Summary of Significant Accounting Policies - Additional Information (Details)		1 Months Ended		3 Months Ended	12 Months Ended
	Oct. 01, 2017 USD ($)	Nov. 30, 2021 USD ($)	Mar. 31, 2020 USD ($)	Mar. 31, 2020 USD ($)	Dec. 31, 2021 USD ($) Customer Segment shares	Dec. 31, 2020 USD ($) Segment shares	Sep. 30, 2020 shares	Sep. 17, 2020 shares	Dec. 31, 2019 shares
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Reverse stock split, description						1-for-6 reverse stock split
Stockholders' equity note, stock split, conversion ratio						0.167
Common stock, Authorized shares | shares					61,666,666	61,666,666		61,666,666	13,333,333
Restricted Cash
Investments					$ 0	$ 0
Other Comprehensive Income (Loss)
Foreign currency translation adjustment, Tax					0	0
Foreign currency translation adjustment					1,786,000	(1,607,000)
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Credit received as reduction to payroll tax expense					4,200,000
Contract Liabilities					5,900,000	0
Contract Assets					$ 0	0
Allowance for Cash Discounts
Time period needed typically to settle cash discounts					34 days
Allowance for cash discounts					$ 2,000,000.0	1,000,000.0
Reserve for allowance for cash discounts					800,000	600,000
Allowance for Doubtful Accounts
Allowance for doubtful accounts, provisions					200,000	0
Allowance for doubtful accounts, write-offs					200,000	0
Allowance related to chargebacks					1,000,000.0	2,300,000
Payment related to chargebacks					$ 1,500,000	2,000,000.0
Reserve for chargebacks allowance						$ 500,000
Segment and Geographic Information
Number of operating segments | Segment					1	1
Number of reportable operating segments | Segment					1	1
Cash and cash equivalents					$ 45,600,000	$ 71,400,000
Net loss					(103,954,000)	$ (99,594,000)
Cash And Cash Equivalents Not Obligated To Pay					$ 5,300
Product revenue
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Number of customers | Customer					4
Accounts receivable
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Number of customers | Customer					4
Esteve Germany [Member]
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Upfront Payment Received		$ 5,900,000			$ 5,900
Deferred Revenue					0
Deferred Revenue Related To Unsatisfied Performance Obligations					5,900
Upfront Payment Recognized		$ 5,900,000			$ 5,900
Royalty Agreement
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Non cash royalty payment received	$ 40,000,000
Estimated effective annual interest rate					15.00%
IPR&D
Property and Equipment
Impairment Charges				$ 4,100,000
Fair value of the IPR&D asset			$ 0	0
Carrying value of the asset			$ 4,100,000	$ 4,100,000
Minimum
Property and Equipment
Estimated useful lives					1 year
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Product revenue payment term					30 days
Minimum | Supply agreement | Alkermes License Agreement
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Compensatory Payments Purchase Requirements Threshold Percentage					75.00%
Maximum
Property and Equipment
Estimated useful lives					7 years
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Product revenue payment term					35 days
Maximum | Supply agreement | Alkermes License Agreement
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Compensatory Payments Purchase Requirements Threshold Percentage					100.00%
Maximum | Supply agreement | Patheon Inc Second Manufacturing agreement
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Compensatory Payments Purchase Requirements Threshold Percentage					25.00%
UNITED STATES | Customers | Product revenue
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Concentration risk, percentage					91.00%	90.00%
UNITED STATES | Customers | Accounts receivable
Non-Cash Interest Expense on Liability Related to Sale of Future Royalties
Concentration risk, percentage					92.00%	84.00%
Cost of Goods Sold | Chelsea, Massachusetts
Other Comprehensive Income (Loss)
Idle capacity charge					$ 100,000	$ 6,300,000
Research And Development [Member]
Property and Equipment
Impairment Charges						$ 4,100
Letters of Credit
Restricted Cash
Restricted Cash and Cash Equivalents					300,000
Restricted Cash - Non Current
Restricted Cash
Escrow account for interest payments					$ 5,900,000
Previously Reported
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Common stock, Authorized shares | shares							370,000,000		80,000,000