SCHEDULE 13G/A 0001104659-25-070827 0001009268 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value per share 07/18/2025 0000873303 Sarepta Therapeutics, Inc. 803607100 215 First Street, Suite 415, Cambridge MA 02142 Rule 13d-1(c) D. E. Shaw & Co., L.P. DE 0.00 5000212.00 0.00 5059912.00 5059912.00 N 5.1 IA PN David E. Shaw X1 0.00 5000212.00 0.00 5059912.00 5059912.00 N 5.1 IN Sarepta Therapeutics, Inc. 215 First Street, Suite 415, Cambridge, MA 02142 D. E. Shaw & Co., L.P. David E. Shaw The business address for each reporting person is: Two Manhattan West 375 Ninth Avenue, 52nd Floor New York, NY 10001 D. E. Shaw & Co., L.P. is a limited partnership organized under the laws of the state of Delaware. David E. Shaw is a citizen of the United States of America. Y D. E. Shaw & Co., L.P.: 5,059,912 shares This is composed of (i) 2,781,337 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,391,459 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 887,116 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw: 5,059,912 shares This is composed of (i) 2,781,337 shares in the name of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,391,459 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 887,116 shares under the management of D. E. Shaw Investment Management, L.L.C. David E. Shaw does not own any shares directly. By virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co., Inc., which is the general partner of D. E. Shaw & Co., L.P., which in turn is the investment adviser of D. E. Shaw Valence Portfolios, L.L.C. and D. E. Shaw Oculus Portfolios, L.L.C. and the managing member of D. E. Shaw Investment Management, L.L.C., and by virtue of David E. Shaw's position as President and sole shareholder of D. E. Shaw & Co. II, Inc., which is the managing member of D. E. Shaw & Co., L.L.C., which in turn is the manager of D. E. Shaw Valence Portfolios, L.L.C. and D. E. Shaw Oculus Portfolios, L.L.C., David E. Shaw may be deemed to have the shared power to vote or direct the vote of 5,000,212 shares, and the shared power to dispose or direct the disposition of 5,059,912 shares, the 5,059,912 shares as described above constituting 5.1% of the outstanding shares and, therefore, David E. Shaw may be deemed to be the beneficial owner of such shares. David E. Shaw disclaims beneficial ownership of such 5,059,912 shares. D. E. Shaw & Co., L.P.: 5.1% David E. Shaw: 5.1% D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 5,000,212 shares David E. Shaw: 5,000,212 shares D. E. Shaw & Co., L.P.: 0 shares David E. Shaw: 0 shares D. E. Shaw & Co., L.P.: 5,059,912 shares David E. Shaw: 5,059,912 shares Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 2: Joint Filing Agreement, by and among the Reporting Persons, dated July 25, 2025. D. E. Shaw & Co., L.P. /s/ Daniel R. Marcus 07/25/2025 David E. Shaw /s/ Daniel R. Marcus 07/25/2025 This Schedule 13G amendment is being filed solely to include the Joint Filing Agreement, by and among the Reporting Persons, dated July 25, 2025 (Exhibit 2), which was omitted from the initial filing due to a technical issue encountered by our third-party filing service. Exhibit 1: Power of Attorney, granted by David E. Shaw relating to D. E. Shaw & Co., Inc., in favor of the signatories hereto, among others, dated August 1, 2024.