<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xmlns="http://www.sec.gov/edgar/npx" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>N-PX</submissionType>
    <filerInfo>
      <registrantType>IM</registrantType>
      <liveTestFlag>LIVE</liveTestFlag>
      <filer>
        <issuerCredentials>
          <cik>0001009268</cik>
          <ccc>XXXXXXXX</ccc>
          <!--Field: Pseudo-Tag; ID: Name; Data:-->
        </issuerCredentials>
      </filer>
      <flags>
        <overrideInternetFlag>false</overrideInternetFlag>
        <confirmingCopyFlag>false</confirmingCopyFlag>
      </flags>
      <periodOfReport>06/30/2025</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <yearOrQuarter>YEAR</yearOrQuarter>
      <reportCalendarYear>2025</reportCalendarYear>
      <reportingPerson>
        <name>D. E. SHAW &amp; CO, L.P.</name>
        <phoneNumber>212-478-0000</phoneNumber>
        <address>
          <com:street1>Two Manhattan West</com:street1>
          <com:street2>375 Ninth Avenue, 52nd Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10001</com:zipCode>
        </address>
      </reportingPerson>
      <reportInfo>
        <reportType>INSTITUTIONAL MANAGER NOTICE REPORT</reportType>
        <noticeExplanation>ALL VOTES BY OTHER PERSONS</noticeExplanation>
        <confidentialTreatment>N</confidentialTreatment>
      </reportInfo>
      <fileNumber>028-05394</fileNumber>
      <reportingCrdNumber>000108679</reportingCrdNumber>
      <reportingSecFileNumber>801-56171</reportingSecFileNumber>
      <leiNumber>TNWE6LERP1CI9IDAZB80</leiNumber>
      <otherManagersInfo>
        <otherManager>
          <icaOr13FFileNumber>028-05396</icaOr13FFileNumber>
          <managerName>D. E. Shaw &amp; Co., Inc.</managerName>
        </otherManager>
      </otherManagersInfo>
      <explanatoryInformation>
        <explanatoryChoice>Y</explanatoryChoice>
        <explanatoryNotes>D. E. Shaw &amp; Co., Inc. may be deemed an institutional investment manager in its capacity as the general partner of D. E. Shaw &amp; Co., L.P., which in turn is the managing member of certain other affiliated institutional investment managers. D. E. Shaw &amp; Co., Inc. does not exercise investment or voting discretion, and therefore disclaims such discretion, with respect to the securities reported herein. D. E. Shaw &amp; Co., L.P. may be deemed to exercise investment or voting discretion for affiliated institutional investment managers. D. E. Shaw &amp; Co., L.P. does not exercise investment or voting discretion, and therefore disclaims such discretion, with respect to the securities over which such affiliated institutional investment managers exercise investment or voting discretion.</explanatoryNotes>
      </explanatoryInformation>
    </coverPage>
    <signaturePage>
      <reportingPerson>D. E. SHAW &amp; CO, L.P.</reportingPerson>
      <txSignature>Daniel R. Marcus</txSignature>
      <txPrintedSignature>Daniel R. Marcus</txPrintedSignature>
      <txTitle>Chief Compliance Officer</txTitle>
      <txAsOfDate>09/02/2025</txAsOfDate>
    </signaturePage>
  </formData>
</edgarSubmission>
