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    <submissionType>13F-NT</submissionType>
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      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
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      <filer>
        <credentials>
          <cik>0001009268</cik>
          <ccc>XXXXXXXX</ccc>
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      <periodOfReport>12-31-2019</periodOfReport>
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      <reportCalendarOrQuarter>12-31-2019</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>D. E. SHAW &amp; CO, L.P.</name>
        <address>
          <ns1:street1>1166 Avenue Of The Americas</ns1:street1>
          <ns1:street2>Ninth Floor</ns1:street2>
          <ns1:city>New York</ns1:city>
          <ns1:stateOrCountry>NY</ns1:stateOrCountry>
          <ns1:zipCode>10036</ns1:zipCode>
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      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-05394</form13FFileNumber>
      <otherManagersInfo>
        <otherManager>
          <cik>0001009207</cik>
          <form13FFileNumber>028-05396</form13FFileNumber>
          <name>D. E. Shaw &amp; Co., Inc.</name>
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      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>D. E. Shaw &amp; Co., Inc. may be deemed an institutional investment manager in its capacity as the general partner of D. E. Shaw &amp; Co., L.P., which in turn is the managing member of certain other affiliated institutional investment managers. D. E. Shaw &amp; Co., Inc. does not exercise investment or voting discretion, and therefore disclaims such discretion, with respect to Section 13(f) securities. D. E. Shaw &amp; Co., L.P. may be deemed to exercise investment or voting discretion for affiliated institutional investment managers. D. E. Shaw &amp; Co., L.P. does not exercise investment or voting discretion, and therefore disclaims such discretion, with respect to Section 13(f) securities over which such affiliated institutional investment managers exercise investment or voting discretion.</additionalInformation>
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    <signatureBlock>
      <name>Nathan Thomas</name>
      <title>Chief Compliance Officer</title>
      <phone>212-478-0000</phone>
      <signature>/s/ Nathan Thomas</signature>
      <city>New York</city>
      <stateOrCountry>NY</stateOrCountry>
      <signatureDate>02-14-2020</signatureDate>
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