SCHEDULE 13G/A 0001104659-24-129755 0001009268 XXXXXXXX LIVE 2 Common Shares of Beneficial Interest 06/30/2025 0001456772 Office Properties Income Trust 67623C109 Two Newton Place, 255 Washington Street, Suite 300, Newton MA 02458-1634 Rule 13d-1(c) D. E. Shaw & Co., L.P. DE 0.00 2596642.00 0.00 2596642.00 2596642.00 N 3.5 IA PN David E. Shaw X1 0.00 2596642.00 0.00 2596642.00 2596642.00 N 3.5 IN Office Properties Income Trust Two Newton Place, 255 Washington Street, Suite 300, Newton, MA 02458-1634 D. E. Shaw & Co., L.P. David E. Shaw The business address for each reporting person is: Two Manhattan West 375 Ninth Avenue, 52nd Floor New York, NY 10001 D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America. Y D. E. Shaw & Co., L.P.: 2,596,642 shares This is composed of (i) 2,523,141 shares in the name of D. E. Shaw Galvanic Portfolios, L.L.C., (ii) 72,001 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., and (iii) 1,500 shares in the name of D. E. Shaw Composite Portfolios, L.L.C. David E. Shaw: 2,596,642 shares This is composed of (i) 2,523,141 shares in the name of D. E. Shaw Galvanic Portfolios, L.L.C., (ii) 72,001 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., and (iii) 1,500 shares in the name of D. E. Shaw Composite Portfolios, L.L.C. David E. Shaw does not own any shares directly. By virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Valence Portfolios, L.L.C., and D. E. Shaw Composite Portfolios, L.L.C. and the managing member of D. E. Shaw Adviser II, L.L.C., which in turn is the investment adviser of D. E. Shaw Galvanic Portfolios, L.L.C., and by virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Valence Portfolios, L.L.C., and D. E. Shaw Composite Portfolios, L.L.C. and the managing member of D. E. Shaw Manager II, L.L.C., which in turn is the manager of D. E. Shaw Galvanic Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of, and the shared power to dispose or direct the disposition of, the 2,596,642 shares as described above constituting 3.5% of the outstanding shares, and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 2,596,642 shares. D. E. Shaw & Co., L.P.: 3.5% David E. Shaw: 3.5% D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 2,596,642 shares David E. Shaw: 2,596,642 shares D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 2,596,642 shares David E. Shaw: 2,596,642 shares N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 2: Joint Filing Agreement, by and among the Reporting Persons, dated August 14, 2025. D. E. Shaw & Co., L.P. /s/ Daniel R. Marcus 08/14/2025 David E. Shaw /s/ Daniel R. Marcus 08/14/2025 Exhibit 1: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co., Inc., in favor of the signatories hereto, among others, dated August 1, 2024.