Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax [Line Items]
Change Of Control Ownership Percentage Threshold	50.00%
Change Of Control Ownership Measurement Period	3 years
Deferred tax assets, valuation allowance	$ 193,253	$ 186,491	$ 177,572
US federal corporate tax rate	21.00%	21.00%
Tax Deduction	0.00%
Minimum
Recent Accounting Pronouncements
Expiration term for statute of limitations	3 years
Maximum
Recent Accounting Pronouncements
Expiration term for statute of limitations	5 years
Federal
Income Tax [Line Items]
Operating loss carryforwards	$ 112,400
Percentage of taxable income will be utilized in any year	80.00%
Operating loss carryforwards additional	$ 471,000
Biotie U S
Income Tax [Line Items]
Operating loss carryforwards	$ 121,600
Operating loss, expected expiration beginning year	2026
State
Income Tax [Line Items]
Operating loss carryforwards	$ 304,800	$ 267,000
Operating loss, expected expiration beginning year	2027
Outside U.S.
Income Tax [Line Items]
Operating loss carryforwards	$ 48,200
Operating loss, expected expiration beginning year	2022
Research [Member]
Income Tax [Line Items]
Tax credit carry-forwards	$ 35,300	$ 35,300
Tax credit carry-forward, expiration beginning year	2022
Capital Loss Carryforward | State
Income Tax [Line Items]
Deferred tax assets, valuation allowance	$ 6,800