SCHEDULE 13G/A 0001104659-25-102591 0001009268 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value per share 12/31/2025 0001664710 Keros Therapeutics, Inc. 492327101 1050 Waltham Street, Suite 302 Lexington MA 02421 Rule 13d-1(c) D. E. Shaw & Co., L.P. DE 0.00 756156.00 0.00 756156.00 756156.00 N 3.9 IA PN D. E. Shaw & Co., L.L.C. DE 0.00 755473.00 0.00 755473.00 755473.00 N 3.9 OO David E. Shaw X1 0.00 756156.00 0.00 756156.00 756156.00 N 3.9 IN Keros Therapeutics, Inc. 1050 Waltham Street, Suite 302, Lexington, MA 02421 D. E. Shaw & Co., L.P. D. E. Shaw & Co., L.L.C. David E. Shaw The business address for each reporting person is: Two Manhattan West 375 Ninth Avenue, 52nd Floor New York, NY 10001 D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. D. E. Shaw & Co., L.L.C. is a limited liability company organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America. Y D. E. Shaw & Co., L.P.: 756,156 shares This is composed of (i) 527,201 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 228,258 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 14 shares in the name of D. E. Shaw Composite Portfolios, L.L.C., and (iv) 683 shares under the management of D. E. Shaw Investment Management, L.L.C. D. E. Shaw & Co., L.L.C.: 755,473 shares This is composed of (i) 527,201 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 228,258 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 14 shares in the name of D. E. Shaw Composite Portfolios, L.L.C. David E. Shaw: 756,156 shares This is composed of (i) 527,201 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 228,258 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 14 shares in the name of D. E. Shaw Composite Portfolios, L.L.C., and (iv) 683 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw does not own any shares directly. By virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Valence Portfolios, L.L.C., D. E. Shaw Oculus Portfolios, L.L.C., and D. E. Shaw Composite Portfolios, L.L.C. and the managing member of D. E. Shaw Investment Management, L.L.C., and by virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Valence Portfolios, L.L.C., D. E. Shaw Oculus Portfolios, L.L.C., and D. E. Shaw Composite Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of, and the shared power to dispose or direct the disposition of, the 756,156 shares as described above constituting 3.9% of the outstanding shares, and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 756,156 shares. D. E. Shaw & Co., L.P.: 3.9% D. E. Shaw & Co., L.L.C.: 3.9% David E. Shaw: 3.9% D. E. Shaw & Co., L.P.: 0 shares D. E. Shaw & Co., L.L.C.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 756,156 shares D. E. Shaw & Co., L.L.C.: 755,473 shares David E. Shaw: 756,156 shares D. E. Shaw & Co., L.P.: 0 shares D. E. Shaw & Co., L.L.C.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 756,156 shares D. E. Shaw & Co., L.L.C.: 755,473 shares David E. Shaw: 756,156 shares N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 3: Joint Filing Agreement, by and among the Reporting Persons, dated February 17, 2026. D. E. Shaw & Co., L.P. /s/ Daniel R. Marcus 02/17/2026 D. E. Shaw & Co., L.L.C. /s/ Daniel R. Marcus 02/17/2026 David E. Shaw /s/ Daniel R. Marcus 02/17/2026 Exhibit 1: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co., Inc., in favor of the signatories hereto, among others, dated August 1, 2024. Exhibit 2: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co. II, Inc., in favor of the signatories hereto, among others, dated August 1, 2024.