<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001588386</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001009001</issuerCik>
      <issuerName>Cameco Corporation</issuerName>
      <secFileNumber>001-14228</secFileNumber>
      <issuerAddress>
        <com:street1>2121 11th Street West</com:street1>
        <com:city>Saskatoon</com:city>
        <com:stateOrCountry>A9</com:stateOrCountry>
        <com:zipCode>S7M 1J3</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>3063855286</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gitzel Timothy S.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Shares</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Solium Financial Inc.</name>
        <address>
          <com:street1>1500, 800 - 6th Avenue SW</com:street1>
          <com:city>Calgary</com:city>
          <com:stateOrCountry>A0</com:stateOrCountry>
          <com:zipCode>T2P 3G3</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>50000</noOfUnitsSold>
      <aggregateMarketValue>4499500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>435407158</noOfUnitsOutstanding>
      <approxSaleDate>12/19/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Shares</securitiesClassTitle>
      <acquiredDate>12/19/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Cameco Corporation</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
      <paymentDate>12/19/2025</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>12/19/2025</noticeDate>
      <signature>Timothy S. Gitzel</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
