Common Stock Options and Restricted Stock (Tables)

12 Months Ended

Dec. 31, 2021

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Schedule of Weighted Average Assumptions Using the Black-Scholes Option Pricing Model

The fair value of each option granted is estimated on the date of grant using the Black‑Scholes option‑pricing model with the following weighted average assumptions:

	Year ended December 31,
	2021			2020
Employees and directors:
Estimated volatility%		84.26	%		80.28	%
Expected life in years		6.25			6.31
Risk free interest rate%		1.36	%		0.69	%
Dividend yield		—			—

Schedule of Share-based Compensation Expense

The following table summarizes share-based compensation expense included within the Company’s consolidated statements of operations:

	Year ended December 31,
(In thousands)	2021		2020
Research and development	$	694	$	1,745
Selling, general and administrative		2,282		6,020
Cost of sales		19		335
Total	$	2,995	$	8,100

Schedule of Stock Option Activity

A summary of share‑based compensation activity for the year ended December 31, 2021 is presented below:

	Number of Shares (In thousands)			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term		Intrinsic Value (In thousands)
Balance at December 31, 2020		1,331		$	127.13
Granted		336			3.72
Forfeited and expired		(481	)		121.78
Exercised		—			—
Balance at December 31, 2021		1,186		$	94.38		5.5	$
Vested and expected to vest at December 31, 2021		1,172		$	95.42		5.5	$
Vested and exercisable at December 31, 2021		872		$	125.89		4.0		—

Schedule of Stock Options Activity, By Exercise Price Range

	Options Outstanding						Options Exercisable
Range of exercise price	Outstanding as of December 31, 2021 (In thousands)		Weighted- average remaining contractual life (In years)		Weighted- average exercise price		Exercisable as of December 31, 2021 (In thousands)		Weighted- average exercise price
$3.16 - $3.74		276		9.8	$	3.70		1	$	3.18
$3.75 - $14.46		284		7.1		11.98		257	$	12.77
$15.30 - $164.85		265		3.6		124.60		253	$	126.67
$165.30 - $214.44		277		2.5		197.68		277	$	197.70
$215.28 - $246.42		84		2.1		234.91		84	$	234.91
		1,186		5.5	$	94.38		872	$	125.89

Schedule of Restricted Stock Activity

Restricted Stock	Number of Shares (In thousands)
Nonvested at December 31, 2020		31
Granted		261
Vested		(104	)
Forfeited		(72	)
Nonvested at December 31, 2021		116