Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Total net revenues	$ 129,071	$ 152,967
Costs and expenses:
Cost of sales	40,787	33,513
Research and development	10,420	23,012
Selling, general and administrative	124,399	152,576
Intangible asset impairments		4,131
Loss on assets held for sale		57,896
Amortization of intangible assets	30,764	30,763
Changes in fair value of derivative liability	(1,156)	(39,959)
Changes in fair value of acquired contingent consideration	2,895	(30,889)
Total operating expenses	208,109	231,043
Operating loss	(79,038)	(78,076)
Other income (expense), net:
Interest and amortization of debt discount expense	(30,035)	(30,574)
Interest income	5	816
Other income (expense)	(6)	167
Total other income (expense), net	(30,036)	(29,591)
Loss before taxes	(109,074)	(107,667)
Benefit from income taxes	5,120	8,073
Net loss	$ (103,954)	$ (99,594)
Net loss per share—basic	$ (9.79)	$ (12.32)
Net loss per share—diluted	$ (9.79)	$ (12.32)
Weighted average common shares outstanding used in computing net loss per share—basic	10,621	8,084
Weighted average common shares outstanding used in computing net loss per share—diluted	10,621	8,084
Net Product Revenues
Revenues:
Total net revenues	$ 114,189	$ 124,831
Milestone Revenues
Revenues:
Total net revenues		15,000
Royalty Revenues
Revenues:
Total net revenues	$ 14,882	$ 13,136