>
        <amendmentType>RESTATEMENT</amendmentType>
        <confDeniedExpired>false</confDeniedExpired>
      </amendmentInfo>
      <filingManager>
        <name>D. E. SHAW &amp; CO, L.P.</name>
        <address>
          <ns1:street1>1166 Avenue Of The Americas</ns1:street1>
          <ns1:street2>Ninth Floor</ns1:street2>
          <ns1:city>New York</ns1:city>
          <ns1:stateOrCountry>NY</ns1:stateOrCountry>
          <ns1:zipCode>10036</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-05394</form13FFileNumber>
      <otherManagersInfo>
        <otherManager>
          <cik>0001009207</cik>
          <form13FFileNumber>028-05396</form13FFileNumber>
          <name>D. E. Shaw &amp; Co., Inc.</name>
        </otherManager>
      </otherManagersInfo>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation> <![CDATA[D. E. Shaw & Co., Inc. may be deemed an institutional investment manager in its capacity as the general partner of D. E. Shaw & Co., L.P., which in turn is the managing member of certain other affiliated institutional investment managers. D. E. Shaw & Co., Inc. does not exercise investment or voting discretion, and therefore disclaims such discretion, with respect to Section 13(f) securities. D. E. Shaw & Co., L.P. may be deemed to exercise investment or voting discretion for affiliated institutional investment managers. D. E. Shaw & Co., L.P. does not exercise investment or voting discretion, and therefore disclaims such discretion, with respect to Section 13(f) securities over which such affiliated institutional investment managers exercise investment or voting discretion. D. E. Shaw Heliant Adviser, L.L.C. submitted a Form 13F Notice on November 14, 2013 that, due to an error by its financial printer, inadvertently included an erroneous Form 13F Information Table (the "Table"). The Table did not represent positions held by D. E. Shaw Heliant Adviser, L.L.C. or any affiliate of the D. E. Shaw group, and no Table was intended to be included. D. E. Shaw & Co., Inc., as the Reporting Manager, is filing an amended and restated Form 13F-HR/A in order to replace the one that includes the erroneous Table that was submitted by its financial printer.]]> </additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Nathan Thomas</name>
      <title>Chief Compliance Officer</title>
      <phone>212-478-0000</phone>
      <signature>/s/ Nathan Thomas</signature>
      <city>New York</city>
      <stateOrCountry>NY</stateOrCountry>
      <signatureDate>11-20-2013</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount/>
      <tableEntryTotal/>
      <tableValueTotal/>
    </summaryPage>
  </formData>
</edgarSubmission>
