Income Taxes - Schedule of Reconciliation of the Statutory U.S. Federal Income Tax Rate to the Entity's Effective Income Tax Rate (Details)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Reconciliation of statutory federal income tax rate to effective income tax rate
U.S. federal statutory tax rate	21.00%	21.00%
State and local income taxes	0.40%	(3.00%)
Stock option compensation	(0.10%)	0.30%
Stock option shortfall	(5.00%)	(5.80%)
Research and development and orphan drug credits		(0.40%)
Uncertain tax positions	0.50%	0.10%
Other nondeductible and permanent differences	(2.60%)	(2.50%)
Valuation allowance, net of foreign tax rate differential	(9.50%)	(7.60%)
Tax effect of NOL carryback - CARES Act		5.40%
Effective income tax rate	4.70%	7.50%