SCHEDULE 13G/A 0001104659-25-070827 0001009268 XXXXXXXX LIVE 2 Common Stock, $0.0001 par value per share 09/30/2025 0000873303 Sarepta Therapeutics, Inc. 803607100 215 First Street Suite 415 Cambridge MA 02142 Rule 13d-1(c) D. E. Shaw & Co., L.P. DE 0.00 1984525.00 0.00 2007025.00 2007025.00 N 1.9 IA PN David E. Shaw X1 0.00 1984525.00 0.00 2007025.00 2007025.00 N 1.9 IN Sarepta Therapeutics, Inc. 215 First Street, Suite 415, Cambridge, MA 02142 D. E. Shaw & Co., L.P. David E. Shaw The business address for each reporting person is: Two Manhattan West 375 Ninth Avenue, 52nd Floor New York, NY 10001 D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America. Y D. E. Shaw & Co., L.P.: 2,007,025 shares This is composed of (i) 1,469,536 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (ii) 235,509 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., and (iii) 301,980 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw: 2,007,025 shares This is composed of (i) 1,469,536 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (ii) 235,509 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., and (iii) 301,980 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw does not own any shares directly. By virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Oculus Portfolios, L.L.C. and D. E. Shaw Valence Portfolios, L.L.C. and the managing member of D. E. Shaw Investment Management, L.L.C., and by virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Oculus Portfolios, L.L.C. and D. E. Shaw Valence Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of 1,984,525 shares, and the shared power to dispose or direct the disposition of 2,007,025 shares, the 2,007,025 shares as described above constituting 1.9% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 2,007,025 shares. D. E. Shaw & Co., L.P.: 1.9% David E. Shaw: 1.9% D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 1,984,525 shares David E. Shaw: 1,984,525 shares D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 2,007,025 shares David E. Shaw: 2,007,025 shares N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 2: Joint Filing Agreement, by and among the Reporting Persons, dated November 14, 2025. D. E. Shaw & Co., L.P. /s/ Daniel R. Marcus 11/14/2025 David E. Shaw /s/ Daniel R. Marcus 11/14/2025 Exhibit 1: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co., Inc., in favor of the signatories hereto, among others, dated August 1, 2024.