Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Deferred tax assets:
Net operating loss carryforward	$ 77,510	$ 61,774
Tax credits	34,332	33,577
Stock based compensation	12,257	17,454
Contingent consideration	12,730	11,975
Employee compensation	1,513	2,638
Rebate and returns reserve	2,290	3,339
Capitalized R&D	10,696	11,564
Other	7,656	9,651
Total deferred tax assets	275,710	273,023
Valuation allowance	(193,253)	(186,491)	$ (177,572)
Total deferred tax assets net of valuation allowance	82,457	86,532
Capital loss carryforward	116,717	106,371
Derivative liability	9	296
Asset impairment		14,384
Deferred tax liabilities:
Intangible assets	(83,930)	(88,547)
Convertible debt	(12,842)	(16,227)
Depreciation	400	(803)
Other	(15)	(72)
Total deferred tax liabilities	(96,387)	(105,649)
Net deferred tax liability	$ (13,930)	$ (19,117)