AAC HLDGS INC COM 000307108 21284 1853998 SH DFND 01 1853998 0 0 ACADIA HEALTHCARE COMPANY IN COM 00404A109 29033 741016 SH DFND 01 741016 0 0 ACCELERON PHARMA INC COM 00434H108 24047 615000 SH DFND 01 615000 0 0 ACLARIS THERAPEUTICS INC COM 00461U105 48105 2745705 SH DFND 01 2745705 0 0 ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2448 422000 SH DFND 01 422000 0 0 AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 13186 16600000 PRN DFND 01 16600000 0 0 AERIE PHARMACEUTICALS INC COM 00771V108 26260 484055 SH DFND 01 484055 0 0 AETNA INC NEW COM 00817Y108 27885 165000 SH DFND 01 165000 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 29931 366000 SH DFND 01 366000 0 0 AIMMUNE THERAPEUTICS INC COM 00900T107 22606 710210 SH DFND 01 710210 0 0 ALBIREO PHARMA INC COM 01345P106 3908 120000 SH DFND 01 120000 0 0 ALIMERA SCIENCES INC COM 016259103 6235 6052935 SH DFND 01 6052935 0 0 ALLSCRIPTS HEALTHCARE SOLUTN NOTE 1.250% 7/0 01988PAD0 9708 9671000 PRN DFND 01 9671000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 17389 146000 SH DFND 01 146000 0 0 ALPINE IMMUNE SCIENCES INC COM 02083G100 7305 913100 SH DFND 01 913100 0 0 ANAPTYSBIO INC COM 032724106 82675 794338 SH DFND 01 794338 0 0 ANTHEM INC COM 036752103 41963 191000 SH DFND 01 191000 0 0 ARALEZ PHARMACEUTICALS INC COM 03852X100 2467 1644583 SH DFND 01 1644583 0 0 ARDELYX INC COM 039697107 13144 2602733 SH DFND 01 2602733 0 0 ARENA PHARMACEUTICALS INC COM NEW 040047607 27539 697194 SH DFND 01 697194 0 0 ARGENX SE SPONSORED ADR 04016X101 25734 319920 SH DFND 01 319920 0 0 ARMO BIOSCIENCES INC COM 04225U104 7053 188525 SH DFND 01 188525 0 0 ASCENDIS PHARMA A S SPONSORED ADR 04351P101 31553 482467 SH DFND 01 482467 0 0 AUDENTES THERAPEUTICS INC COM 05070R104 41603 1384470 SH DFND 01 1384470 0 0 AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 27618 3788540 SH DFND 01 3788540 0 0 AVEXIS INC COM 05366U100 93402 755798 SH DFND 01 755798 0 0 BIOCRYST PHARMACEUTICALS COM 09058V103 35138 7366460 SH DFND 01 7366460 0 0 BIOHAVEN PHARMACTL HLDG CO L COM G11196105 22385 869000 SH DFND 01 869000 0 0 BIOSCRIP INC COM 09069N108 7685 3124000 SH DFND 01 3124000 0 0 BLUEBIRD BIO INC COM 09609G100 7001 41000 SH DFND 01 41000 0 0 BLUEPRINT MEDICINES CORP COM 09627Y109 34750 378950 SH DFND 01 378950 0 0 CATALYST BIOSCIENCES INC COM NEW 14888D208 21430 830605 SH DFND 01 830605 0 0 CENTENE CORP DEL COM 15135B101 62840 588000 SH DFND 01 588000 0 0 CVS HEALTH CORP COM 126650100 34216 550000 SH DFND 01 550000 0 0 CVS HEALTH CORP COM 126650100 35261 566800 SH Call DFND 01 566800 0 0 CYMABAY THERAPEUTICS INC COM 23257D103 15759 1213181 SH DFND 01 1213181 0 0 CYTOMX THERAPEUTICS INC COM 23284F105 21432 753322 SH DFND 01 753322 0 0 DAVITA INC COM 23918K108 32075 486427 SH DFND 01 486427 0 0 DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 66903 2900000 SH DFND 01 2900000 0 0 DEPOMED INC NOTE 2.500% 9/0 249908AA2 22006 27019000 PRN DFND 01 27019000 0 0 DEXCOM INC COM 252131107 48130 649000 SH DFND 01 649000 0 0 DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25125 2500000 SH DFND 01 2500000 0 0 EDITAS MEDICINE INC COM 28106W103 38416 1158841 SH DFND 01 1158841 0 0 EGALET CORP COM 28226B104 2041 3239237 SH DFND 01 3239237 0 0 EHEALTH INC COM 28238P109 14751 1030802 SH DFND 01 1030802 0 0 ENDOCYTE INC COM 29269A102 23884 2627540 SH DFND 01 2627540 0 0 ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 34899 40500000 PRN DFND 01 40500000 0 0 EPIZYME INC COM 29428V104 17057 960970 SH DFND 01 960970 0 0 EXACT SCIENCES CORP DBCV 1.000% 1/1 30063PAA3 11083 12500000 PRN DFND 01 12500000 0 0 EYENOVIA INC COM 30234E104 2745 300000 SH DFND 01 300000 0 0 FOAMIX PHARMACEUTICALS LTD SHS M46135105 3458 674002 SH DFND 01 674002 0 0 G1 THERAPEUTICS INC COM 3621LQ109 13820 373000 SH DFND 01 373000 0 0 GALAPAGOS NV SPON ADR 36315X101 12969 130000 SH DFND 01 130000 0 0 GLAUKOS CORP COM 377322102 50655 1643031 SH DFND 01 1643031 0 0 GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 31647 810000 SH DFND 01 810000 0 0 GW PHARMACEUTICALS PLC ADS 36197T103 25402 225452 SH DFND 01 225452 0 0 HOMOLOGY MEDICINES INC COM 438083107 97746 5227035 SH DFND 01 5227035 0 0 HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 91055 99100000 PRN DFND 01 99100000 0 0 HORIZON PHARMA PLC SHS G4617B105 93860 6609894 SH DFND 01 6609894 0 0 IGI LABORATORIES INC NOTE 3.750%12/1 449575AB5 10750 11600000 PRN DFND 01 11600000 0 0 IMMUNOMEDICS INC COM 452907108 13594 930448 SH DFND 01 930448 0 0 INFLARX NV COM N44821101 2552 88500 SH DFND 01 88500 0 0 INSULET CORP COM 45784P101 14822 171000 SH DFND 01 171000 0 0 INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 28596 36000000 PRN DFND 01 36000000 0 0 INTERSECT ENT INC COM 46071F103 32717 832500 SH DFND 01 832500 0 0 INVITAE CORP COM 46185L103 8919 1901788 SH DFND 01 1901788 0 0 INVUITY INC COM NEW 46187J205 8997 2336889 SH DFND 01 2336889 0 0 ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 45283 45700000 PRN DFND 01 45700000 0 0 K2M GROUP HLDGS INC NOTE 4.125% 8/1 48273JAB3 23444 20000000 PRN DFND 01 20000000 0 0 KEMPHARM INC NOTE 5.500% 2/0 488445AB3 57250 75000000 PRN DFND 01 75000000 0 0 LANNET INC COM 516012101 43994 2741077 SH DFND 01 2741077 0 0 MALLINCKRODT PUB LTD CO SHS G5785G107 124838 8621383 SH DFND 01 8621383 0 0 MANNKIND CORP COM NEW 56400P706 3380 1482601 SH DFND 01 1482601 0 0 MCKESSON CORP COM 58155Q103 21131 150000 SH DFND 01 150000 0 0 MELINTA THERAPEUTICS INC COM 58549G100 23146 3127846 SH DFND 01 3127846 0 0 MENLO THERAPEUTICS INC COM 586858102 16037 426749 SH DFND 01 426749 0 0 MIRATI THERAPEUTICS INC COM 60468T105 6048 197000 SH DFND 01 197000 0 0 MOLINA HEALTHCARE INC COM 60855R100 13638 168000 SH DFND 01 168000 0 0 MYLAN N V SHS EURO N59465109 104906 2548111 SH DFND 01 2548111 0 0 MYOKARDIA INC COM 62857M105 52152 1068680 SH DFND 01 1068680 0 0 NATERA INC COM 632307104 29479 3180000 SH DFND 01 3180000 0 0 NEOS THERAPEUTICS INC COM 64052L106 7179 864906 SH DFND 01 864906 0 0 NEVRO CORP NOTE 1.750% 6/0 64157FAA1 31273 27600000 PRN DFND 01 27600000 0 0 NUVASIVE INC NOTE 2.250% 3/1 670704AG0 11001 10000000 PRN DFND 01 10000000 0 0 OBALON THERAPEUTICS INC COM 67424L100 1531 446284 SH DFND 01 446284 0 0 ORTHOPEDIATRICS CORP COM 68752L100 877 58247 SH DFND 01 58247 0 0 OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 17978 1444000 SH DFND 01 1444000 0 0 PFENEX INC COM 717071104 9957 1659501 SH DFND 01 1659501 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 16330 500000 SH Call DFND 01 500000 0 0 PORTOLA PHARMACEUTICALS INC COM 737010108 16330 500000 SH Put DFND 01 500000 0 0 PROTEON THERAPEUTICS INC COM 74371L109 3062 1224899 SH DFND 01 1224899 0 0 RA PHARMACEUTICALS INC COM 74933V108 2032 382700 SH DFND 01 382700 0 0 RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 21134 21000000 PRN DFND 01 21000000 0 0 REATA PHARMACEUTICALS INC CL A 75615P103 7999 390000 SH DFND 01 390000 0 0 RECRO PHARMA INC COM 75629F109 11120 1010000 SH DFND 01 1010000 0 0 REGENXBIO INC COM 75901B107 7651 256300 SH DFND 01 256300 0 0 RHYTHM PHARMACEUTICALS INC COM 76243J105 11582 582010 SH DFND 01 582010 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 7500 400000 SH DFND 01 400000 0 0 SCYNEXIS INC COM 811292101 1367 1020000 SH DFND 01 1020000 0 0 SELECT MED HLDGS CORP COM 81619Q105 32051 1858000 SH DFND 01 1858000 0 0 SIENTRA INC COM 82621J105 1063 110000 SH DFND 01 110000 0 0 SIERRA ONCOLOGY INC COM 82640U107 3653 1764889 SH DFND 01 1764889 0 0 STEADYMED LTD SHS M84920103 4611 1418787 SH DFND 01 1418787 0 0 SYNLOGIC INC COM 87166L100 12805 1365143 SH DFND 01 1365143 0 0 SYROS PHARMACEUTICALS INC COM 87184Q107 16471 1268945 SH DFND 01 1268945 0 0 TACTILE SYS TECHNOLOGY INC COM 87357P100 2894 91020 SH DFND 01 91020 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 1577 318000 SH DFND 01 318000 0 0 TELIGENT INC NEW COM 87960W104 1609 479000 SH DFND 01 479000 0 0 TESARO INC COM 881569107 2451 42893 SH DFND 01 42893 0 0 TRINITY BIOTECH INVT LTD NOTE 4.000% 4/0 89643QAB4 38550 48000000 PRN DFND 01 48000000 0 0 UNIVERSAL HLTH SVCS INC CL B 913903100 31023 262000 SH DFND 01 262000 0 0 VOYAGER THERAPEUTICS INC COM 92915B106 2211 117647 SH DFND 01 117647 0 0 WALGREENS BOOTS ALLIANCE INC COM 931427108 23307 356000 SH DFND 01 356000 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 10754 268174 SH DFND 01 268174 0 0 WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 12579 634000 SH DFND 01 634000 0 0 WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 35763 31500000 PRN DFND 01 31500000 0 0 XENCOR INC COM 98401F105 26456 882462 SH DFND 01 882462 0 0 ZIMMER BIOMET HLDGS INC COM 98956P102 13194 121000 SH DFND 01 121000 0 0