Common Stock Options and Restricted Stock - Schedule of Stock Options Activity (Details) shares in Thousands	12 Months Ended
	Dec. 31, 2021 $ / shares shares
Stock Option Activity
Beginning balance (in shares) | shares	1,331
Granted (in shares) | shares	336
Forfeited and expired (in shares) | shares	(481)
Ending balance (in shares) | shares	1,186
Vested and expected to vest at the end of the period | shares	1,172
Vested and exercisable at the end of the period | shares	872
Weighted Average Exercise Price
Balance at the beginning of the period (in dollars per share) | $ / shares	$ 127.13
Granted (in dollars per share) | $ / shares	3.72
Forfeited and expired (in dollars per share) | $ / shares	121.78
Balance at the end of the period (in dollars per share) | $ / shares	94.38
Vested and expected to vest at the end of the period (in dollars per share) | $ / shares	95.42
Vested and exercisable at the end of the period (in dollars per share) | $ / shares	$ 125.89
Weighted Average Remaining Contractual Term
Balance at the end of the period	5 years 6 months
Vested and expected to vest at the end of the period	5 years 6 months
Vested and exercisable at the end of the period	4 years