Leases - Additional Information (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2018 ft²	Oct. 31, 2016 USD ($) ft²	Dec. 31, 2014 ft²	Jun. 30, 2011 ft²
Operating Lease Information
ROU assets	$ 6,751	$ 18,481
Lease liabilities	$ 12,272
Operating lease description	Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. The Company’s leases have remaining lease terms of 0.5 years to 5 years.   The Company has exercised the option to terminate the Ardsley lease with a termination date of June 22, 2022.
Operating lease renewal option	true
Operating lease termination option	true
Operating lease termination date	Jun. 22, 2022
Operating lease weighted-average remaining lease term	2 years 4 months 24 days
Operating lease weighted-average discount rate	7.13%
Ardsley, New York | Office and Laboratory Space
Operating Lease Information
Operating lease renewal option	true
Operating lease termination option	true
Lease term						15 years
Area of leased property | ft²						138,000
Additional Lease Option Rights Exercised (In Square Feet) | ft²					25,405
Termination Option Date	--06-22
Base Rent	$ 5,000
Termination Fee	4,700
Chelsea, Massachusetts | Manufacturing Facility
Operating Lease Information
Area of leased property | ft²			95,000
Contribution Of Fund Agreed	$ 1,500
Waltham, MA | Office and Laboratory Space
Operating Lease Information
Lease term				10 years
Area of leased property | ft²				26,000
Base Rent				$ 1,100
Minimum
Operating Lease Information
Operating lease remaining lease term	6 months
Maximum
Operating Lease Information
Operating lease remaining lease term	5 years