Debt - Additional Information (Details) $ / shares in Units, € in Millions			6 Months Ended	9 Months Ended	12 Months Ended
	Sep. 17, 2020 USD ($) shares	Dec. 24, 2019 USD ($) TradingDay	Dec. 31, 2021 USD ($) $ / shares shares	Sep. 30, 2020 USD ($)	Dec. 31, 2021 USD ($) Loan $ / shares shares	Dec. 31, 2020 USD ($) shares	Dec. 31, 2019 USD ($) shares	Apr. 18, 2016 USD ($)	Apr. 18, 2016 EUR (€)	Jun. 17, 2014 USD ($)
Debt Instrument [Line Items]
Cash payment made for exchange of notes		$ 200
Aggregate payment on debt exchange		55,200,000			$ 69,000,000
Debt instrument, principal amount outstanding			$ 207,000,000		207,000,000
Reverse stock split, description						1-for-6 reverse stock split
Gain on debt extinguishment					55,100,000
Adjusted equity component of convertible notes exchange					38,400,000
Fair value of derivative liability			$ 37,000		$ 37,000
Common stock, Authorized shares | shares	61,666,666		61,666,666		61,666,666	61,666,666	13,333,333
Derivative liability reclassified to equity	$ 18,300,000
Income tax effects on equity transactions				$ 4,400,000	$ 4,400,000
Interest expense					30,035,000	$ 30,574,000
Debt Issuance Costs, Gross			$ 5,700,000		5,700,000
Reclassification of derivative liability to equity, net of tax						14,053,000
Cash			5,300,000		5,300,000
Letters of Credit
Debt Instrument [Line Items]
Restricted Cash and Cash Equivalents			300,000		300,000
Research and development loans
Debt Instrument [Line Items]
Principal			0		$ 0
Fair value of debt								$ 2,900,000	€ 2.6
Finland's Ministry of Finance | Research and development loans
Debt Instrument [Line Items]
Loan repayment ending period					2021-01
Non-Convertible Capital Loan
Debt Instrument [Line Items]
Principal			$ 27,600,000		$ 27,600,000
Fair value of debt								$ 20,500,000	€ 18.2
Number of loans | Loan					14
Non-Convertible Capital Loan | Finland's Ministry of Finance
Debt Instrument [Line Items]
Basis Spread to be reduced (as a percent)					1.00%
Minimum | Non-Convertible Capital Loan
Debt Instrument [Line Items]
Maturity date					8 years
Minimum | Non-Convertible Capital Loan | Finland's Ministry of Finance
Debt Instrument [Line Items]
Effective interest rate on liability component (as a percent)			3.00%		3.00%
Minimum | Non-Convertible Capital Loan | Finland's Ministry of Finance | Biotie U S
Debt Instrument [Line Items]
Cash			$ 14,800,000		$ 14,800,000
Maximum | Non-Convertible Capital Loan
Debt Instrument [Line Items]
Maturity date					10 years
Convertible Senior Notes due 2021
Debt Instrument [Line Items]
Principal amount of debt exchanged		$ 276,000,000.0
Interest rate (as a percent)		1.75%
Principal amount denomination for debt conversion		$ 1,000
Principal										$ 345,000,000
Debt instrument, principal amount outstanding			69,000,000.0		$ 69,000,000.0	69,000,000	$ 69,000,000.0
Interest expense					1,457,000	3,377,000
Debt Issuance Costs, Gross			$ 7,500,000		7,500,000
Reclassification of derivative liability to equity, net of tax					1,300,000
Debt issuance costs allocated to liability component					6,200,000
Debt issuance cost associated with exchange, written off					$ 1,200,000
Convertible Senior Secured Notes due 2024
Debt Instrument [Line Items]
Interest rate (as a percent)		6.00%					6.00%
Principal amount of debt issued for exchange		$ 750
Principal		$ 207,000,000.0
Debt instrument, principal amount outstanding						$ 207,000,000
Notes maturity date		Dec. 01, 2024
Interest payment in shares, percentage of daily volume-weighted average price		95.00%
Notes frequency of periodic payment						semi-annually in arrears
Interest in shares of common stock, threshold trading days | TradingDay		10
Initial conversion rate of common stock					47.6190
Initial conversion price of convertible notes into common stock (in dollars per share) | $ / shares			$ 21.00		$ 21.00
Principal amount of Notes or an integral multiple thereof in which holder may repurchase the Notes			$ 1,000		$ 1,000
Reverse stock split, description					1-for-6
Debt instrument conversion threshold stock price percentage		130.00%
Debt repurchase price percentage on principal amount		100.00%
Debt default, nonpayment of interest, period		30 days
Debt default, failure to convert notes, period		5 days
Debt default, non-compliance with covenants, period		60 days
Fair value of derivative liability		$ 59,400,000				$ 1,193,000
Debt discount		75,100,000
Interest expense		$ 25,800,000			$ 25,826,000	$ 23,648,000
Effective interest rate on liability component (as a percent)		18.13%
Debt fair value amount		$ 142,600,000
Convertible Senior Secured Notes due 2024 | Minimum
Debt Instrument [Line Items]
Debt default, non-payment of outstanding principal		30,000,000.0
Debt default, failure to pay final judgements		$ 30,000,000.0
Debt default, percentage of principal outstanding required for immediate payment		25.00%
Convertible Senior Secured Notes due 2024 | Interest Payable
Debt Instrument [Line Items]
Interest payable to holders | shares					2,049,048
Stock based interest payment			$ 6,200,000		$ 12,400,000