ACCELERON PHARMA INC COM 00434H108 72618 1369625 SH DFND 1 1369625 0 0 ADAPTHEALTH CORP COM CL A 00653Q102 188855 17199888 SH DFND 1 17199888 0 0 ADDUS HOMECARE CORP COM 006739106 19241 197915 SH DFND 1 197915 0 0 ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2435 211343 SH DFND 1 211343 0 0 AERIE PHARMACEUTICALS INC COM 00771V108 42835 1772255 SH DFND 1 1772255 0 0 AERIE PHARMACEUTICALS INC COM 00771V108 2509 103800 SH Put DFND 1 103800 0 0 ALECTOR INC COM 014442107 35783 2076812 SH DFND 1 2076812 0 0 ALPINE IMMUNE SCIENCES INC COM 02083G100 956 248992 SH DFND 1 248992 0 0 ARDELYX INC COM 039697107 52567 7004253 SH DFND 1 7004253 0 0 ARGENX SE SPONSORED ADR 04016X101 29536 184000 SH DFND 1 184000 0 0 ARVINAS INC COM 04335A105 44716 1088234 SH DFND 1 1088234 0 0 ATRICURE INC COM 04963C209 9518 292777 SH DFND 1 292777 0 0 AUDENTES THERAPEUTICS INC COM 05070R104 29555 493901 SH DFND 1 493901 0 0 AVROBIO INC COM 05455M100 23451 1164970 SH DFND 1 1164970 0 0 AXONICS MODULATION TECH INC COM 05465P101 23219 837945 SH DFND 1 837945 0 0 BIOCRYST PHARMACEUTICALS COM 09058V103 21994 6375143 SH DFND 1 6375143 0 0 BLUEPRINT MEDICINES CORP COM 09627Y109 45255 564914 SH DFND 1 564914 0 0 BROOKDALE SR LIVING INC COM 112463104 52514 7223419 SH DFND 1 7223419 0 0 CABALETTA BIO INC COM 12674W109 22750 1628504 SH DFND 1 1628504 0 0 CENTENE CORP DEL COM 15135B101 69685 1108400 SH DFND 1 1108400 0 0 CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 42905 49064000 PRN DFND 1 49064000 0 0 CONSTELLATION PHARMCETICLS I COM 210373106 25911 550000 SH DFND 1 550000 0 0 DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 50889 4756000 SH DFND 1 4756000 0 0 DECIPHERA PHARMACEUTICALS IN COM 24344T101 19170 308000 SH DFND 1 308000 0 0 DEXCOM INC NOTE 0.750%12/0 252131AH0 50441 34000000 SH DFND 1 34000000 0 0 EDITAS MEDICINE INC COM 28106W103 34313 1158841 SH DFND 1 1158841 0 0 EHEALTH INC COM 28238P109 19600 204000 SH DFND 1 204000 0 0 FATE THERAPEUTICS INC COM 31189P102 39191 2002605 SH DFND 1 2002605 0 0 FORTY SEVEN INC COM 34983P104 17598 447000 SH DFND 1 447000 0 0 FREQUENCY THERAPEUTICS INC COM 35803L108 24869 1418665 SH DFND 1 1418665 0 0 GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 19952 251000 SH DFND 1 251000 0 0 HOMOLOGY MEDICINES INC COM 438083107 108585 5245638 SH DFND 1 5245638 0 0 HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 191529 144832000 PRN DFND 1 144832000 0 0 HORIZON THERAPEUTICS PUB LTD SHS G46188101 171672 4742311 SH DFND 1 4742311 0 0 HUMANA INC COM 444859102 30055 82000 SH DFND 1 82000 0 0 IMMUNOMEDICS INC COM 452907108 36451 1722618 SH DFND 1 1722618 0 0 INOGEN INC COM 45780L104 2529 37016 SH DFND 1 37016 0 0 INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 58256 57791000 PRN DFND 1 57791000 0 0 INTERCEPT PHARMACEUTICALS IN NOTE 2.000% 5/1 45845PAB4 4632 3500000 SH DFND 1 3500000 0 0 INTERSECT ENT INC COM 46071F103 69646 2797033 SH DFND 1 2797033 0 0 ITAMAR MED LTD SPONSORED ADS 465437101 4043 314136 SH DFND 1 314136 0 0 IVERIC BIO INC COM 46583P102 8580 1000000 SH DFND 1 1000000 0 0 KEMPHARM INC COM 488445107 196 517692 SH DFND 1 517692 0 0 KODIAK SCIENCES INC COM 50015M109 14390 200000 SH DFND 1 200000 0 0 MALLINCKRODT PUB LTD CO SHS G5785G107 14053 4026750 SH DFND 1 4026750 0 0 MIRATI THERAPEUTICS INC COM 60468T105 22422 174000 SH DFND 1 174000 0 0 MIRUM PHARMACEUTICALS INC COM 604749101 84567 3448912 SH DFND 1 3448912 0 0 MOLINA HEALTHCARE INC COM 60855R100 20141 148433 SH DFND 1 148433 0 0 MYLAN N V SHS EURO N59465109 163850 8151754 SH DFND 1 8151754 0 0 MYOKARDIA INC COM 62857M105 57506 789000 SH DFND 1 789000 0 0 NEOS THERAPEUTICS INC COM 64052L106 485 320993 SH DFND 1 320993 0 0 NEURONETICS INC COM 64131A105 4827 1075000 SH DFND 1 1075000 0 0 NEVRO CORP NOTE 1.750% 6/0 64157FAA1 154250 115776000 PRN DFND 1 115776000 0 0 ORCHARD THERAPEUTICS PLC ADS 68570P101 121856 8862247 SH DFND 1 8862247 0 0 ORTHOPEDIATRICS CORP COM 68752L100 10573 225000 SH DFND 1 225000 0 0 PROTEON THERAPEUTICS INC COM 74371L109 832 2029000 SH DFND 1 2029000 0 0 PTC THERAPEUTICS INC NOTE 3.000% 8/1 69366JAB7 28400 24877000 PRN DFND 1 24877000 0 0 PUMA BIOTECHNOLOGY INC COM 74587V107 3469 396472 SH DFND 1 396472 0 0 RA PHARMACEUTICALS INC COM 74933V108 71320 1519718 SH DFND 1 1519718 0 0 REATA PHARMACEUTICALS INC CL A 75615P103 20443 100000 SH DFND 1 100000 0 0 REVANCE THERAPEUTICS INC COM 761330109 14607 900000 SH DFND 1 900000 0 0 RHYTHM PHARMACEUTICALS INC COM 76243J105 98482 4289291 SH DFND 1 4289291 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 49263 2164471 SH DFND 1 2164471 0 0 SAREPTA THERAPEUTICS INC COM 803607100 27098 210000 SH DFND 1 210000 0 0 SELECT MED HLDGS CORP COM 81619Q105 18513 793200 SH DFND 1 793200 0 0 SHOCKWAVE MED INC COM 82489T104 3074 70000 SH DFND 1 70000 0 0 SIENTRA INC COM 82621J105 37795 4227680 SH DFND 1 4227680 0 0 SILK ROAD MEDICAL INC COM 82710M100 51665 1279480 SH DFND 1 1279480 0 0 SPRINGWORKS THERAPEUTICS INC COM 85205L107 30339 788243 SH DFND 1 788243 0 0 SYROS PHARMACEUTICALS INC COM 87184Q107 8768 1268946 SH DFND 1 1268946 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 81150 1361345 SH DFND 1 1361345 0 0 THERAPEUTICSMD INC COM STK COM 88338N107 5445 2250000 SH DFND 1 2250000 0 0 TURNING POINT THERAPEUTICS I COM 90041T108 22798 366000 SH DFND 1 366000 0 0 VERICEL CORP COM 92346J108 47808 2747563 SH DFND 1 2747563 0 0 X4 PHARMACEUTICALS INC COM 98420X103 4809 449437 SH DFND 1 449437 0 0 XERIS PHARMACEUTICALS INC COM 98422L107 18212 2583291 SH DFND 1 2583291 0 0